A combined laboratory and field evaluation of the Cholestech LDX and CardioChek PA point-of-care testing lipid and glucose analysers

Abstract

POCT has clear advantages for delivering NHS Health Checks over the laboratory-based approach although device performance does differ. Users should also be aware of the potential clinical governance and interference issues associated with these devices.

The impact of different point-of-care testing lipid analysers on cardiovascular disease risk assessment

“…Previously published POCT and laboratory TC and HDL-C measurements10 were used to calculate the TC/HDL-C ratios required by the CVD risk algorithms. When compared to the laboratory method, the LDX and CardioChek displayed mean (±SD) percentage biases of 9.7 (10)% (95% Limits of agreement (LOAs) −9.9% to 29.3%) and −3.7 (22.6)% (95% LOAs −48.8% to 41.4%) respectively (figure 1 and table 1).…”

“…POCT and laboratory TC and HDL-C data used to calculate the ratios were taken from ref. 10 HDL-C, high-density-lipoprotein cholesterol; TC, total cholesterol.…”

“…POCT and laboratory TC and HDL-C measurements were used to calculate the TC/HDL-C ratios required by the CVD risk algorithms. Interassay imprecision percentage coefficients of variation (%CV) for the laboratory, LDX and CardioChek TC and HDL-C methods during the course of the study were <3% (TC) and <5% (HDL-C), <4.1% (TC) and <5.2% (HDL-C)10 and <6.7% (TC) and <8.7% (HDL-C),10 respectively.…”

Percentiles of fasting serum insulin, glucose, HbA1c and HOMA-IR in pre-pubertal normal weight European children from the IDEFICS cohort

“…Precision and accuracy of this analyser were comparable to clinical diagnostic laboratory methods 23 with a slight positive bias of glucose measurement. 24 Pre-analytical sample processing of blood samples was done at the local survey centres or at local laboratories. Samples were then frozen (at − 80°C) and shipped to a central laboratory, certified by ISO 15189:2007, for later analysis of insulin, HbA1c and other biological markers.…”

Comparison of two point of care devices for capillary lipid screening in fasting and postprandial adults

“…Recent improvements in CardioChek analytical performance have been reported [1,2]. There are only a few peer-reviewed publications comparing the performance of the Cholestech and CardioChek devices to reference methods and these studies largely relied on samples from only fasting individuals, used only venous specimens, or did not evaluate all lipid values [3][4][5][6].…”