2000
DOI: 10.1016/s0278-6915(99)00119-2
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A combined subchronic (90-day) toxicity and neurotoxicity study of a single-cell source of docosahexaenoic acid triglyceride (DHASCO® oil)

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Cited by 37 publications
(18 citation statements)
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“…2 and 3) and elevated plus maze tests (Table V) all groups present the same behavior, showing that FO supplementation has no effect on this behaviors. Other studies found the same result, which corroborate our data (Wainwright et al, 1994;Wainright et al, 1999;Arterburn et al, 2000;Carrié et al, 2000;Wilde et al, 2002). These behavior tests were important because they give support to suggest that the results shown in forced swimming test were caused by FO effect upon CNS.…”
Section: Discussionsupporting
confidence: 92%
“…2 and 3) and elevated plus maze tests (Table V) all groups present the same behavior, showing that FO supplementation has no effect on this behaviors. Other studies found the same result, which corroborate our data (Wainwright et al, 1994;Wainright et al, 1999;Arterburn et al, 2000;Carrié et al, 2000;Wilde et al, 2002). These behavior tests were important because they give support to suggest that the results shown in forced swimming test were caused by FO effect upon CNS.…”
Section: Discussionsupporting
confidence: 92%
“…These results corroborate earlier findings from a 28-day SpragueDawley rat study with algal-DHA [35]. The retroconversion of DHA to EPA is also observed in other tissues such as heart and liver [36]. In humans receiving 280 mg of DHA, a retroconversion rate of *1.4% has been reported [34], but rates as high as 12% have also been noted in subjects who received 1.62 g DHA [37,38].…”
Section: Discussionsupporting
confidence: 89%
“…Higher doses are needed to account for increased metabolic rates in small animals; they may also shed light on any issues with toxicity. The safety of DHA, as contained in algal-DHA, has been evaluated in several animal studies [36,[39][40][41][42][43][44]. These studies included tests for genetic, acute, subchronic, and developmental toxicity.…”
Section: Discussionmentioning
confidence: 99%
“…Dietary DHA was in the form of microalgae-derived DHASCO® oil (Martek, Columbia, MD), and was mixed into the diet during manufacturing. A previous study of DHASCO® oil consumption in rats revealed no adverse outcomes at doses exceeding those used in the present study [24]. Further, dietary DHA content was lower than that used in some studies of DHA and cardiovascular outcomes[25] and similar to that used in others [26].…”
Section: Methodssupporting
confidence: 43%