A Combination of Heart Rate-Corrected QT Interval and GRACE Risk Score Better Predict Early Mortality in Patients with Non-ST Segment Elevation Acute Coronary Syndrome

Inci, Saadet Demirtas; Tekindal, Mustafa Agâh; Altınsoy, Meltem; Özbeyaz, Nail Burak; Sunman, Hamza; Taş, Alperen; Yılmaz, Şenol; Şengül, Sebahat Tekeli; Altın, Cihan; Güllü, Hakan

doi:10.5543/tkda.2022.21198

Cited by 4 publications

(1 citation statement)

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“…Early ventricular remodeling usually occurs 24–72 h after AMI and presents clinically as asymptomatic LVSD, but is underdiagnosed 5 , 7 . There are a number of clinical indicators that predict LVSD;copeptin was shown to be a valid indicator 16 ;heart rate-corrected QT interval prolongation to the Global Registry of Acute Coronary Events risk score improves the predictive value for early mortality in patients with acute coronary syndrome 17 ; Of course, there are many other methods of prediction, such as BNP, echocardiography, and magnetic resonance imaging,, but these approaches are expensive, cumbersome and cannot be monitored systematically. Moreover, many patients refused these tests to be performed.…”

Section: Discussionmentioning

confidence: 99%

Predictive value of acoustic cardiography for post-PCI early ventricular remodeling in acute myocardial infarction

Wang

Hao

Fan

et al. 2023

Sci Rep

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Acoustic cardiography is a completely new technology, it has great advantages in the rapid diagnosis of cardiovascular diseases. The purpose of this study was to investigate the clinical value of the fourth heart sound (S4), cardiac systolic dysfunction index (SDI), and the cardiac cycle time-corrected electromechanical activation time (EMATc) in the prediction of post-percutaneous coronary intervention (PCI) early ventricular remodeling (EVR) in patients with acute myocardial infarction (AMI). We recruited 161 patients with AMI of 72-h post-PCI, including 44 EVR patients with left ventricular ejection fraction (LVEF) < 50% and 117 Non-EVR patients (normal left ventricular systolic function group, LVEF ≥ 50%). EMATc, S4, and SDI were independent risk factors for post-PCI early ventricular remodeling in patients with AMI [S4 (OR 2.860, 95% CI 1.297–6.306, p = 0.009), SDI (OR 4.068, 95% CI 1.800–9.194, p = 0.001), and EMATc (OR 1.928, 95% CI 1.420–2.619, p < 0.001)]. The area under the receiver operating characteristic curve for EMATc was 0.89, with an optimal cutoff point of 12.2, EMATc had a sensitivity of 80% and a specificity of 83%. By contrast, an optimal cutoff point of 100 pg/ml, Serum brain natriuretic peptide had a sensitivity of 46% and a specificity of 83%. Our findings suggest the predictive value of EMATc for the occurrence of EVR in these patients was also identified; EMATc may be a simple, quick, and effective way to diagnose EVR after AMI.

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Section: Discussionmentioning

confidence: 99%

Predictive value of acoustic cardiography for post-PCI early ventricular remodeling in acute myocardial infarction

Wang

Hao

Fan

et al. 2023

Sci Rep

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Relationship between NT-proBNP levels and existing/ de novo QRS fragmentation in patients with myocardial infarction

Sunman,

Algül,

Dural

et al. 2024

Biomarkers in Medicine

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Correlation between corrected QT interval combined with NLR and MACE events within one year in patients with Chronic Heart Failure

REN

Liu

2022

Preprint

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Objective: To investigate the predictive value of corrected QT （QTc）interval and neutrophil to lymphocyte ratio (NLR) on major adverse cardiovascular events (MACE) in patients with chronic heart failure (CHF) within one year. Methods: Retrospective in January 2018 to June 2021 in Hebei province people's hospital of cardiovascular internal medicine in hospital patients with CHF, MACE grouped according to whether the patients within 1 year, collect patients clinical data, electrocardiogram (ECG) index, other auxiliary examination and medications, for all the patients by telephone, follow-up outpatient care or electronic medical records, The incidence of MACE within 1 year after discharge was followed up. Multivariate Logistic regression analysis was used to explore the influencing factors of MACE events in patients within 1 year. ROC was used to analyze the predictive value of QTc interval NLR and their combination on the occurrence of MACE in patients with CHF within 1 year. Results: A total of 622 patients were enrolled, including 371 in the MACE group and 251 in the non-MACE group. Compared with the non-MACE group, the MACE group had higher age, proportion of cerebral infarction, QRS duration, QT interval, QTc interval, neutrophil count, NLR, creatinine, treatments with beta-blockers, aldosterone antagonists rate， and lower admission heart rate, ventricular rate, lymphocyte count, and hemoglobin content (P＜0.05).Multivariate Logistic regression analysis showed that age, admission heart rate, QTc interval, NLR and beta-blocker use rate are the influencing factors of MACE events(P＜0.05). ROC analysis estimating the performance in predicting the occurrence of MACE within 1 year in patients with showed that the area under curve（AUC）of QTc interval, score was 0.652（95%CI：0.609-0.695，P＜0.001） with 0.624 sensitivity and 0.61 specificity when the optimal cut-off value was determined as 428.5，the AUC of NLR was 0.649（95%CI：0.605-0.692，P＜0.001）with 0.523 sensitivity and 0.738 specificity when the optimal cut-off value was determined as 4.016， and the AUC of QTc interval and NLR was 0.719（95%CI：0.678-0.760，P＜0.001）with 0.679 sensitivity and 0.695 specificity when the optimal cut-off value was determined as 0.583. Conclusion: Prolongation of QTc interval and elevation of NLR may be independent risk factors for MACE in CHF patients within 1 year, and their combination can be used as predictors of MACE in CHF patients within 1 year.

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A Combination of Heart Rate-Corrected QT Interval and GRACE Risk Score Better Predict Early Mortality in Patients with Non-ST Segment Elevation Acute Coronary Syndrome

Cited by 4 publications

References 0 publications

Predictive value of acoustic cardiography for post-PCI early ventricular remodeling in acute myocardial infarction

Predictive value of acoustic cardiography for post-PCI early ventricular remodeling in acute myocardial infarction

Relationship between NT-proBNP levels and existing/ de novo QRS fragmentation in patients with myocardial infarction

Correlation between corrected QT interval combined with NLR and MACE events within one year in patients with Chronic Heart Failure

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