A combined wireless neural stimulating and recording system for study of pain processing

Ativanichayaphong, Thermpon; He, Ji; Hagains, Christopher E.; Peng, Yuan Bo; Chiao, J.-C.

doi:10.1016/j.jneumeth.2007.12.014

Cited by 44 publications

(31 citation statements)

References 19 publications

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“…The spinal cord was immobilized in a stereotaxic frame and covered with mineral oil. The end tidal was maintained at around 30 mmHg and the body temperature was maintained at 37 using a feedback controlled heating pad and a rectal thermal sensor probe [40].…”

Section: Animal Experimentsmentioning

confidence: 99%

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An Integrated Flexible Implantable Micro-Probe for Sensing Neurotransmitters

Cao

Nguyen

et al. 2012

IEEE Sensors J.

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In this work, we have developed an integrated flexible implantable probe on a polyimide-film substrate for sensing neurotransmitters. The flexibility of the probe helps to prevent scar forming in tissues aiming for long-term in vivo monitoring. A micro Ag/AgCl reference electrode was integrated in the same probe with the Au/Cr or Pt/Cr working electrodes providing measurements without the need of a separate reference probe. Several electrode configurations have been considered and designed for implantation at various locations in the central nervous system. The prototype device for proof of principle was an enzyme-based electrochemical L-glutamate sensor using L-glutamate oxidase. A comparison between Au and Pt thin films was conducted by cyclic voltammetry to evaluate their performance as working electrodes. The L-glutamate oxidase was deposited on the working electrodes followed by a meta-Phenylenediamine electropolymerization process to improve the selectivity. The self-referencing technique was also utilized to enhance both the limit of detection and selectivity. The assembled sensors were calibrated and tested at various concentrations of L-glutamate with and without the presence of interfering molecules. The results showed good sensitivity and selectivity. In vivo animal tests were conducted to show the capability of detecting changes of electrochemical signals responding to graded peripheral somatosensory stimuli.

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Section: Animal Experimentsmentioning

confidence: 99%

“…The pressure stimulus was between innocuous and noxious. The poke stimulus was applied by a sharp needle as a noxious one [40]. Fig.…”

Section: Animal Experimentsmentioning

confidence: 99%

An Integrated Flexible Implantable Micro-Probe for Sensing Neurotransmitters

Cao

Nguyen

et al. 2012

IEEE Sensors J.

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“…The high-pass filter eliminates low frequency components in signals generated by the patient's movement. More details about the design of the front-end were described by Ativanichayaphong et al 1 The back-end receives signals and feeds them to a commercial (Cadwell Cascade TM ) IONM system. The back-end is composed of a 914 MHz receiver module (RX3A, Radiometrix, Ltd.) and an attenuator.…”

Section: Wireless System For Tcmep Acquisitionmentioning

confidence: 99%

A Wireless System for Monitoring Transcranial Motor Evoked Potentials

et al. 2010

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Intraoperative neurophysiological monitoring (IONM) is commonly used as an attempt to minimize neurological morbidity from operative manipulations. The goal of IONM is to identify changes in the central and peripheral nervous system function prior to irreversible damage. Intraoperative monitoring also has been effective in localizing anatomical structures, including peripheral nerves and sensorimotor cortex, which helps guide the surgeon during dissection. As part of IONM, transcranial motor evoked potentials (TcMEPs), and somatosensory evoked potentials (SSEPs) are routinely monitored. However, current wired systems are cumbersome as the wires contribute to the crowded conditions in the operating room and in doing so not only it limits the maneuverability of the surgeon and assistants, but also places certain demand in the total anesthesia required during surgery, due to setup preoperative time needed for proper electrode placement, due to the number and length of the wires, and critical identification of the lead wires needed for stimulation and recording. To address these limitations, we have developed a wireless TcMEP IONM system as a first step toward a multimodality IONM system. Bench-top and animal experiments in rodents demonstrated that the wireless method reproduced with high fidelity, and even increased the frequency bandwidth of the TcMEP signals, compared to wired systems. This wireless system will reduce the preoperative time required for IONM setup, add convenience for surgical staff, and reduce wire-related risks for patients during the operation.

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“…The single unit APs fired by the neurons were analyzed in Spike2 software and the firing rates were used as the indication of neuronal activities. For neural stimulating and recording, we utilized our hybrid wireless system that was demonstrated in [16]. Results showed that the VPL can be used as the signal in our closedloop system to distinguish between non-noxious stimuli (brush) and noxious stimuli (pinch).…”

Section: Introductionmentioning

confidence: 99%

Modulation of the mechano-nociceptive neural activities in the ventral posterolateral nucleus in thalamus

Farajidavar

Hagains²,

Peng³

et al. 2013

2013 6th International IEEE/EMBS Conference on Neural Engineering (NER)

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Deep brain stimulation (DBS) of the periaqueductal gray (PAG) has been shown to be an option for chronic pain inhibition. Drawbacks exist due to electrical stimulation doses given in an open-loop and manual fashion based on patients' subjective feedback. In response, we have developed a closed-loop system capable of detecting nociceptive signals from the spinal cord while delivering electrical stimulation to the PAG based on the recorded signals. However, such a system is difficult to be utilized on freely moving small animals since spine movement displaces electrodes during recording. Therefore, we aim to find the reference signals within the brain as the probe movement may be able to be minimized. In this study, we recorded single-unit action potentials (APs) from the ventral posterior lateral (VPL) nucleus of the thalamus in response to graded mechanical stimuli (brush, pressure and pinch). Results obtained from forty neurons showed that the mean rate of the action potentials during pinch was significantly higher in compare to that during brush while no significant difference was found between the pressure with the other two stimuli. Experiments also show that DBS delivered to the PAG could significantly decrease the neural activities in the VPL.

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A combined wireless neural stimulating and recording system for study of pain processing

Cited by 44 publications

References 19 publications

An Integrated Flexible Implantable Micro-Probe for Sensing Neurotransmitters

An Integrated Flexible Implantable Micro-Probe for Sensing Neurotransmitters

A Wireless System for Monitoring Transcranial Motor Evoked Potentials

Modulation of the mechano-nociceptive neural activities in the ventral posterolateral nucleus in thalamus

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