A combined marker of catatonia severity including autoimmune and thrombodynamic parameters in patients with autism spectrum disorder

Брусов, О. С.; Klyushnik, T P; Nv, Simashkova; Фактор, М. И.; Zozulya, S A; Никитина, С. Г.

doi:10.17116/jnevro202012007186

Cited by 1 publication

(2 citation statements)

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“…Education to increase clinician awareness of the need for screening for catatonia should improve recognition and more prompt intervention. About 20 percent of patients with catatonia do not show a positive response to lorazepam challenge, which can also lead to diagnostic delay ( 16 ). Such delay may contribute to more difficult-to-treat catatonia; experts emphasize early and rapid intervention with effective means ( 17 – 19 ).…”

Section: Discussionmentioning

confidence: 99%

“…Clinicians should consider catatonia in patients with ASD who display psychomotor changes, paying particular attention to regressed speech and functioning ( 16 , 22 , 23 ). Obtaining collateral information on baseline status and changes in level of functioning (including speech, written communication, aggression, ritualistic behaviors, and toileting), along with performing a catatonia screening tool, can provide crucial information leading to earlier diagnosis and optimal treatment ( 8 ).…”

Section: Discussionmentioning

confidence: 99%

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Excited Catatonia in Autism Spectrum Disorder: A Case Series

et al. 2021

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Introduction: Autistic catatonia is an under-recognized debilitating syndrome with long-lasting negative effects for families, healthcare workers, and high-cost to the healthcare system. In this report, we describe two cases of excited catatonia in young men diagnosed with autism. Both endured a delay to diagnosis and difficulty to obtain appropriate treatment.Main concern: Each patient had a change in behavior from their baseline but with differences in severity and onset. The diagnosis in the first patient was made after only 3 months as the change was dramatic and sudden. Yet, despite a confirmed diagnosis, it was difficult to treat as the importance of M-ECT was not recognized by the clinicians. The second patient had been suffering for more than 5 years with a slow progression of worsening aggressive symptoms. The aggression was so uncontrollable that the patient required sedation, intubation and daily ECT. Both suffered from agitation, unprovoked aggression, urinary incontinence, stereotypic, and OCD behaviors and compulsive masturbation.Primary Diagnosis, intervention/outcomes: Both patients were diagnosed with autism, one high-functioning, attending high school and working a part-time job, the second low-functioning, nearly non-verbal, isolated to home and ABA school. The first patient's diagnosis of catatonia was only suspected after five psychiatric admissions and more than 20 medication trials. Lorazepam challenge was effective, he was treated with a short series of ECT but each time the treatments were tapered, the aggression returned. Ultimately, stabilized on weekly ECT. The second patient's behavior was escalating over a 5 month period, to the point, the aggression was uncontrollable. He presented to the ED under involuntary hold and the behavior could not be stabilized to the point that emergent ECT was initiated.Conclusion: Two cases of autistic catatonia diagnosed and treated within a year time span at a small community hospital indicates that this diagnosis is more common than previously recognized. We propose screening all patients with neurodevelopmental disorders with the Bush-Francis and Kanner scales to diagnose and treat them appropriately.

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Section: Discussionmentioning

confidence: 99%