A combined spectroscopic and quantum chemical approach to study the molecular interaction between anti-inflammatory drug Hydrocortisone and amino acid l-Phenylalanine

Aqueous solution and solid-state behaviour of l-homophenylalanine: experiment, modelling, and DFT calculations

“…where k ij , in eqn (7), is the dispersion energy correction parameter. In this work, this potentially temperature dependent parameter is modelled as follows:…”

“…2 Different methods e.g. based on gravimetry, [3][4][5][6] spectroscopy, 6,7 titration, 8 laser techniques, 9 Differential Scanning Calorimetry (DSC), 10,11 refractive index, 12,13 or HPLC 14,15 can then be applied as analytical techniques. Some of these methods have been in use for decades indicating their reliability.…”

Solubility Determination and Thermodynamic Modeling of L-Phenylalanine in 12 Monosolvents from 283.15 to 323.15 K

“…L -Phenylalanine (Figure , C 9 H 11 NO 2 , CAS Registry Number: 63–91–2), one of the essential amino acids, is an important intermediate for the synthesis of many biological chemicals and has been widely used in the food, pharmaceutical, and chemical industries, notably in the production of aspartame (one of the most popular sweeteners) and several drugs with antivirus and anticancer properties. , It is a precursor of tyrosine in melanin synthesis and helps in the production of melanin, which gives color to the skin, hair, and eyes. − In addition, L -phenylalanine can reduce oxidative stress and restrict melanocyte degeneration due to its antioxidant property …”

“…3−5 In addition, Lphenylalanine can reduce oxidative stress and restrict melanocyte degeneration due to its antioxidant property. 5 Crystallization is not only in general the last chemical purification step in the production of active pharmaceutical ingredients (APIs) but also an effective means to control the quality of APIs in terms of crystal form, shape, size distribution, bulk and tap density, etc., which have the potential to impact its bioperformance. 6 The fundamental solubility data are generally considered an essential factor in the design of crystallization processes as well as an important thermodynamic property in the investigation of solvent effects.…”