A combination of laser-assisted ALA-PDT for squamous cell carcinoma in situ and field-directed ALA-PDT for actinic keratosis

Shen, Shuzhan; Liu, Xiaojing; Yang, Xiaoqin; Hu, Chan; Wang, Peiru; Wang, Xiuli

doi:10.1016/j.pdpdt.2021.102638

Cited by 2 publications

(2 citation statements)

References 6 publications

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“…While it is understandable why many dermatologists do not feel comfortable using lasers for the management of invasive SCC, laser therapy may be suitable for treating SCC in situ (SCCis). The authors identified 13 studies evaluating the use of lasers alone 7,23,[44][45][46][47][48][49][50][51] or in combination with PDT 39,51,52 for the management of SCCis (Table 1). Case reports using PDL and thulium lasers separately reported 100% clearance rates of SCCis 7,43 while several case series (samples size #44) demonstrated variable efficacy of CO 2 in the treatment of SCCis, with response rates ranging from 61.5% to 100%.…”

Section: Laser Therapy For Squamous Cell Carcinomasmentioning

confidence: 99%

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Lasers for the Treatment of Nonmelanoma Skin Cancer: A Systematic Review of the Literature

Rosenthal,

Juhasz,

Chang

et al. 2024

Dermatol Surg

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BACKGROUND Lasers may present an alternative treatment modality for the management of nonmelanoma skin cancer (NMSC). OBJECTIVE To investigate lasers as a definitive treatment of NMSC. METHODS A comprehensive search was performed on MEDLINE, the Cochrane Library, and the National Institutes of Health (www.clinicaltrials.gov). The Preferred Reporting Items for Systematic Reviews and Meta-Analysis was used to finalize a list of relevant literature studies evaluating the role of laser therapy for NMSC. Articles published through May 1, 2023, were included. RESULTS The authors identified 37 studies investigating nonablative and ablative lasers alone and in combination with other lasers, noninvasive imaging, and additional modalities for the treatment of basal cell carcinomas, 10 focusing on squamous cell carcinoma in situ and 3 focusing on the treatment of both basal and squamous cell carcinomas. CONCLUSION Although surgical management continues to be superior to laser therapy for the management of high-risk and cosmetically sensitive tumors, laser therapy may be an acceptable alternative for low-risk lesions on the trunk and extremities. However, further studies are needed to optimize parameters, determine maximal efficacy, and provide long-term follow-up before the adoption of laser therapy for NMSC into daily clinical practice.

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Section: Laser Therapy For Squamous Cell Carcinomasmentioning

confidence: 99%

“…Two minor investigations and 1 intraindividual comparison study found 80% to 100% tumor clearance while using CO 2 and Er:YAG, respectively, followed by PDT. 39,51,52 Data on the use of lasers for SCCis are limited, and further investigations are required.…”

Section: Laser Therapy For Squamous Cell Carcinomasmentioning

confidence: 99%

Lasers for the Treatment of Nonmelanoma Skin Cancer: A Systematic Review of the Literature

Rosenthal,

Juhasz,

Chang

et al. 2024

Dermatol Surg

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Nanomedicine‐Enabled Sonomechanical, Sonopiezoelectric, Sonodynamic, and Sonothermal Therapy

et al. 2023

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Nanomedicine‐enabled/augmented ultrasound (US) medicine is a unique area of interdisciplinary research that focuses on designing and engineering functional nanosystems to address the challenging issues in US‐based biomedicine, overcoming the shortcomings of traditional microbubbles and optimizing the design of contrast and sonosensitive agents. The single‐faceted summary of available US‐related therapies is still a significant drawback. Here, The proposal of a comprehensive review on the recent advances of sonosensitive nanomaterials in advancing four US‐related biological applications and disease theranostics is aimed. In addition to the mostly explored nanomedicine‐enabled/augmented sonodynamic therapy (SDT), the summary and discussion of other sono‐therapies and progresses/achievements are relatively lacking, including sonomechanical therapy (SMT), sonopiezoelectric therapy (SPT), and sonothermal therapy (STT). The design concepts of the specific sono‐therapies based on nanomedicines are initially introduced. Furthermore, the representative paradigms for nanomedicine‐enabled/enhanced US therapies are elaborated according to therapeutic principles and diversity. This review provides an updated and comprehensive review of the field of nanoultrasonic biomedicine, and comprehensively discusses the progress of versatile ultrasonic disease treatments. Finally, the deep discussion on the facing challenges and prospects is expected to promote the emergence and establishment of a new branch of US biomedicine through the rational combination of nanomedicine and US clinical biomedicine.

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A combination of laser-assisted ALA-PDT for squamous cell carcinoma in situ and field-directed ALA-PDT for actinic keratosis

Cited by 2 publications

References 6 publications

Lasers for the Treatment of Nonmelanoma Skin Cancer: A Systematic Review of the Literature

Lasers for the Treatment of Nonmelanoma Skin Cancer: A Systematic Review of the Literature

Nanomedicine‐Enabled Sonomechanical, Sonopiezoelectric, Sonodynamic, and Sonothermal Therapy

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