A combined measles, mumps, rubella and varicella vaccine (Priorix-Tetra™): Immunogenicity and safety profile

Czajka, Hanna; Schuster, Volker; Zepp, Fred; Esposito, Susanna; Douha, Martine; Willems, Paul

doi:10.1016/j.vaccine.2009.07.076

Cited by 63 publications

(42 citation statements)

References 44 publications

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“…Combining MMR and varicella into a single vaccine decreases pain for children and distress for parents, thus addressing common barriers to vaccine uptake, 6,[32][33][34] and may improve vaccine coverage levels and decrease immunization delivery costs. 35 These potential benefits must be balanced by the increased risk (albeit small) of febrile seizures with the combination vaccine.…”

Section: Resultsmentioning

confidence: 99%

“…For each vaccine administered, we compared the incidence of seizures in the 42-day "observation period" following administration (comparable with clinical trials of Priorix-Tetra and the postlicensure study of ProQuad 2,6,21 ) and the 7-to 10-day "peak period" (when previous studies have indicated that febrile seizure risk is expected to be highest 2,22 ) with the incidence in the 42 days preceding vaccination (control period) using a riskinterval analysis. 23 To confirm that the defined peak period was valid in our study, we conducted a sensitivity analysis, looking at 9 different risk windows ([5, 6, 7 days] × [10, 11, 12 days]).…”

Section: Discussionmentioning

confidence: 99%

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Risk of febrile seizures after first dose of measles–mumps–rubella–varicella vaccine: a population-based cohort study

MacDonald

Dover

Simmonds

et al. 2014

CMAJ

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Risk of febrile seizures after first dose of measles–mumps–rubella–varicella vaccine: a population-based cohort study

MacDonald

Dover

Simmonds

et al. 2014

CMAJ

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“…At present there was no effective treatment for varicella patients, antiviral and symptomatic treatment, Chinese medicine treatment were adopted to shorten the course of disease and prevent complications [5] . Although varicella was a self-limiting disease lasting about 2 weeks, the virus lurked in certain percentage of patients' dorsal root ganglia and brain nerve sensory ganglia after rehabilitation.…”

Section: Discussionmentioning

confidence: 99%

An investigation and analysis on the epidemic of varicella in a university of Weifang in China

Shao

Fang

et al. 2017

J. Appl. Virol.

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Objective To investigate the reasons of the cluster outbreak of varicella in university. Methods The cases were diagnosed by clinical manifestations and serological test. An epidemiological survey was carried out using case study questionnaire combined with serological test of close contacts. Results This outbreak lasted 45 days from Oct 15th to Nov 30th, four cases were accumulated involving one major and two classes, with the incidence rate of 3.7% (4/107). The serological test results showed that the VZV-IgM antibody was positive in acute phase sera of 4 patients, and the level of VZV-IgG antibody in the recovery phase sera was 4 times higher than that in the acute phase. One of 45 contacts was VZV-IgM positive while 4of 45 contacts were VZV-IgG positive. Conclusion This cluster varicella epidemic was caused by VZV. Close contact may be the risk factor.

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“…The measles vaccine contains Edmonston-Enders (Moraten) strain. The mumps vaccine contains Jeryl-Lynn strain, the rubella vaccine contains Wistar RA 27/3 strain, and the chickenpox vaccine contains Oka strain (11). Since the measles, mumps, and chickenpox vaccines are produced in chicken embryo fibroblast culture, they may contain trace amounts (picogram-nanogram) of egg proteins (ovalbumin) (12)(13)(14).…”

Section: Introductionmentioning

confidence: 99%

Measles, Measles-Mumps-Rubella, and Varicella Vaccinations in Children with Egg Allergy

Özdemir¹,

Ersavas²

2017

JAREM

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Objective: Egg allergy is the second most common food allergy in infants and may cause urticaria, angioedema, anaphylaxis, and exacerbation of atopic dermatitis. Egg allergy is diagnosed by carefully examining a patient's clinical history, performing contributory skin prick tests, and assessing specific IgE levels to hen's egg. The administration of measles, measles-mumps-rubella (MMR), and varicella vaccinations to children with egg allergy remains controversial. These vaccines contain trace amounts of egg proteins as they are produced in chicken embryo fibroblast cultures. The incidence of anaphylaxis as a result of vaccinations is very low, and its cause (egg or gelatin) is not well known. Here we report our experience with the three vaccinations in 18 patients with egg allergy (34 dose).Methods: Between 2013 and 2016, we retrospectively evaluated patients with egg allergy who presented to our allergy clinic for vaccinations. After performing the skin prick test for patients who were admitted to our clinic, vaccinations were administered by dividing the doses in equal two parts.Results: All patients had a clinical history, and atopic dermatitis coexisted with egg allergy in three patients. The skin prick test results were positive in 12 (67%) patients. The specific IgE test was positive in 16 (89%) patients. There was a reaction in just one (2.9%) patient of 18 patients of 34 dose vaccinations.Conclusion: Measles, MMR, and varicella vaccinations in children with egg allergy were found to be safe albeit small number of patients. We believe that egg allergy does not necessitate a delay or contraindication for vaccination.

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A combined measles, mumps, rubella and varicella vaccine (Priorix-Tetra™): Immunogenicity and safety profile

Cited by 63 publications

References 44 publications

Risk of febrile seizures after first dose of measles–mumps–rubella–varicella vaccine: a population-based cohort study

Risk of febrile seizures after first dose of measles–mumps–rubella–varicella vaccine: a population-based cohort study

An investigation and analysis on the epidemic of varicella in a university of Weifang in China

Measles, Measles-Mumps-Rubella, and Varicella Vaccinations in Children with Egg Allergy

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