In this paper, comparison of common gate-common source single ended and differential ended Low Noise Amplifier (LNA) for Cognitive Radio (CR) receiver is presented. LNA for CR receiver architectures operating over a frequency range of 50–900[Formula: see text]MHz is designed for narrow band applications. In this work, Noise figure (NF), Third-Order Intercept Point (IIP3), voltage gain and scattering parameters (SP) have been analyzed. The voltage gain is 10.16866[Formula: see text]dB for single ended and 29.21371[Formula: see text]dB for differential ended, NF is 1.012[Formula: see text]dB for single ended and 3.8[Formula: see text]dB for differential ended. Power gain (S21) obtained is 15.67481[Formula: see text]dB for single ended and 14.89[Formula: see text]dB for differential ended. Compression point is [Formula: see text][Formula: see text]dB for single ended and [Formula: see text][Formula: see text]dB for differential ended, Third-Order Intercept Point (IIP3) is 1.97705 for single ended and 5.01608[Formula: see text]dB for differential ended amplifier, respectively. The design has been implemented using CMOS technology with cadence virtuoso design environment/automation tools.