“…Due to its large imaging area, fast acquisition speed, high resolution, good linear response, long-term measurement stability, and being mounted on the linac, EPID has been extensively used in IMRT and VMAT quality assurance [ 2 , 3 , 4 , 5 , 6 , 7 ], including pretreatment and in-vivo dose verification. Pretreatment dose verification usually involves the following two approaches: first, the fluence generated by the treatment planning system (TPS) is convolved with the kernel to predict the EPID image; then, the predicted image is compared with the measured EPID image for verification [ 8 , 9 , 10 ]. This method is widely used in clinics, but may not reflect the errors introduced in the TPS calculation process.…”