A combined experimental and in silico approach to determine the compatibility of poly(ester amide)s and indomethacin in polymer nanoparticles

Muljajew, Irina; Chi, Mingzhe; Vollrath, Antje; Weber, C.; Beringer-Siemers, Baerbel; Stumpf, Steffi; Hoeppener, Stephanie; Sierka, Marek; Schubert, Ulrich S.

doi:10.1016/j.eurpolymj.2021.110606

Cited by 10 publications

(2 citation statements)

References 48 publications

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“…Loading capacity (LC) in the present study was found lower than fungicide-loaded chitosan–carrageenan NEs, which may be due to higher ionic interactions between positively charged NH 4 + groups of chitosan and negatively charged OH − of carrageenan and, thus, higher EE and LC [ 35 ]. H-bonding between guar gum polymer-mancozeb enhanced the loading of mancozeb in nanocarrier [ 36 ].…”

Section: Resultsmentioning

confidence: 99%

Evaluation of Cytotoxicity, Release Behavior and Phytopathogens Control by Mancozeb-Loaded Guar Gum Nanoemulsions for Sustainable Agriculture

Kumar

Nehra

Kumar

et al. 2023

JoX

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Chemical fungicides are the backbone of modern agriculture, but an alternative formulation is necessary for sustainable crop production to address human health issues and soil/water environmental pollution. So, a green chemistry approach was used to form guar gum nanoemulsions (NEs) of 186.5–394.1 nm containing the chemical fungicide mancozeb and was characterized using various physio-chemical techniques. An 84.5% inhibition was shown by 1.5 mg/mL mancozeb-loaded NEs (GG-1.5) against A. alternata, comparable to commercial mancozeb (86.5 ± 0.7%). The highest mycelial inhibition was exhibited against S. lycopersici and S. sclerotiorum. In tomatoes and potatoes, NEs showed superior antifungal efficacy in pot conditions besides plant growth parameters (germination percentage, root/shoot ratio and dry biomass). About 98% of the commercial mancozeb was released in just two h, while only about 43% of mancozeb was released from nanoemulsions (0.5, 1.0 and 1.5) for the same time. The most significant results for cell viability were seen at 1.0 mg/mL concentration of treatment, where wide gaps in cell viability were observed for commercial mancozeb (21.67%) and NEs treatments (63.83–71.88%). Thus, this study may help to combat the soil and water pollution menace of harmful chemical pesticides besides protecting vegetable crops.

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Section: Resultsmentioning

confidence: 99%

Evaluation of Cytotoxicity, Release Behavior and Phytopathogens Control by Mancozeb-Loaded Guar Gum Nanoemulsions for Sustainable Agriculture

Kumar

Nehra

Kumar

et al. 2023

JoX

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“…6C ) were obtained. 126 The combined modelling and high throughput experimental approach may provide an opportunity to develop future nanoformulations in a more informed manner than the traditional screening methods typically used elsewhere; this combination of modelling may also accelerate the development of new formulations.…”

Section: Introductionmentioning

confidence: 99%

Nanomedicine strategies to improve therapeutic agents for the prevention and treatment of preterm birth and future directions

et al. 2023

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The step-wise dissolution method: An efficient DSC-based protocol for verification of predicted API–polymer compatibility

Mathers,

Pechar,

Hassouna

et al. 2023

International Journal of Pharmaceutics

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A combined experimental and in silico approach to determine the compatibility of poly(ester amide)s and indomethacin in polymer nanoparticles

Cited by 10 publications

References 48 publications

Evaluation of Cytotoxicity, Release Behavior and Phytopathogens Control by Mancozeb-Loaded Guar Gum Nanoemulsions for Sustainable Agriculture

Evaluation of Cytotoxicity, Release Behavior and Phytopathogens Control by Mancozeb-Loaded Guar Gum Nanoemulsions for Sustainable Agriculture

Nanomedicine strategies to improve therapeutic agents for the prevention and treatment of preterm birth and future directions

The step-wise dissolution method: An efficient DSC-based protocol for verification of predicted API–polymer compatibility

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