A combined [11C]diprenorphine PET study and fMRI study of acupuncture analgesia

Dougherty, Darin D.; Kong, Jian; Webb, Megan; Bonab, Ali; Fischman, Alan J.; Gollub, Randy L.

doi:10.1016/j.bbr.2008.04.020

Cited by 83 publications

(80 citation statements)

References 46 publications

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“…The four studies which compared verum acupuncture with the Streitberger Needle were all from the US and showed heterogeneous results [16,19,21,22]. Yoo et al [16] found more activation associated with verum acupuncture in the somatosensory areas and motor areas.…”

Section: Study Characteristicsmentioning

confidence: 99%

Characterizing acupuncture stimuli using brain imaging with fMRI – a systematic review and meta-analysis of the literature

Huang

Pach

Napadow

et al. 2012

Deutsche Zeitschrift für Akupunktur

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Background: The mechanisms of action underlying acupuncture, including acupuncture point specificity, are not well understood. In the previous decade, an increasing number of studies have applied fMRI to investigate brain response to acupuncture stimulation. Our aim was to provide a systematic overview of acupuncture fMRI research considering the following aspects: 1) differences between verum and sham acupuncture, 2) differences due to various methods of acupuncture manipulation, 3) differences between patients and healthy volunteers, 4) differences between different acupuncture points.

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Section: Study Characteristicsmentioning

confidence: 99%

Characterizing acupuncture stimuli using brain imaging with fMRI – a systematic review and meta-analysis of the literature

Huang

Pach

Napadow

et al. 2012

Deutsche Zeitschrift für Akupunktur

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“…Here, we will focus on the regions most commonly associated with Neuroticism and Extraversion across studies: the insular cortex, OFC, amygdala, and ventral striatum. The literature suggests there is a substantial density of opioid receptors in all four of these regions, which enables us to detect whether opioid receptor binding potential, a proxy of baseline opioid function, is correlated with Neuroticism and Extraversion [31,32]. We hypothesized that opioid receptor binding potential in these regions would vary as a function of Neuroticism and Extraversion.…”

Section: Introductionmentioning

confidence: 99%

A Preliminary Study of the Opioid System and Personality Traits Using Positron Emission Tomography

et al. 2017

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Background: Personality traits, such as Neuroticism and Extraversion, have been implicated in the processing of emotion. The neural correlates most often associated with Neuroticism and Extraversion are the insular cortex, orbitofrontal cortex, amygdala, and ventral striatum. Objective: The aim of the current study was to explore neurotransmitter systems underlying those neural correlates and investigate the relationship between personality traits and opioid receptor binding potential. Method: Twelve healthy participants completed an [11C]diprenorphine positron emission tomography scan at rest. Endogenous opioid levels as indicated by opioid receptor binding potential was examined in relation to personality phenotype. Results: A high score of Neuroticism, a personality trait characterized by negative affect, was found to be associated with high opioid receptor binding in the right anterior insula. Conversely, a high score of Extraversion, a personality trait characterized by positive affect, was found to be associated with low opioid receptor binding in the left posterior insula. Conclusions: While preliminary, the results of this study suggest that the expression of Neuroticism and Extraversion is related to baseline function of the opioid neurotransmitter system in the insular cortex. These findings may help elucidate the neural mechanisms underlying the expression of personality traits, particularly those implicated in affective processing.

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“…It is becoming more common to acquire multimodality neuroimaging data that include PET and fMRI, as well as other types of MR (and optical) outcomes (Apkarian et al, 2005;Catana et al, 2008;Dougherty et al, 2008;Herzog et al, 2011;Huppert et al, 2008;Newberg et al, 2005;Rabiner et al, 2011;Sperling et al, 2009;Tong et al, 2011). Combined fMRI and PET brain imaging will become even more commonplace with the increased availability of combined PET/MR imaging systems.…”

Section: Multimodality Imagingmentioning

confidence: 99%

Molecular Brain Imaging in the Multimodality Era

Price

2012

J Cereb Blood Flow Metab

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Multimodality molecular brain imaging encompasses in vivo visualization, evaluation, and measurement of cellular/molecular processes. Instrumentation and software developments over the past 30 years have fueled advancements in multimodality imaging platforms that enable acquisition of multiple complementary imaging outcomes by either combined sequential or simultaneous acquisition. This article provides a general overview of multimodality neuroimaging in the context of positron emission tomography as a molecular imaging tool and magnetic resonance imaging as a structural and functional imaging tool. Several image examples are provided and general challenges are discussed to exemplify complementary features of the modalities, as well as important strengths and weaknesses of combined assessments. Alzheimer's disease is highlighted, as this clinical area has been strongly impacted by multimodality neuroimaging findings that have improved understanding of the natural history of disease progression, early disease detection, and informed therapy evaluation.

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A combined [11C]diprenorphine PET study and fMRI study of acupuncture analgesia

Cited by 83 publications

References 46 publications

Characterizing acupuncture stimuli using brain imaging with fMRI – a systematic review and meta-analysis of the literature

Characterizing acupuncture stimuli using brain imaging with fMRI – a systematic review and meta-analysis of the literature

A Preliminary Study of the Opioid System and Personality Traits Using Positron Emission Tomography

Molecular Brain Imaging in the Multimodality Era

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