A cluster of lung injury associated with home humidifier use: clinical, radiological and pathological description of a new syndrome

The role of NF-κB signaling pathway in polyhexamethylene guanidine phosphate induced inflammatory response in mouse macrophage RAW264.7 cells

“…In Korea, PHMG-phosphate was used as household disinfectant to prevent the microorganisms in humidifier. However, epidemiological studies reported that the use of humidifier disinfectant containing PHMG-phosphate was strongly associated with a cluster of interstitial lung disease (Hong et al, 2014). In a case-control study conducted by the Korea Centers for Disease Control and Prevention (2011), use of a humidifier disinfectant was found in 94.4% of the case patients and in 26.4% of control patients (odds ratio, 47.3; 95% CI: 6.0-369.7).…”

Thoraxat 70

“…Suissa et al 47 showed a rapid decline in health status in COPD after a second severe exacerbation, and a high death rate in the weeks after any severe exacerbation. They also chose two linked papers describing an outbreak of a new aggressive form of interstitial lung disease in Korea 48 49. A detailed epidemiological investigation attributed this to humidifier disinfectant, later confirmed by showing that the disease disappeared when the disinfectant was removed—a reminder of John Snow and the 1854 cholera epidemic.…”

Year in review 2014: basic science and epidemiology

“…The first described a case series30 of young adults with a devastating acute lung injury; the second31 the epidemiological investigation into its cause. The story began in early 2011 with the admission into the intensive care unit of a Seoul hospital of a cluster of patients with unaccountable respiratory failure.…”