A Combination of <i>Scutellaria Baicalensis</i> and <i>Acacia Catechu</i> Extracts for Short-Term Symptomatic Relief of Joint Discomfort Associated with Osteoarthritis of the Knee

Arjmandi, Bahram H.; Ormsbee, Lauren; Elam, Marcus L.; Campbell, Sara C.; Rahnama, Nader; Payton, Mark E.; Brummel-Smith, Ken; Daggy, Bruce P.

doi:10.1089/jmf.2013.0010

Cited by 34 publications

(25 citation statements)

References 34 publications

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“…OA resulted in destruction of articular cartilage which ends with impaired joint motion and disability (Arjmandi et al, 2014). Many causative aspects contributed in OA development; some of them are inflammation, proteinases and reactive oxygen or nitrogen species (ROS/RNS) generation which ultimately led to synovitis (Berenbaum, 2013;Narayani et al, 2014;Ferrándiz et al, 2015;Jeong et al, 2015).…”

Section: Discussionmentioning

confidence: 99%

Prospective Effect of Red Algae,actinotrichia Fragilis, Against Some Osteoarthritisaetiology

Sayed¹,

Sadek²,

Soliman³

et al. 2016

AJTCAM

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Background: Osteoarthritis (OA) is a progressive disease characterized by joints pain and articular cartilage destruction. Most of the current treatment strategies for OA are effective for symptoms relief but are accompanied with adverse side effect. Thus, the present investigation aims to evaluate the potential influence of red algae, Actinotrichia fragilis, in the dry powder form (AFP) or gel form (AFG) on some relevant factors of OA progression as well as assess its safety through in vitro and in vivo experiments. Materials and Methods: In vitro, AFP was analyzed for its chemical constituents screening, amino acid, proteinase inhibitory activity, HRBC membrane stabilization activity, free radical scavenging activity, total antioxidant potency, nitric oxide radical scavenging power. In vivo, Organization for Economic Co-operation and Development (OECD) toxicity test was performed to test the safety of AFP on rats.Results: The present findings revealed that AFP and AFG can be considered as inflammatory-proteinase-oxidant inhibitor and considered to be safe according to the OECD guideline. Conclusion: AFP and AFG may have the potency to become the therapeutic candidate for OA disease as it prevents the key causes of OA initiation.

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Section: Discussionmentioning

confidence: 99%

Prospective Effect of Red Algae,actinotrichia Fragilis, Against Some Osteoarthritisaetiology

Sayed¹,

Sadek²,

Soliman³

et al. 2016

AJTCAM

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“…Finally, 11 clinical trials investigating a total of 7 different plant extracts were selected and are reviewed in the following section [12][13][14][15][16][17][18][19][20][21][22]. Key parameters of the trials are summarized in Table 1.…”

Section: Pubmed Literature Surveymentioning

confidence: 99%

“…The authors concluded that UP446 was safe and may represent an efficient alternative medication for symptomatic OA. A recent study performed by Arjmandi et al investigated the early effects of UP446 intake on joint pain, mobility, and biomarkers of inflammation in OA [14]. A total of 79 men and women suffering from mild to moderate OA were included.…”

Section: Scutellaria Baicalensis and Acacia Catechu Extract (Flavocoxmentioning

confidence: 99%

Medical Plant Extracts for Treating Knee Osteoarthritis: a Snapshot of Recent Clinical Trials and Their Biological Background

2015

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In light of the growing global health problem associated with osteoarthritis, herbal remedies have become an important research focus in the scientific and medical community, and numerous studies have been published to identify their biological effects and mechanisms in vitro and in vivo. This review is a snapshot of the most recent clinical trials on the efficacy of medical plant extracts in knee osteoarthritis patients, and provides relevant background information on the biological mechanisms that may underlie the clinical observations. Therefore, we performed a PubMed literature survey and discussed a selection of clinical trials in the field, with special attention being drawn to the design and outcome measures of the studies. We further spotlighted on issues relating to the efficacy and safety of the plant extracts and discussed major challenges for upcoming studies in the field, which include the need for rigorously designed in vivo and in vitro studies, as well as the elucidation of potential additive effects and structure-modifying activities beyond symptom relief.

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“…In combination, standardize to give a composition designated as UP446, they have been used as a joint care dietary supplements. In recent years, substantial reports have been documented to address the beneficial use of UP446 in current osteoarthritis management modalities compared with pharmaceutic grade therapeutics in humans and were found promising (Levy et al, 2009;Sampalis and and Brownell, 2012;Arjmandi et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

Reproductive and Developmental Toxicity of Orally Administered Botanical Composition, UP446‐Part III: Effects on Fertility and Early Embryonic Development to Implantation in Sprague Dawley Rats

Yimam

Lee²,

Hyun³

et al. 2015

Birth Defects Research Pt B

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In recent years, high prevalence of adverse effects associated to the use of traditional medicines during pregnancy is becoming alarming due to the self-medication of oral supplements by expecting mothers without supervision. Many expectant mothers use alternative and complementary medicines as a supplement to conventional pregnancy management with an inherent belief of considering herbal remedies as harmless. To the contrary, herbal remedies could incur a potential teratogenic risk both to the child bearing mother and the developing fetuses when consumed before or at the time of gestation. Here, we describe the potential adverse effects of orally administered UP446, a standardized bioflavonoid composition from the roots of Scutellaria baicalensis and the heartwoods of Acacia catechu, on fertility and early embryonic development to implantation in Sprague Dawley rats at doses of 250, 500, and 1000 mg/kg. Besides body weight and food consumption, reproductive functions, sperm motility and morphology, estrus cycle, and fertility rate were monitored. There were no statistically significant differences in reproductive function in all UP446 treated groups in both genders. Test substance impacts on reproductive parameters were very minimal. Neither sperm motility nor morphology was affected as a result of oral UP446 administrations in males. There were no treatment-related effects on estrus cycle stages in females. No significant changes in necropsy or histopathology were observed for all the groups. Therefore, the no observed adverse effect level (NOAEL) of UP446 was considered to be 1000 mg/kg, the highest dose tested, in both genders.

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A Combination of Scutellaria Baicalensis and Acacia Catechu Extracts for Short-Term Symptomatic Relief of Joint Discomfort Associated with Osteoarthritis of the Knee

Cited by 34 publications

References 34 publications

Prospective Effect of Red Algae,actinotrichia Fragilis, Against Some Osteoarthritisaetiology

Prospective Effect of Red Algae,actinotrichia Fragilis, Against Some Osteoarthritisaetiology

Medical Plant Extracts for Treating Knee Osteoarthritis: a Snapshot of Recent Clinical Trials and Their Biological Background

Reproductive and Developmental Toxicity of Orally Administered Botanical Composition, UP446‐Part III: Effects on Fertility and Early Embryonic Development to Implantation in Sprague Dawley Rats

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