A cognitive-behavioral weight reduction program in the treatment of obstructive sleep apnea syndrome with or without initial nasal CPAP: a randomized study

Kajaste, Soili; Brander, Pirkko; Telakivi, T; Partinen, Markku; Mustajoki, Pertti

doi:10.1016/j.sleep.2003.07.007

Cited by 133 publications

(101 citation statements)

References 34 publications

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“…11 Similarly, addition of CPAP did not result in greater weight loss when used as adjunctive therapy for a behavioral weight loss program in OSA patients. 15 In two other randomized controlled studies of CPAP compared to sham CPAP, CPAP treatment for 12 weeks or 24 weeks also did not result in weight loss. 13,14 However, the latter four studies may have been inadequately powered to detect a small change in weight.…”

Section: Discussionmentioning

confidence: 94%

“…However, available evidence is confl icting, with two studies demonstrating CPAP users losing weight 8,9 while others observed either no change or increases in weight. [11][12][13][14][15] However, these studies have been retrospective, small in size, lacked a parallel control group, or were not blinded. Thus, it is unclear whether treatment of OSA with CPAP results in any changes in weight.…”

Section: S C I E N T I F I C I N V E S T I G a T I O N Smentioning

confidence: 99%

See 1 more Smart Citation

Impact of Treatment with Continuous Positive Airway Pressure (CPAP) on Weight in Obstructive Sleep Apnea

Quan

Budhiraja

Clarke

et al. 2013

Journal of Clinical Sleep Medicine

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Section: Discussionmentioning

confidence: 94%

Section: S C I E N T I F I C I N V E S T I G a T I O N Smentioning

confidence: 99%

Impact of Treatment with Continuous Positive Airway Pressure (CPAP) on Weight in Obstructive Sleep Apnea

Quan

Budhiraja

Clarke

et al. 2013

Journal of Clinical Sleep Medicine

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“…26 However, not all studies have shown a beneficial effect of CPAP therapy. 27 The effects of an intensive lifestyle intervention (ILI) in patients with type 2 diabetes with OSA, has also been studied, and compared to standard diabetes support and education (DSE). 25 Especially during the first four months of the trial, patients in the ILI group, received portion-controlled diets with an energy content of 1 200-1 500 kcal/day for those < 113.6 kg, and 1 500-1 800 kcal/day for those patients weighing ≥ 113.6 kg.…”

Section: Diet and Osamentioning

confidence: 99%

Obstructive sleep apnoea and obesity

Tintinger

Pretorius

Labadarios

2011

South African Journal of Clinical Nutrition

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The global obesity epidemic continues to gain momentum, and South Africa is one of those countries with an extremely high prevalence of obesity. The reported association between obstructive sleep apnoea (OSA) and obesity has resulted in a parallel increase in the incidence of OSA. Obesity and OSA interact by inducing systemic inflammation, metabolic aberrations and endocrine abnormalities, all of which predispose patients to atherosclerosis and cardiovascular disease. OSA is associated with a pro-inflammatory state, and increased serum C-reactive protein concentrations. Cardiovascular complications of OSA include myocardial infarction, stroke, congestive heart failure, hypertension and cardiac arrhythmias. The complications of OSA and obesity result in reduced quality of life, significant morbidity, and increased mortality, for untreated patients. OSA causes symptoms such as snoring, apnoea, excessive daytime sleepiness, and morning headaches, but 80-90% of patients are never diagnosed, or treated for their condition. Recognition of these symptoms, and referral of patients for a polysomnogram (home-or laboratory-based), expedites the diagnosis and therapy of OSA. While continuous positive airway pressure (CPAP) remains the mainstay of therapy, dietary measures are important, and should be implemented. Loss of weight can lead to significant reductions in the apnoea-hypopnoea index (AHI) of patients with OSA, and obese patients with OSA should aim for a 10% reduction in body weight.

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“…The magnitude of the decrease in AHI after weight loss was higher in patients with the most severe OSA. Current data show that weight reduction not only improves breathing pattern but also increases REM and deep sleep (up to 10% and 17%, respectively) as well as the AHI [43][44][45][46][47][48][49][50][51][52][53]. In a large population-based prospective cohort study of 690 persons, a 10% weight loss was correlated with a 26% decrease in AHI, showing that even minimal weight loss can be beneficial in patients with OSA [54].…”

Section: Weight Reductionmentioning

confidence: 99%

Non-positive airway pressure therapy for obstructive sleep apnea

Jafari

Roux

2012

Curr Respir Care Rep

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Obstructive sleep apnea (OSA) is a common disorder associated with cardiovascular morbidity. Various methods are offered to improve symptoms of OSA and its outcome. Although positive airway pressure is the most effective treatment for OSA, its clinical effectiveness is limited by patients' compliance. Other suggested treatments for OSA focus on expanding upper airway and reducing its collapsibility. For example, mandibular advancement device (MAD) achieves this goal by mechanically protruding the mandible. Other available treatments including weight reduction, positional therapy, drugs, nasal dilators, and nasal expiratory pressure device are clearly inferior to CPAP.

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A cognitive-behavioral weight reduction program in the treatment of obstructive sleep apnea syndrome with or without initial nasal CPAP: a randomized study

Cited by 133 publications

References 34 publications

Impact of Treatment with Continuous Positive Airway Pressure (CPAP) on Weight in Obstructive Sleep Apnea

Impact of Treatment with Continuous Positive Airway Pressure (CPAP) on Weight in Obstructive Sleep Apnea

Obstructive sleep apnoea and obesity

Non-positive airway pressure therapy for obstructive sleep apnea

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