A Cognitive Model of the Familial Transmission of Depression

Dong, Xiaofei; Liu, Juan; Oei, Tian P. S.; Cui, Lixia; Xiao, Jing

doi:10.1080/10926771.2018.1501456

Cited by 3 publications

(2 citation statements)

References 48 publications

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“…poor interpersonal functioning, adverse events; Jansen et al, 2016;Watters et al, 2013;Zimmermann et al, 2008), cognitive vulnerabilities (e.g. cognitive reactivity, anxiety sensitivity; Aldao et al, 2010;Dong et al, 2018), and certain personality traits (e.g. neuroticism; Kotov et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

Familial resemblance in mental health symptoms, social and cognitive vulnerability, and personality: A study of patients with depressive and anxiety disorders and their siblings

Sprang

Maciejewski

Milaneschi

et al. 2021

Journal of Affective Disorders

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Section: Introductionmentioning

confidence: 99%

Familial resemblance in mental health symptoms, social and cognitive vulnerability, and personality: A study of patients with depressive and anxiety disorders and their siblings

Sprang

Maciejewski

Milaneschi

et al. 2021

Journal of Affective Disorders

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“…neuroticism, introversion, external locus of control; Docherty et al 2017; Kotov, Gamez, Schmidt, & Watson, 2010) and depressive/anxiety cognitions (e.g. hopelessness, rumination, anxiety sensitivity; Aldao, Nolen-Hoeksema, & Schweizer, 2010; Dong, Liu, Oei, Cui, & Xiao, 2018; Gotlib, Joormann, & Foland-Ross, 2014; Maciejewski, Hillegers, & Penninx, 2018; Naragon-Gainey, 2010) have been suggested as endophenotypic traits underlying depression and anxiety. Yet, only neuroticism and social vulnerabilities, such as childhood trauma and negative life events, have been investigated in relation to FH, again with mixed results (neuroticism positively associated: Holma et al, 2011; not associated: Duggan, Sham, Minne, Lee, & Murray, 1998; social vulnerabilities positively associated: Jansen et al 2016; Zimmermann et al, 2008, not associated: Manfro et al 1996).…”

Section: Introductionmentioning

confidence: 99%

Familial risk for depressive and anxiety disorders: associations with genetic, clinical, and psychosocial vulnerabilities

et al. 2020

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Abstract Background In research and clinical practice, familial risk for depression and anxiety is often constructed as a simple Yes/No dichotomous family history (FH) indicator. However, this measure may not fully capture the liability to these conditions. This study investigated whether a continuous familial loading score (FLS), incorporating family- and disorder-specific characteristics (e.g. family size, prevalence of depression/anxiety), (i) is associated with a polygenic risk score (PRS) for major depression and with clinical/psychosocial vulnerabilities and (ii) still captures variation in clinical/psychosocial vulnerabilities after information on FH has been taken into account. Methods Data came from 1425 participants with lifetime depression and/or anxiety from the Netherlands Study of Depression and Anxiety. The Family Tree Inventory was used to determine FLS/FH indicators for depression and/or anxiety. Results Persons with higher FLS had higher PRS for major depression, more severe depression and anxiety symptoms, higher disease burden, younger age of onset, and more neuroticism, rumination, and childhood trauma. Among these variables, FH was not associated with PRS, severity of symptoms, and neuroticism. After regression out the effect of FH from the FLS, the resulting residualized measure of FLS was still associated with severity of symptoms of depression and anxiety, rumination, and childhood trauma. Conclusions Familial risk for depression and anxiety deserves clinical attention due to its associated genetic vulnerability and more unfavorable disease profile, and seems to be better captured by a continuous score that incorporates family- and disorder-specific characteristics than by a dichotomous FH measure.

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Linking Maternal Depression to Adolescent Internalizing Symptoms: Transmission of Cognitive Vulnerabilities

Dunning

McArthur

Abramson

et al. 2020

J Youth Adolescence

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A Cognitive Model of the Familial Transmission of Depression

Cited by 3 publications

References 48 publications

Familial resemblance in mental health symptoms, social and cognitive vulnerability, and personality: A study of patients with depressive and anxiety disorders and their siblings

Familial resemblance in mental health symptoms, social and cognitive vulnerability, and personality: A study of patients with depressive and anxiety disorders and their siblings

Familial risk for depressive and anxiety disorders: associations with genetic, clinical, and psychosocial vulnerabilities

Linking Maternal Depression to Adolescent Internalizing Symptoms: Transmission of Cognitive Vulnerabilities

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