A Combination of Mediterranean and Low-FODMAP Diets for Managing IBS Symptoms? Ask Your Gut!

Kasti, Arezina N.; Petsis, Konstantinos; Lambrinou, Sophia; Katsas, Konstantinos; Nikolaki, Maroulla D.; Papanikolaou, Ioannis S.; Hatziagelaki, Erifili; Triantafyllou, Konstantinos

doi:10.3390/microorganisms10040751

Cited by 14 publications

(20 citation statements)

References 63 publications

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“…This was unexpected since IBS dietary recommendations suggest that a diet low in fermentable oligosaccharides, disaccharides, monosaccharides, and polyols (FODMAP) is used to manage IBS symptoms. However, it is possible that the anti-inflammatory properties of the Mediterranean diet helped in pain management among IBS patients [ 55 ].…”

Section: Discussionmentioning

confidence: 99%

Association between Serum Vitamin D and Irritable Bowel Syndrome Symptoms in a Sample of Adults

et al. 2022

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Vitamin D may be associated with irritable bowel syndrome (IBS) pathways. This cross-sectional study evaluated the associations between serum Vitamin D and IBS symptoms in a sample of Lebanese adults. Participants (n = 230; mean (SD) age: 43.36 (16.05) years, 62.9% females) were adults, free of diseases affecting Vitamin D metabolism, and recruited from a large university and the surrounding community. Serum Vitamin D (25-hydroxyvitamin D) was assessed using an automated chemiluminescence micro-particle immunoassay kit. The Birmingham IBS Symptom Questionnaire total scale, and pain, constipation, and diarrhea subscales were used to study IBS symptoms. Four linear regression analyses were performed, taking respectively the total scale and each of the subscales as the dependent variable. Vitamin D was forced into each model. Covariates included sociodemographic and medical variables, fluid intake, physical activity, sleep quality, stress, and adherence to the Mediterranean diet. Mean (SD) serum Vitamin D was 17.53 (12.40) ng/mL and mean (SD) Birmingham IBS Symptom Questionnaire was 16.98 (15.16) (pain: 20.75 (23.63), constipation: 25.06 (29.99), diarrhea: 9.88 (13.37)). Serum Vitamin D was not associated with the total score, nor with any of the subscales (p > 0.05 for the four regression analyses). Serum Vitamin D was not associated with IBS symptoms in a sample of Lebanese adults, adding to the controversy in this field. Further understanding of the pathophysiological mechanisms involved in Vitamin D and IBS is warranted.

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Section: Discussionmentioning

confidence: 99%

Association between Serum Vitamin D and Irritable Bowel Syndrome Symptoms in a Sample of Adults

et al. 2022

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“…Initially, the respondents showed greater saccharolytic activity of the microbiota as opposed to the non-respondents [ 122 ]. The optimal solution may be the use of the complete low FODMAPs diet protocol followed by extension to the Mediterranean diet [ 123 ]. It is still not known how LFD affects liver function in patients with NAFLD, and further studies are needed.…”

Section: Nutrition—what Is Beyond the Obvious?mentioning

confidence: 99%

Small Intestinal Bacterial Overgrowth and Non-Alcoholic Fatty Liver Disease: What Do We Know in 2023?

Gudan

Kozłowska-Petriczko

Bodnarczuk³

et al. 2023

Nutrients

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Non-alcoholic fatty liver disease (NAFLD) is a chronic liver disease associated with the pathological accumulation of lipids inside hepatocytes. Untreated NAFL can progress to non-alcoholic hepatitis (NASH), followed by fibrosis, cirrhosis, and hepatocellular carcinoma (HCC). The common denominator of the above-mentioned metabolic disorders seems to be insulin resistance, which occurs in NAFLD patients. Obesity is the greatest risk factor for lipid accumulation inside hepatocytes, but a part of the NAFLD patient population has a normal body weight according to the BMI index. Obese people with or without NAFLD have a higher incidence of small intestinal bacterial overgrowth (SIBO), and those suffering from NAFLD show increased intestinal permeability, including a more frequent presence of bacterial overgrowth in the small intestine (SIBO). The health consequences of SIBO are primarily malabsorption disorders (vitamin B12, iron, choline, fats, carbohydrates and proteins) and bile salt deconjugation. Undetected and untreated SIBO may lead to nutrient and/or energy malnutrition, thus directly impairing liver function (e.g., folic acid and choline deficiency). However, whether SIBO contributes to liver dysfunction, decreased intestinal barrier integrity, increased inflammation, endotoxemia and bacterial translocation is not yet clear. In this review, we focus on gut–liver axis and discuss critical points, novel insights and the role of nutrition, lifestyle, pre- and probiotics, medication and supplements in the therapy and prevention of both SIBO and NAFLD.

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“…Quinine alkaloids obtained from the bark of Cinchona trees have been used as anti-malarial drugs. Evidence gathered from several studies suggests its efficacy against viral infections and can be a potent candidate for treating covid infections [118,119].…”

Section: Natural Small Molecules and Functional Foods Against Covid-1...mentioning

confidence: 99%

Functional Foods: A Promising Strategy for Restoring Gut Microbiota Diversity Impacted by SARS-CoV-2 Variants

Banerjee¹,

Somasundaram²,

Das³

et al. 2023

Preprint

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Natural herbs and functional foods contain bioactive molecules capable of augmenting the immune system and mediating anti-viral functions. Functional foods, such as prebiotics, probiotics, and dietary fibers, have been shown to have positive effects on gut microbiota diversity and immune function. The use of functional foods has been linked with en-hanced immunity, regeneration, improved cognitive function, maintenance of gut mi-crobiota, and significant improvement in overall health. The gut microbiota plays a critical role in maintaining overall health and immune function, and disruptions to its balance have been linked to various health problems. SARS-CoV-2 infection has been shown to affect gut microbiota diversity, and the emergence of variants poses new challenges to combat the virus. SARS-CoV-2 recognizes and infects human cells through ACE2 receptors prevalent in lung and gut epithelial cells. Humans are prone to SARS-CoV-2 infection because the respiratory and gastrointestinal tracts are rich in microbial diversity and contain high ACE2 and TMPRSS2. This review article explores the potential use of functional foods in mitigating the impact of SARS-CoV-2 variants on gut microbiota diversity and the potential use of functional foods as a strategy to combat these effects.

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A Combination of Mediterranean and Low-FODMAP Diets for Managing IBS Symptoms? Ask Your Gut!

Cited by 14 publications

References 63 publications

Association between Serum Vitamin D and Irritable Bowel Syndrome Symptoms in a Sample of Adults

Association between Serum Vitamin D and Irritable Bowel Syndrome Symptoms in a Sample of Adults

Small Intestinal Bacterial Overgrowth and Non-Alcoholic Fatty Liver Disease: What Do We Know in 2023?

Functional Foods: A Promising Strategy for Restoring Gut Microbiota Diversity Impacted by SARS-CoV-2 Variants

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