A combined approach of differential scanning calorimetry and hot-stage microscopy with image analysis in the investigation of sulfathiazole polymorphism

Bakar, Mohd Rushdi Abu; Nagy, Zoltán K.; Rielly, Christopher D.

doi:10.1007/s10973-009-0001-z

Cited by 26 publications

(18 citation statements)

References 43 publications

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“…A combination of DSC and hot-stage microscopy with image analysis was used to investigate the polymorphism of sulfathiazole [51]. The results of the experiments proved that sulfathiazole tended to crystallize as mixtures of polymorphs, even though the literature methods for producing pure polymorph were followed.…”

Section: Analytical Applicationsmentioning

confidence: 99%

Vibrational spectroscopy used in polymorphic analysis

Bunaciu

Aboul‐Enein

Hoang

2015

TrAC Trends in Analytical Chemistry

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Section: Analytical Applicationsmentioning

confidence: 99%

Vibrational spectroscopy used in polymorphic analysis

Bunaciu

Aboul‐Enein

Hoang

2015

TrAC Trends in Analytical Chemistry

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“…Further information was obtained by PLTM, a good technique to follow polymorphic behaviour [49][50][51][52]. Polymorph I (crystals obtained in water at room temperature) and II (crystals obtained in ethanol at room temperature) were joined in the same microscopic field, and their thermal behaviour was observed, Fig.…”

Section: Solid Samples Obtained By Crystallization From Solutionsmentioning

confidence: 99%

Structural evidence of polymorphism and conformational isomorphism of a somewhat flexible molecule: m-anisic acid

Silva

Castro

Melro

et al. 2014

J Therm Anal Calorim

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m-Anisic acid is generally recognized as a safe (GRAS) flavouring substance. Its GRAS status and the functional groups present in the molecule make it an interesting candidate for pharmaceutical co-crystallization studies. The knowledge of m-anisic acid crystalline structure/ polymorphic behaviour is important information for its applications. In this work, a crystalline structure of m-anisic acid form I, T fus = 105°C, was solved by X-ray diffraction: monoclinic, space group P2 1 /n, with a = 13.8075 (5) Å , b = 5.0221(2) Å , c = 21.4455(8) Å , b = 99.325(3)°, Mr = 331.37, V = 1467.44(10) Å 3 , Z = 8 and R = 0.0395 (CCDC No. 985352). A recent paper by Raffo et al. (J Mol Struct 1070:86-93, 2014) (CCDC No. 985637) also resolved the structure, and within experimental error, the two structures are equal. The molecular flexibility of m-anisic acid results in the presence of two conformers in the unit cell, a rare case of conformational isomorphism. These two conformers were found by ab initio calculations to differ in energy by 4.9 kJ mol -1 . Solid samples were generated by crystallization from solutions and by melt cooling. Using a multidisciplinary approach involving thermal analysis (DSC, PLTM), infrared spectroscopy and X-ray powder diffraction, a new monotropic solid form II, T fus = 94°C, was identified and characterized. Polymorph II slowly transforms into polymorph I at room temperature.

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“…Crystal growth studies are often carried out by standard (optical) microscopy (Abu Bakar, Nagy, & Rielly, ; Berry, Seaton, Clegg, Harrington, Coles, Horton, … Blagden, ; Chieng, Rades, & Aaltonen, ). Other existing methods of crystal growth studies include sedimentation analysis, sensing zone methods, laser diffraction, light pulses, and image particle counters (John & Garside, ).…”

Section: Introductionmentioning

confidence: 99%

“…Crystal growth studies are often carried out by standard (optical) microscopy (Abu Bakar, Nagy, & Rielly, 2009;Berry, Seaton, Clegg, Harrington, Coles, Horton, . .…”

mentioning

confidence: 99%

A simple 2D composite image analysis technique for the crystal growth study of L‐ascorbic acid

Kumar

Lal

et al. 2017

Microscopy Res & Technique

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This work was destined for 2D crystal growth studies of L-ascorbic acid using the composite image analysis technique. Growth experiments on the L-ascorbic acid crystals were carried out by standard (optical) microscopy, laser diffraction analysis, and composite image analysis. For image analysis, the growth of L-ascorbic acid crystals was captured as digital 2D RGB images, which were then processed to composite images. After processing, the crystal boundaries emerged as white lines against the black (cancelled) background. The crystal boundaries were well differentiated by peaks in the intensity graphs generated for the composite images. The lengths of crystal boundaries measured from the intensity graphs of composite images were in good agreement (correlation coefficient "r" = 0.99) with the lengths measured by standard microscopy. On the contrary, the lengths measured by laser diffraction were poorly correlated with both techniques. Therefore, the composite image analysis can replace the standard microscopy technique for the crystal growth studies of L-ascorbic acid.

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A combined approach of differential scanning calorimetry and hot-stage microscopy with image analysis in the investigation of sulfathiazole polymorphism

Cited by 26 publications

References 43 publications

Vibrational spectroscopy used in polymorphic analysis

Vibrational spectroscopy used in polymorphic analysis

Structural evidence of polymorphism and conformational isomorphism of a somewhat flexible molecule: m-anisic acid

A simple 2D composite image analysis technique for the crystal growth study of L‐ascorbic acid

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