A CMOS image sensor with optical and potential dual imaging function for on-chip bioscientific applications

On-chip biofluorescence imaging inside a brain tissue phantom using a CMOS image sensor for in vivo brain imaging verification

“…Efforts to develop miniaturized systems have resulted in a variety of designs and implementations [2][3][4][5][6]. Recently, CMOS-based devices have shown viability as a new class of emerging micro sensing devices [7][8][9][10][11][12][13]. Some of these devices are increasingly being explored to fill a niche application, which involves fluorescence detection [14][15][16].…”

Overview of CMOS image sensor use in molecular diagnostics

“…CMOS sensor based various biomolecular diagnoses are carried out with different sensing principles on various sensing platforms and the sensor can be incorporated into the smartphone, laptop, computer or other portable clinical diagnostic devices. CMOS sensor involved in: protein array development for protein diagnosis [32], fluorescence detection for protein and peptide diagnosis [4], CMOS based detection of AgeAb interaction on nanoparticle substrate [6], chemiluminescence analysis for AgeAb diagnosis [33], microarray platform development for DNA, RNA hybridization [16], DNA array development for DNA analysis [34], integrated program for sequence analysis [35], PCR approach for DNA amplification [7], integrated platform for gas sensing [36] optical sensing imager for the bio-molecule detection [37], microscopic approach for biomarker detection [38], and color density analysis for blood glucose monitoring [39]. detection of various AgeAb interactions such as interferon gamma [49], C-reactive protein (CRP) [50], Troponin I [51], HIV [28], and hepatitis B (HBV) [52] and label free electrical detection of hTSH [53].…”

An ultrasensitive method of real time pH monitoring with complementary metal oxide semiconductor image sensor

“…In addition, CMOS integrated pH sensor has been utilized in DNA analysis [21] that proves the sensor is capable to apply in the biochemical analysis. CMOS image sensor integrated electric sensing functionality has performed as an optical pH sensor [22], multifunctional pH image sensor [23] and dual pH sensor [24]. This system contains temperature sensor, heat resistant, signal processing and control circuitry integrated on-chip platform [21], and few sensors are time-consuming process in pH monitoring.…”