A combined single-blind, double-blind, placebo-controlled study to determine the reproducibility of hypersensitivity reactions to aspartame

Garriga, Margarita M.; Berkebile, Carole; Metcalfe, Dean D.

doi:10.1016/0091-6749(91)90128-b

Cited by 42 publications

(11 citation statements)

References 11 publications

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“…The authors concluded that aspartame and its conversion products were no more likely than placebo to cause allergic symptoms in the subjects. These conclusions were further confirmed in a study by Garriga et al (1991). They also concluded that after a single blind and double blind placebo controlled food challenge (DBPCFC) with aspartame exposures up to 2000 mg none of the clinically evaluated and subsequently challenged subjects exhibited clear reproducible adverse reactions to aspartame.…”

Section: Discussionsupporting

confidence: 63%

Report of the meeting on Aspartame with National Experts

2010

EFSA Supporting Publications

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DISCLAIMER The present report is published complying with the transparency principle to which the European Food Safety Authority (EFSA) is subject. The conclusions and recommendations of this report reflect those of the national experts involved in the meetings 2The conclusions and recommendations of this report reflect those of the national experts involved in the meetings on aspartame and do not necessarily represent the views of EFSA. SUMMARYThe Advisory Forum of EFSA discussed the issue of aspartame in 2007 and at the 24th AF meeting held on 6-7 December 2007 it was agreed that a special meeting would be held on aspartame. This meeting of National Experts was to take place early in 2009 and, as provided in the Terms of Reference endorsed by the Advisory Forum, was to review the information available on aspartame; agree on the completeness of the information ensuring any missing data was added; identify possible data gaps and discrepancies in the available data and where such exist to consider detailed options to address the outstanding issues.An Organising Team, nominated by members of the Advisory Forum, was tasked with preparing for the meetings of National Experts by identifying, collating and reviewing all published papers on aspartame since the review carried out by the Scientific Committee on Food in 2002. In addition the Organising Team also considered available non-peer reviewed information and anecdotal claims by individuals who attributed various symptoms and illnesses directly to aspartame consumption. A meeting was held with interested parties who had submitted information in response to a ‗call for data' published by EFSA in September, 2008.Each of the areas considered, including exposure data, brain function, satiation and appetite, allergenicity and immunotoxicity, metabolic aspects and diabetes, carcinogenicity (including cancer epidemiology) and genotoxicity were considered by the Organising Team and reported on. For each, consistent with the Terms of Reference for the National Expert Meeting, they made preliminary conclusions on whether there were data gaps or discrepancies which required further consideration. This report represents the results of these deliberations.Overall, the Organising Team did not identify any major gaps in information on aspartame and the National Experts agreed with their view. However, several suggestions are made within this report for additional data which would add to the available knowledge on aspartame and its metabolites. To address the communications element of the Terms of Reference a workshop with stakeholders and other interested parties is to be arranged to share and discuss the findings of the work.In conclusion, the National Experts have not identified any new evidence that requires a recommendation to EFSA that the previous Opinions of EFSA and the SCF need to be reconsidered. 3The conclusions and recommendations of this report reflect those of the national experts involved in the meetings on aspartame and do not necessarily represent the views of EF...

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Section: Discussionsupporting

confidence: 63%

Report of the meeting on Aspartame with National Experts

2010

EFSA Supporting Publications

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“…Aspartame has also shown not to cause allergic reaction in adults when compared to placebo in randomized, double-blinded studies administering aspartame doses at one time point [24], [25]. A number of smaller studies have shown improvement in dermatitis with aspartame avoidance [22], [23], [41].…”

Section: Discussionmentioning

confidence: 99%

“…However, the authors could not explain the origin or meaning of this effect. Other studies have shown improvements in dermatitis with aspartame avoidance [22], [23], while yet others found no elicit allergic reactions [24], [25]. This suggests that improvement in dermatitis is most likely a relatively rare side effect of aspartame avoidance.…”

Section: Introductionmentioning

confidence: 94%

Consumption of Artificially-Sweetened Soft Drinks in Pregnancy and Risk of Child Asthma and Allergic Rhinitis

et al. 2013

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BackgroundPast evidence has suggested a role of artificial sweeteners in allergic disease; yet, the evidence has been inconsistent and unclear.ObjectiveTo examine relation of intake of artificially-sweetened beverages during pregnancy with child asthma and allergic rhinitis at 18 months and 7 years.MethodsWe analyzed data from 60,466 women enrolled during pregnancy in the prospective longitudinal Danish National Birth Cohort between 1996 and 2003. At the 25th week of gestation we administered a validated Food Frequency Questionnaire which asked in detail about intake of artificially-sweetened soft drinks. At 18 months, we evaluated child asthma using interview data. We also assessed asthma and allergic rhinitis through a questionnaire at age 7 and by using national registries. Current asthma was defined as self-reported asthma diagnosis and wheeze in the past 12 months. We examined the relation between intake of artificially-sweetened soft drinks and child allergic disease outcomes and present here odds ratios with 95% CI comparing daily vs. no intake.ResultsAt 18 months, we found that mothers who consumed more artificially-sweetened non-carbonated soft drinks were 1.23 (95% CI: 1.13, 1.33) times more likely to report a child asthma diagnosis compared to non-consumers. Similar results were found for child wheeze. Consumers of artificially-sweetened carbonated drinks were more likely to have a child asthma diagnosis in the patient (1.30, 95% CI: 1.01, 1.66) and medication (1.13, 95% CI: 0.98, 1.29) registry, as well as self-reported allergic rhinitis (1.31, 95% CI: 0.98, 1.74) during the first 7 years of follow-up. We found no associations for sugar-sweetened soft drinks.ConclusionCarbonated artificially-sweetened soft drinks were associated with registry-based asthma and self-reported allergic rhinitis, while early childhood outcomes were related to non-carbonated soft drinks. These results suggest that consumption of artificially-sweetened soft drinks during pregnancy may play a role in offspring allergic disease development.

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“…Aspartame Aspartame (NutraSweet; Chicago, IL), a dipeptide of aspartic acid in phenylalanine, is a low-calorie artificial sweetener 180 times sweeter than sucrose [28]. Two cases of aspartame-induced urticaria, confirmed by placebo-controlled, double-blind challenge have been reported [30] , and additional cases by the same author have also been described [31]; however, other investigators have encountered difficulty recruiting subjects with adverse reactions to aspartame and have found that such subjects do not have reproducible reactions [32,33]. Two cases of aspartame-induced urticaria, confirmed by placebo-controlled, double-blind challenge have been reported [30] , and additional cases by the same author have also been described [31]; however, other investigators have encountered difficulty recruiting subjects with adverse reactions to aspartame and have found that such subjects do not have reproducible reactions [32,33].…”

Section: Monosodium Glutamatementioning

confidence: 99%

Adverse reactions to food additives

Simon

2003

Curr Allergy Asthma Rep

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There are thousands of additives used by the food industry for a variety of purposes in the foods we eat. However, only a small number have been implicated in causing adverse reactions in humans. Although there are reported cases of individuals who have reactions to single additives, most of the medical literature involves patients with asthma or chronic idiopathic urticaria/angioedema whose conditions are exacerbated after ingestion of food additives. Many of these reports are characterized by poorly controlled challenge procedures. Recent studies performed under properly controlled conditions imply that sensitivity to food additives in patients with chronic urticaria/angioedema is very uncommon.

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A combined single-blind, double-blind, placebo-controlled study to determine the reproducibility of hypersensitivity reactions to aspartame

Cited by 42 publications

References 11 publications

Report of the meeting on Aspartame with National Experts

Report of the meeting on Aspartame with National Experts

Consumption of Artificially-Sweetened Soft Drinks in Pregnancy and Risk of Child Asthma and Allergic Rhinitis

Adverse reactions to food additives

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