In article number https://doi.org/10.1002/adma.201705759, Muhammad M. Hussain and co‐workers present a comprehensive review on the role of CMOS technology for advanced microfluidics‐based personalized healthcare applications. The advanced and reliable CMOS technology offers a miniaturization opportunity to integrate a broad spectrum of devices involving sensors, actuators, and definitely integrated circuits with standard microfluidic components and operations such as flow cytometry, polymerase chain reaction (PCR) tests, immunoassays, and blood chemistry with an overarching objective: affordability.