A collaborative in vitro dissolution study using the flow-through method

What is a Suitable Dissolution Method for Drug Nanoparticles?

“…There was effective size and solubility discrimination as the nanoparticles clearly displayed an increased rate of dissolution over the unprocessed form as a result of the increased surface area and solubility. There was also less variability in the observed dissolution profiles, which was in close accordance to findings in the literature (23,43). These results thus provide direct evidence for the suitability of the flow-through cell for the analysis of nanoparticle dissolution.…”

MRI Studies of the Hydrodynamics in a USP 4 Dissolution Testing Cell

“…46 Other authors qualitatively described the enhanced dissolution rate of calibrating tablets as the operating flow rate was increased. [47][48][49] Morihara et al 50 inferred differences in the operating hydrodynamics of four compedial dissolution apparatuses in terms of the dissolution rate of salicylic acid calibrator tablets. Fyfe et al 35 were the only group to use in situ MRI to observe the effect of media flow rate on the rate of tablet erosion and drug release.…”

Using USP I and USP IV for Discriminating Dissolution Rates of Nano- and Microparticle-Loaded Pharmaceutical Strip-Films

“…The flow-through cell dissolution apparatus has been successfully used to study dissolution of different solid dosage forms including tablets, capsules, powders, suppositories, dispersed systems, implants, and microspheres (19)(20)(21)(22)(23)(24)(25)(26). This dissolution technique has been proven to be reproducible and robust, which is an important characteristic for dissolution testing (27)(28)(29). The increased sensitivity of the flow-through cell dissolution method related to particle size of a poorly soluble drug powder has also been reported recently (30,31).…”