A collecting duct carcinoma producing carcinoembryonic antigen and Ca-125 in a 29-year-old woman

Abstract

Collecting duct carcinoma is a rare renal malignant neoplasm, arising from the medullary collecting duct and accounting for less than 1% of renal cell carcinomas. It is more common in middle-aged men and is usually presented with hematuria, abdominal mass and back or flank pain. Its immunohistochemical analysis detects the expression of various markers, such as low and high molecular weight keratins, Ulex europaeus agglutinin-1, epithelial membrane antigen and peanut lectin. Here, we present a case of a 29-year-old woman with CDC presented with back pain and supraclavicular lymphadenopathy that produced carcinoembryonic antigen and CA-125.

Cystic low-grade collecting duct renal carcinoma with liver compression — A challenging diagnosis and therapy: A case report

“…Suspicion of CDC should be confirmed by Hematoxylin-Eosin staining and positivity for UEA I and a large spectrum of keratins, such CKHMW, CK AE1/AE3, CK7, and CK19, associated with positivity for CD15. CDC is negative for CD10, CK20 and villin and might display vimentin and HER-2 expression[ 1 , 3 , 5 , 6 ]. HER-2 positivity, which was not identified in this case, is considered an indicator of poor prognosis[ 10 ].…”

“…It originates from the collecting duct epithelium, which is located in the renal medulla[ 3 ]. CDC has distinct clinical and pathological characteristics, such as hematuria, weight loss, back or flank pain and a local mass, but also fatigue and fever[ 2 - 6 ]. It mostly appears in middle-aged men (male-to-female ratio = 2:1), with a right-sided laterality predominance (> 2:1)[ 2 , 6 , 7 , 8 ].…”

“…CDC has distinct clinical and pathological characteristics, such as hematuria, weight loss, back or flank pain and a local mass, but also fatigue and fever[ 2 - 6 ]. It mostly appears in middle-aged men (male-to-female ratio = 2:1), with a right-sided laterality predominance (> 2:1)[ 2 , 6 , 7 , 8 ]. At the time of diagnosis, approximately one third of patients present with metastases in supraclavicular or cervical lymph nodes or distant metastases in the lungs, bones, liver or adrenal glands[ 2 , 4 , 6 , 7 , 9 ].…”