A Common Mucosal Chemokine (Mucosae-Associated Epithelial Chemokine/CCL28) Selectively Attracts IgA Plasmablasts

Lazarus, Nicole H.; Kunkel, Eric J.; Johnston, Brent; Wilson, Eric; Youngman, Kenneth R.; Butcher, Eugene C.

doi:10.4049/jimmunol.170.7.3799

Cited by 222 publications

(219 citation statements)

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“…We have indeed demonstrated that a substantial fraction of plasma cells derived from human bone marrow expresses CCR10 and efficiently migrates to its ligands CCL27 and CCL28 (25). Furthermore, Butcher and his colleagues (26,27) have demonstrated that IgA-ASCs present in various mucosal tissues commonly express CCR10. We have also demonstrated that CCR10 plays an important role in the homing of IgA-ASCs into the small intestine and colon (11).…”

Section: -Dihydroxyvitamin D 3 Induces Ccr10 Expression In Terminmentioning

confidence: 92%

“…It is known that IgA-ASCs in the intestinal tissues frequently express CCR9 and/or CCR10 (26,27). Recently, Mora et al (39) have demonstrated that DCs in the gut-associated lymphoid tissues (GALT), but not those in the nonmucosal lymphoid tissues, induce the expression of ␣ 4 ␤ 7 and CCR9 in activated B cells.…”

Section: Discussionmentioning

confidence: 99%

“…In the B cell lineage, CCR10 is considered to play an essential role in the common mucosal immune system by guiding IgA-ASCs to various mucosal tissues via its ligand CCL28, which is constitutively expressed by epithelial cells in various mucosal tissues (2,11,(25)(26)(27). In the present study, by using IL-21-induced terminal differentiation of human B cells in vitro (36), we have demonstrated that 1,25-(OH) 2 D 3 robustly induces CCR10 expression in terminally differentiating human B cells (Fig.…”

Section: Discussionmentioning

confidence: 99%

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1,25-Dihydroxyvitamin D3 Induces CCR10 Expression in Terminally Differentiating Human B Cells

Shirakawa

Nagakubo

Hieshima

et al. 2008

The Journal of Immunology

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In the B cell lineage, CCR10 is known to be selectively expressed by plasma cells, especially those secreting IgA. In this study, we examined the regulation of CCR10 expression in terminally differentiating human B cells. As reported previously, IL-21 efficiently induced the differentiation of activated human CD19+ B cells into IgD−CD38+ plasma cells in vitro. A minor proportion of the resulting CD19+IgD−CD38+ cells expressed CCR10 at low levels. 1,25-Dihydroxyvitamin D3 (1,25-(OH)2D3), the active metabolite of vitamine D3, dramatically increased the proportion of CD19+IgD−CD38+ cells expressing high levels of CCR10. The 1,25-(OH)2D3 also increased the number of CCR10+ cells expressing surface IgA, although the majority of CCR10+ cells remained negative for surface IgA. Thus, 1,25-(OH)2D3 alone may not be sufficient for the induction of IgA expression in terminally differentiating human B cells. To further determine whether 1,25-(OH)2D3 directly induces CCR10 expression in terminally differentiating B cells, we next performed the analysis on the human CCR10 promoter. We identified a proximal Ets-1 site and an upstream potential vitamin D response element to be critical for the inducible expression of CCR10 by 1,25-(OH)2D3. We confirmed the specific binding of Ets-1 and 1,25-(OH)2D3-activated vitamin D receptor to the respective sites. In conclusion, 1,25-(OH)2D3 efficiently induces CCR10 expression in terminally differentiating human B cells in vitro. Furthermore, the human CCR10 promoter is cooperatively activated by Ets-1 and vitamin D receptor in the presence of 1,25-(OH)2D3.

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Section: -Dihydroxyvitamin D 3 Induces Ccr10 Expression In Terminmentioning

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

1,25-Dihydroxyvitamin D3 Induces CCR10 Expression in Terminally Differentiating Human B Cells

Shirakawa

Nagakubo

Hieshima

et al. 2008

The Journal of Immunology

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“…Liver lymphocytes were obtained by mincing the tissue, mechanically dispersing it through a wire mesh, and isolating the lymphocytes on a 33% Percoll (GE Healthcare Bio-Sciences) gradient. Lung lymphocytes were isolated by digesting lungs in 300 U/ml type VIII collagenase (Sigma-Aldrich) for 30 min as described previously (54). Lymphocytes were resuspended in RPMI 1640 with 10% FCS and allowed to recover in a CO 2 incubator for Ͼ1 h before chemotaxis experiments.…”

Section: Cell Isolationmentioning

confidence: 99%

Critical Role for the Chemokine Receptor CXCR6 in Homeostasis and Activation of CD1d-Restricted NKT Cells

Germanov¹,

Veinotte²,

Cullen³

et al. 2008

The Journal of Immunology

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105

109

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NK T (NKT) cells play important roles in the regulation of diverse immune responses. However, little is known about the mechanisms that regulate homeostasis and activation of these cells. Thymic NKT cells up-regulated the chemokine receptor CXCR6 following positive selection and migrated toward CXCL16 in vitro. However, CXCR6 was not essential for thymic development or maturation. In contrast, liver and lung NKT cells were depleted in CXCR6+/− and CXCR6−/− mice. The reduction in liver and lung NKT cells coincided with an increase in bone marrow NKT cells, suggesting a redistribution of NKT cells in CXCR6−/− animals. In wild-type mice, CXCL16 neutralization reduced accumulation of mature NK1.1+, but not immature NK1.1− NKT cell recent thymic emigrants in the liver. Given that thymic NKT cells are preferentially exported as NK1.1− cells, this suggests an additional role for CXCR6/CXCL16 in maturation or survival of immature liver NKT cells. CXCL16 blockade did not deplete resident NK1.1+ NKT cells, indicating that CXCR6/CXCL16 are not required to retain mature NKT cells in the liver. Cytokine production by liver and spleen NKT cells was impaired in CXCR6−/− mice following in vivo stimulation with α-galactosylceramide, implicating a novel role for CXCR6 in NKT cell activation. Reduced IFN-γ production was not due to an intrinsic defect as production was normal following PMA and ionomycin stimulation. Preformed transcripts for IL-4, but not IFN-γ, were reduced in CXCR6−/− liver NKT cells. These data identify critical roles for CXCR6/CXCL16 in NKT cell activation and the regulation of NKT cell homeostasis.

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“…For example, in mice only DC derived from Peyer's patches and mesenteric lymph nodes were able to induce expression of α 4 β 7 + and CCR9 + on CD8 + T cells leading to site specific homing of these effector cells to the small intestinal lamina propria [74,109]. CCR9, the receptor for the thymus-expressed chemokine (TECK, CCL 25), is expressed on effector B and T cells and mediates the selective migration of these effector cells to the small intestine in humans and mice [19,87,120]. Interestingly, CCR9 -/-knockout mice display reduced numbers of plasma cells in the small intestinal lamina propria and impaired ability to respond to oral vaccination [119].…”

Section: General Considerations For Mucosal Vaccinesmentioning

confidence: 99%

Mucosal delivery of vaccines in domestic animals

et al. 2006

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-Mucosal vaccination is proving to be one of the greatest challenges in modern vaccine development. Although highly beneficial for achieving protective immunity, the induction of mucosal immunity, especially in the gastro-intestinal tract, still remains a difficult task. As a result, only very few mucosal vaccines are commercially available for domestic animals. Here, we critically review various strategies for mucosal delivery of vaccines in domestic animals. This includes live bacterial and viral vectors, particulate delivery-systems such as polymers, alginate, polyphosphazenes, immune stimulating complex and liposomes, and receptor mediated-targeting strategies to the mucosal tissues. The most commonly used routes of immunization, strategies for delivering the antigen to the mucosal surfaces, and future prospects in the development of mucosal vaccines are discussed. mucosal / vaccine / livestock / animals / review

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A Common Mucosal Chemokine (Mucosae-Associated Epithelial Chemokine/CCL28) Selectively Attracts IgA Plasmablasts

Cited by 222 publications

References 29 publications

1,25-Dihydroxyvitamin D3 Induces CCR10 Expression in Terminally Differentiating Human B Cells

1,25-Dihydroxyvitamin D3 Induces CCR10 Expression in Terminally Differentiating Human B Cells

Critical Role for the Chemokine Receptor CXCR6 in Homeostasis and Activation of CD1d-Restricted NKT Cells

Mucosal delivery of vaccines in domestic animals

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