Background and Aims: Substance use disorders (SUD) are associated with cognitive
deficits that are not always addressed in current treatments, and this hampers recovery.
Cognitive training and remediation interventions are well suited to fill the gap for managing
cognitive deficits in SUD. We aimed to reach consensus on recommendations for developing
and applying these interventions.
Design: Delphi approach with two sequential phases: survey development and iterative
surveying of experts.
Setting: Online study.
Participants: During survey development, we engaged a group of 15 experts from a working
group of the International Society of Addiction Medicine (Steering Committee). During the
surveying process, we engaged a larger pool of experts (n=53) identified via
recommendations from the Steering Committee and a systematic review.
Measurements: Survey with 67 items covering four key areas of intervention development,
i.e., targets, intervention approaches, active ingredients, and modes of delivery.
Findings: Across two iterative rounds (98% retention rate), the experts reached a consensus
on 50 items including: (i) implicit biases, positive affect, arousal, executive functions, and
social processing as key targets of interventions; (ii) cognitive bias modification, contingency
management, emotion regulation training, and cognitive remediation as preferred approaches;
(iii) practice, feedback, difficulty-titration, bias-modification, goal setting, strategy learning,
and meta-awareness as active ingredients; and (iv) both addiction treatment workforce and
specialized neuropsychologists facilitating delivery, together with novel digital-based
delivery modalities.
Conclusions: Expert recommendations on cognitive training and remediation for SUD
highlight the relevance of targeting implicit biases, reward, emotion regulation, and higher-
order cognitive skills via well-validated intervention approaches qualified with mechanistic
techniques and flexible delivery options.