A combined analysis of bulk and single-cell sequencing data reveals metabolic enzyme, pyruvate dehydrogenase E1 subunit beta (PDHB), as a prediction biomarker for the tumor immune response and immunotherapy

Zhang, Fan; Yan, Yuanliang; Liang, Qiuju; Liu, Yuanhong; Wu, Geting; Xu, Zhijie; Yang, Keda

doi:10.1016/j.heliyon.2023.e13456

Cited by 7 publications

(2 citation statements)

References 36 publications

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“…PDHB expression is upregulated early in peripheral nerve injury and promotes peripheral axon regeneration by regulating energy supply (Jiang et al 2023). Study identi es PDHB as a biomarker for predicting tumor immune response and immunotherapy (Zhang et al 2023). PDHB was less expressed in the NP group compared to the SHAM1 group, indicating mitochondrial dysregulation, an important clinical therapeutic target.…”

Section: Discussionmentioning

confidence: 99%

Mitochondrial Dysfunction and Disulfidptosis Co-regulate Neuronal cell in Neuropathic Pain Based on Bioinformatics Analysis

Ge,

Song,

Tao

et al. 2024

Preprint

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Neuropathic pain affects approximately 6.9-10% of the world's population and necessitates the development of novel treatments. Mitochondria are essential in the regulation of cell death. Neuroimmune mechanisms are implicated in various forms of cell death associated with neuropathic pain. However, the specific involvement of mitochondrial dysfunction and disulfidptosis in neuropathic pain remains uncertain. Further research is required to gain a better understanding of their combined contribution. Our comprehensive study employs a variety of bioinformatic analysis methods, including differential gene analysis, weighted gene co-expression network analysis, machine learning, functional enrichment analysis, immune infiltration, sub-cluster analysis, single-cell dimensionality reduction and cell-cell communicationto gain insight into the molecular mechanisms behind these processes. Our study rationally defines a list of key gene sets for mitochondrial dysfunction and disulfidptosis. 6 hub mitochondrial genes and 3 disulfidptosis-related genes (DRGs) were found to be associated with NP. The key genes were predominantly expressed in neurons and were lowly expressed in the NP group compared to SHAM. In addition, our macrophages used the APP-CD74 pathway to interact with neurons. These results suggest that NP is interconnected with the mechanistic processes of mitochondrial dysfunction and disulfidptosis, which may contribute to clinically targeted therapies.

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Section: Discussionmentioning

confidence: 99%

Mitochondrial Dysfunction and Disulfidptosis Co-regulate Neuronal cell in Neuropathic Pain Based on Bioinformatics Analysis

Ge,

Song,

Tao

et al. 2024

Preprint

View full text Add to dashboard Cite

show abstract

“…Pdhb is the key rate-limiting enzyme that decarboxylates glucose-derived pyruvate to form acetyl-CoA during the oxidative phosphorylation process of the body. 22 Pdhα1 is a carrier gene encoding an essential subunit of pyruvate dehydrogenase-1, a hub connecting glycolysis and TCA cycle, and a key gene for energy regulation. 23 Studies have shown that Pdhα1 gene deficiency can cause Leigh syndrome, lactate accumulation in the neuromuscular system, tumorigenesis, etc.…”

Section: Discussionmentioning

confidence: 99%

Identification of potential crucial cuproptosis-related genes in myocardial ischemia-reperfusion injury through the bioinformatic analysis

Huang,

Xu,

Zhang

et al. 2024

Clinics

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Identification of immune characteristic biomarkers and therapeutic targets in cuproptosis for sepsis by integrated bioinformatics analysis and single-cell RNA sequencing analysis

Wang,

Fang,

Sheng

et al. 2024

Heliyon

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A combined analysis of bulk and single-cell sequencing data reveals metabolic enzyme, pyruvate dehydrogenase E1 subunit beta (PDHB), as a prediction biomarker for the tumor immune response and immunotherapy

Cited by 7 publications

References 36 publications

Mitochondrial Dysfunction and Disulfidptosis Co-regulate Neuronal cell in Neuropathic Pain Based on Bioinformatics Analysis

Mitochondrial Dysfunction and Disulfidptosis Co-regulate Neuronal cell in Neuropathic Pain Based on Bioinformatics Analysis

Identification of potential crucial cuproptosis-related genes in myocardial ischemia-reperfusion injury through the bioinformatic analysis

Identification of immune characteristic biomarkers and therapeutic targets in cuproptosis for sepsis by integrated bioinformatics analysis and single-cell RNA sequencing analysis

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