A Colorimetric Detection of Noradrenaline in Wastewater Using Citrate-Capped Colloidal Gold Nanoparticles Probe

Analytical methods for detecting neurotransmitters (NTs) and organophosphorus (OP) pesticides with high sensitivity are vitally necessary for the rapid identification of physical, mental, and neurological illnesses, as well as to ensure food safety and safeguard ecosystems. In this work, we developed a supramolecular self-assembled system (SupraZyme) that exhibits multi-enzymatic activity. SupraZyme possesses the ability to show both oxidase and peroxidase-like activity, which has been employed for biosensing. The peroxidase-like activity was used for the detection of catecholamine NTs, epinephrine (EP), and norepinephrine (NE) with a detection limit of 6.3 µM and 1.8 µM, respectively, while the oxidase-like activity was utilized for the detection of organophosphate pesticides. The detection strategy for OP chemicals was based on the inhibition of acetylcholine esterase (AChE) activity: a key enzyme that is responsible for the hydrolysis of acetylthiocholine (ATCh). The corresponding limit of detection of paraoxon-methyl (POM) and methamidophos (MAP) was measured to be 0.48 ppb and 15.8 ppb, respectively. Overall, we report an efficient supramolecular system with multiple enzyme-like activities that provide a versatile toolbox for the construction of sensing platforms for the colorimetric point-of-care detection of both NTs and OP pesticides.

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Asymmetric Pt(II)-Porphyrin Incorporated in a PVC Ion-Selective Membrane for the Potentiometric Detection of Citrate

Vlascici

Lascu

Fratilescu

et al. 2023

Chemosensors

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A new sensing material, Pt(II)-5-(4-carboxyphenyl)-10,15,20-tris(4-phenoxyphenyl)-porphyrin (Pt(II)-COOH-TPOPP), was synthesized and characterized. Polymeric membranes containing the porphyrin and three different plasticizers were used as an electroactive material for a new anion-selective sensor. The best composition of the membrane was the one plasticized with dioctylsebacate (DOS), the obtained sensor being citrate-selective in a linear range of 5 × 10−7–1 × 10−1 M citrate. The slope was Nernstian (19.73 mV/decade) with good selectivity towards a number of interfering anions and a lifetime of five weeks.

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A Colorimetric Detection of Noradrenaline in Wastewater Using Citrate-Capped Colloidal Gold Nanoparticles Probe

Cited by 3 publications

References 35 publications

Urine biomarkers for Alzheimer's disease: A new opportunity for wastewater-based epidemiology?

Urine biomarkers for Alzheimer's disease: A new opportunity for wastewater-based epidemiology?

Metal Coordination-Driven Supramolecular Nanozyme as an Effective Colorimetric Biosensor for Neurotransmitters and Organophosphorus Pesticides

Asymmetric Pt(II)-Porphyrin Incorporated in a PVC Ion-Selective Membrane for the Potentiometric Detection of Citrate

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