A closer look at the behaviour of milk lipids during digestion

Clulow, Andrew J.; Salim, Malinda; Hawley, Adrian

doi:10.1016/j.chemphyslip.2017.10.009

Cited by 53 publications

(98 citation statements)

References 27 publications

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“…As described in previous studies, the average volume-weighted mean diameter (D 4,3 ) of homogenised milk is around 0.56–0.63 μm (Gallier et al, 2013, Clulow et al, 2018). In contrast, the average particle size was greater after dispersion of the freeze-dried milk tablets (average 5.86 μm) and infant formula tablets (average 2.0 μm).…”

Section: Resultssupporting

confidence: 65%

Revisiting dispersible milk-drug tablets as a solid lipid formulation in the context of digestion

Bakar

Salim

Clulow

et al. 2019

International Journal of Pharmaceutics

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Section: Resultssupporting

confidence: 65%

Revisiting dispersible milk-drug tablets as a solid lipid formulation in the context of digestion

Bakar

Salim

Clulow

et al. 2019

International Journal of Pharmaceutics

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“…Lyotropic phases also act as a responsive delivery matrix manipulated by nature during food digestion. In model systems simulating human digestion, the action of enzymes and bile acids provide important functions that tune the lipid self‐assembly behavior including the formation of bicontinuous cubic structures. Enzymatic lipolysis of triglycerides in the gut produces diglycerides, monoglycerides, and fatty acids, which upon interaction with bile components leads to the appearance of a plethora of self‐assembled structures such as the L 2 phase, the inverse micellar cubic phase ( Fd 3 m ), the inverse hexagonal phase, the inverse bicontinuous cubic phase, and finally vesicles (resulting from the dispersion of a lamellar liquid crystalline phase) and physiological micelles having positive curvature corresponding to the so‐called L 1 phase.…”

Section: Lipidic Lyotropic Liquid Crystalline Phases In Naturementioning

confidence: 99%

“…For this reason, these nature‐derived materials are close relatives of their synthetic counterparts, with a similar length scale, composition, and self‐assembly scheme. It is interesting to notice that for the bicontinuous cubic structure (space group

P n \bar{3} m

), a lattice parameter of 21.7 nm was observed while in most synthetic dispersions of monoacylglycerol, it is in the range of 10 nm . It is very likely that the presence of the ionized oleic acid ensures repulsion between the layers and higher lattice parameter (vide infra).…”

Section: Lipidic Lyotropic Liquid Crystalline Phases In Naturementioning

confidence: 99%

“…Recently, in vitro digestion of milk has also been studied; similarly to the digestion of vegetable oils, a systematic transformation through a series of lipidic lyotropic liquid crystalline phases was observed . Persistent lamellar phases were also observed throughout the digestion process arising from the formation of salts composed of calcium and fatty acids, mainly the saturated fatty acids. The calcium soap formation in vivo is believed to lead to limited absorption of calcium and fatty acids for small infants or premature babies …”

Section: Lipidic Lyotropic Liquid Crystalline Phases In Naturementioning

confidence: 99%

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Nature‐Inspired Design and Application of Lipidic Lyotropic Liquid Crystals

et al. 2019

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Amphiphilic lipids aggregate in aqueous solution into a variety of structural arrangements. Among the plethora of ordered structures that have been reported, many have also been observed in nature. In addition, due to their unique morphologies, the hydrophilic and hydrophobic domains, very high internal interfacial surface area, and the multitude of possible order−order transitions depending on environmental changes, very promising applications have been developed for these systems in recent years. These include crystallization in inverse bicontinuous cubic phases for membrane protein structure determination, generation of advanced materials, sustained release of bioactive molecules, and control of chemical reactions. The outstanding diverse functionalities of lyotropic liquid crystalline phases found in nature and industry are closely related to the topology, including how their nanoscopic domains are organized. This leads to notable examples of correlation between structure and macroscopic properties, which is itself central to the performance of materials in general. The physical origin of the formation of the known classes of lipidic lyotropic liquid crystalline phases, their structure, and their occurrence in nature are described, and their application in materials science and engineering, biology, medical, and pharmaceutical products, and food science and technology are exemplified. Amphiphilic LipidsThe ORCID identification number(s) for the author(s) of this article can be found under https://doi.

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“…There has been recent interest in lipid systems that can form and maintain ordered liquid crystal structures [inverse bicontinuous cubic phases (V 2 ) and inverse hexagonal phases (H 2 )] in the gastrointestinal (GI) environment as a means of extending the duration of drug absorption. While triglyceride-based lipids transiently form these ordered structures in the aqueous environment of the GI tract during digestion [7,8], other lipids form these structures intrinsically in water and the structures persist on exposure to aqueous gastrointestinal environments. Generally, lipids that are readily and rapidly digestible in the GI tract exhibit rapid drug release while slowly digested or non-digestible lipids that form these structures have been shown to provide a delayed drug release profile [6,9].…”

Section: Introductionmentioning

confidence: 99%

Sustained absorption of delamanid from lipid-based formulations as a path to reduced frequency of administration

Ramirez

Pham

Clulow

et al. 2020

Drug Deliv. and Transl. Res.

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Delamanid is a poorly water-soluble drug currently being used for the treatment of tuberculosis. The high frequency of dosing leads to poor adherence for patients who live in lower economic and nomadic populations. Non-digestible self-assembling lipids as a formulation approach for poorly water-soluble drugs have previously been shown to extend the window of absorption through gastric retention. We hypothesise that this approach could lead to the reduction of dosing frequency for delamanid and thereby has potential to improve adherence. Formulations of delamanid were prepared in selachyl alcohol and phytantriol as non-digestible self-assembling lipid vehicles, and their behaviour was compared with reconstituted milk powder, as a digestible lipid-based formulation, and an aqueous suspension. The self-assembly of selachyl alcohol and phytantriol in aqueous media in the presence of delamanid was studied using small angle X-ray scattering and produced the inverse hexagonal (H2) and inverse bicontinuous cubic (V2) liquid crystal structures, respectively. The times at which maximum delamanid levels in plasma were observed (Tmax) after oral administration of the phytantriol, selachyl alcohol and reconstituted milk powder formulations of delamanid to rats were 27 ± 3, 20 ± 4 and 6.5 ± 1.0 h, respectively, compared with the aqueous suspension formulation with a Tmax of 3.4 ± 1 h, which confirms the hypothesis of an extended duration of absorption after administration in non-digestible self-assembling lipids. The digestion products of the triglycerides in the milk formulation increased the solubilisation of delamanid in the gastrointestinal tract, leading to an increase in exposure compared with the aqueous suspension formulation but did not significantly extend Tmax. Overall, the non-digestible nanostructured lipid formulations extended the duration of absorption of delamanid well beyond that from milk or suspension formulations.

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A closer look at the behaviour of milk lipids during digestion

Cited by 53 publications

References 27 publications

Revisiting dispersible milk-drug tablets as a solid lipid formulation in the context of digestion

Revisiting dispersible milk-drug tablets as a solid lipid formulation in the context of digestion

Nature‐Inspired Design and Application of Lipidic Lyotropic Liquid Crystals

Sustained absorption of delamanid from lipid-based formulations as a path to reduced frequency of administration

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