A combination of green tea, rhodiola, magnesium and B vitamins modulates brain activity and protects against the effects of induced social stress in healthy volunteers

Boyle, Neil Bernard; Billington, Jac; Lawton, Clare; Quadt, Frits; Dye, Louise

doi:10.1080/1028415x.2021.1909204

Cited by 21 publications

(49 citation statements)

References 44 publications

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“…All tasks were completed in sequential order in one session. The resting state data is reported elsewhere (5).…”

Section: Electroencephalogram Methodologymentioning

confidence: 99%

“…The effect of treatment on EEG spectral frequency oscillatory brain activity during the rested state [previously published (5)] and during completion of attentional tasks under conditions of stress exposure.…”

Section: Primary Outcomesmentioning

confidence: 99%

“…The effect of treatment on subjective state, salivary cortisol, cardiovascular parameters [previously published (5)], cognitive performance and attentional event related potentials (ERPs).…”

Section: Secondary Outcomesmentioning

confidence: 99%

“…One hundred healthy adults (men = 36; women = 64) were recruited from the University of Leeds and local community. Eligible participants were identified from responses to an online eligibility screening questionnaire [N = 535; the full CONSORT diagram is previously published (5)]. Inclusion and exclusion criteria were as follows:…”

Section: Participantsmentioning

confidence: 99%

“…Significant modulation of neural EEG activity has been demonstrated after acute intake of both green tea (1-3) and rhodiola (4). We have recently reported that combining green tea and rhodiola extract and administering with magnesium (Mg) and a B vitamin complex (B 6 , B 9 , and B 12 ) significantly increased resting state frontal midline theta activity under stress conditions compared to placebo, and rhodiola extract combined with Mg and B vitamins (5); post hoc exploratory analysis also demonstrated the combined treatments superiority to green tea in isolation combined with Mg and B vitamins. Increased frontal midline theta is associated with a relaxed, alert state and anxiolytic action (6) suggesting the combination of these ingredients has the potential to enhance coping capacity and offer protection from the impairing effects of stress exposure.…”

Section: Introductionmentioning

confidence: 99%

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A Combination of Green Tea, Rhodiola, Magnesium, and B Vitamins Increases Electroencephalogram Theta Activity During Attentional Task Performance Under Conditions of Induced Social Stress

et al. 2022

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BackgroundA combination of green tea, rhodiola and magnesium with B vitamins has previously been reported to significantly increase EEG resting state theta, attenuate subjective stress, anxiety and mood disturbance, and heighten subjective and autonomic arousal under acute psychosocial laboratory stress. Here we examine the capacity of green tea and rhodiola extract administered in combination or in isolation with magnesium and B vitamins to moderate spectral brain activity during attentional task performance under stress.Materials and MethodsOne-hundred moderately stressed adults received oral supplementation of (i) Mg + B vitamins + green tea + rhodiola; (ii) Mg + B vitamins + rhodiola; (iii) Mg + B vitamins + green tea; or (iv) placebo, in a double-blind, randomised, placebo-controlled, parallel-group design (Clinicaltrials.gov: NCT03262376; 25/0817). Participants completed an attention switching and emotionally threatening attentional bias task after stress induction (Trier Social Stress Test). Spectral alpha and theta brain activity and event related potentials (ERPs) were recorded during cognitive task performance by electroencephalogram (EEG; BioSemi ActiveTwo 64 channel).ResultsThe combined treatment of Mg + B vitamins + green tea + rhodiola significantly increased frontal midline theta vs. placebo and rhodiola in isolation during the attention switching task, specifically in anticipation of a change in task performance parameter. The combined treatment also significantly increased contralateral theta activation in relation to viewing emotionally threatening images in the left (vs. placebo and rhodiola in isolation) and right parietal (vs. placebo) regions. Further, this treatment demonstrated significantly heightened ipsilateral left parietal theta activation in relation to viewing emotionally threatening images. The combined treatment attenuated a decrease in alpha power during the attentional bias task evident in comparator treatments, but this did not reach significance. No significant effects of treatments on behavioural performance or ERP were found.ConclusionThe combination of Mg + B vitamins + green tea + rhodiola increased spectral theta brain activity during the execution of two attentional tasks suggestive of a potential to increase attentional capacity under conditions of stress. Further examination of these ingredients in relation to attentional performance under stress is warranted to ascertain if functional benefits suggested by theta activation can be shown behaviourally.

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“…All tasks were completed in sequential order in one session. The resting state data is reported elsewhere (5).…”

Section: Electroencephalogram Methodologymentioning

confidence: 99%

Section: Primary Outcomesmentioning

confidence: 99%

Section: Secondary Outcomesmentioning

confidence: 99%

Section: Participantsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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A Combination of Green Tea, Rhodiola, Magnesium, and B Vitamins Increases Electroencephalogram Theta Activity During Attentional Task Performance Under Conditions of Induced Social Stress

et al. 2022

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Rhodiola rosea: a review in the context of PPPM approach

Xu,

Yang,

Zhang

et al. 2024

EPMA Journal

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Botanical hybrid preparations (BHP) in phytomedicine and phytotherapy research: background and perspectives

Panossian,

Lemerond,

Efferth

2024

Preprint

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Background: The commonly known assumption that combinations of several herbs in one formulation can have better efficacy due to additive or synergistic effects has not been systematically studied despite some evidence supporting the synergy concept. Study aim: The study aimed to reveal the molecular interactions in situ of host cells in response to the intervention of BHP and justify the benefits of implementing BHP in clinical practice. Results: This overview provides the results of recent clinical and network pharmacology studies of botanical herbal preparations (BHP) of Rhodiola with other plants, including Ashwagandha, Green Tea, Eleutherococcus, Schisandra, Eleutherococcus, Leuzea, Caffeine, Cordyceps, Gingko, Black Cohosh, saffron, and L-carnosine. Conclusions: The most important finding from network pharmacology studies of BHP was the evidence supporting the synergistic interaction of BHP ingredients, revealing unexpected new pharmacological activities unique and specific to the new BHP. Some studies show the superior efficacy of BHP compared with mono-drugs. At the same time, some a priori-designed combinations can fail, presumably due to antagonistic interactions and crosstalk between molecular targets within molecular networks involved in the cellular and overall response of organisms on the intervention. Network pharmacology studies help predict the results of studies to discover new indications and unpredicted adverse events.

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A combination of green tea, rhodiola, magnesium and B vitamins modulates brain activity and protects against the effects of induced social stress in healthy volunteers

Abstract: Dye (2021): A combination of green tea, rhodiola, magnesium and B vitamins modulates brain activity and protects against the effects of induced social stress in healthy volunteers, Nutritional Neuroscience,

Cited by 21 publications

References 44 publications

A Combination of Green Tea, Rhodiola, Magnesium, and B Vitamins Increases Electroencephalogram Theta Activity During Attentional Task Performance Under Conditions of Induced Social Stress

A Combination of Green Tea, Rhodiola, Magnesium, and B Vitamins Increases Electroencephalogram Theta Activity During Attentional Task Performance Under Conditions of Induced Social Stress

Rhodiola rosea: a review in the context of PPPM approach

Botanical hybrid preparations (BHP) in phytomedicine and phytotherapy research: background and perspectives

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