<p style='text-indent:20px;'>Disasters such as earthquakes, typhoons, floods and COVID-19 continue to threaten the lives of people in all countries. In order to cover the basic needs of the victims, emergency logistics should be implemented in time. Location-routing problem (LRP) tackles facility location problem and vehicle routing problem simultaneously to obtain the overall optimization. In response to the shortage of relief materials in the early post-disaster stage, a multi-objective model for the LRP considering fairness is constructed by evaluating the urgency coefficients of all demand points. The objectives are the lowest cost, delivery time and degree of dissatisfaction. Since LRP is a NP-hard problem, a hybrid metaheuristic algorithm of Discrete Particle Swarm Optimization (DPSO) and Harris Hawks Optimization (HHO) is designed to solve the model. In addition, three improvement strategies, namely elite-opposition learning, nonlinear escaping energy, multi-probability random walk, are introduced to enhance its execution efficiency. Finally, the effectiveness and performance of the LRP model and the hybrid metaheuristic algorithm are verified by a case study of COVID-19 in Wuhan. It demonstrates that the hybrid metaheuristic algorithm is more competitive with higher accuracy and the ability to jump out of the local optimum than other metaheuristic algorithms.</p>