A Common Polymorphism in the Complement Factor H Gene Is Associated With Increased Risk of Myocardial Infarction

Kardys, Isabella; Klaver, Caroline C.W.; Despriet, Dominiek D. G.; Bergen, Arthur A. B.; Uitterlinden, André G.; Hofman, Albert; Oostra, Ben A.; Duijn, Cornelia M. van; Jong, Paulus T. V. M. de; Witteman, Jacqueline C. M.

doi:10.1016/j.jacc.2005.11.076

Cited by 85 publications

(64 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Factor H is a complement regulator, and polymorphisms, especially Y402H, in the Factor H-gene is extensively studied and associated with age-related macular degeneration (Gehrs et al, 2010). There are conflicting results about the Y402H polymorphisms and cardiovascular disease including myocardial infarction, but most studies find no association, so the importance of factor H variants in cardiovascular disease at present is unclear (Zee et al, 2006;Kardys et al, 2006;Nicaud et al, 2007;Stark et al, 2007;Sofat et al, 2010). Thus, some variants in genes encoding proteins of the complement system including MBL and C3 are associated with risk for coronary heart disease, while in others like factor H appear to be more uncertain.…”

Section: Genetic Studies On the Complement System And Risk Of Coronarmentioning

confidence: 99%

A vital role for complement in heart disease

Lappegård

Garred

Jonasson

et al. 2014

Molecular Immunology

View full text Add to dashboard Cite

Heart diseases are common and significant contributors to worldwide mortality and morbidity. During recent years complement mediated inflammation has been shown to be an important player in a variety of heart diseases. Despite some negative results from clinical trials using complement inhibitors, emerging evidence points to an association between the complement system and heart diseases. Thus, complement seems to be important in coronary heart disease as well as in heart failure, where several studies underscore the prognostic importance of complement activation. Furthermore, patients with atrial fibrillation often share risk factors both with coronary heart disease and heart failure, and there is some evidence implicating complement activation in atrial fibrillation. Moreover, Chagas heart disease, a protozoal infection, is an important cause of heart failure in Latin America, and the complement system is crucial for the protozoa-host interaction. Thus, complement activation appears to be involved in the pathophysiology of a diverse range of cardiac conditions. Determination of the exact role of complement in the various heart diseases will hopefully help to identify patients that might benefit from therapeutic complement intervention.

show abstract

Section: Genetic Studies On the Complement System And Risk Of Coronarmentioning

confidence: 99%

A vital role for complement in heart disease

Lappegård

Garred

Jonasson

et al. 2014

Molecular Immunology

View full text Add to dashboard Cite

show abstract

“…18 Participants were genotyped for the complement factor H (CFH) Y402H polymorphism in genomic DNA with an allelic discrimination assay (TaqMan; Applied Biosystems, Foster City, CA). 19 Apolipoprotein E (APOE) genotype was determined on DNA samples using a polymerase chain reaction followed by enzymatic digestion. 20 …”

Section: Other Measurementsmentioning

confidence: 99%

Age-Related Macular Degeneration and the Risk of Stroke

Wieberdink

Ikram

et al. 2011

Stroke

Self Cite

View full text Add to dashboard Cite

Background and Purpose-Age-related macular degeneration (AMD) and stroke are both frequent diseases in the elderly.A link between AMD and stroke has been suggested, because both disorders have many risk factors in common. The aim of this study was to investigate the association between AMD and stroke and the subtypes cerebral infarction and intracerebral hemorrhage in the general elderly population. Methods-This study was part of the population-based Rotterdam Study and included 6207 participants aged Ն55 years who were stroke-free at baseline (1990 to 1993). Signs of AMD were assessed on fundus photographs at baseline and at regular follow-up examinations and were categorized in 5 stages (0 to 4) representing an increasing severity. Late AMD (Stage 4) was subdivided into dry and wet AMD. Follow-up for incident stroke was complete up to January 1, 2007. Data were analyzed using time-dependent Cox regression models adjusted for age, sex, and potential confounders. Results-During a median follow-up of 13.6 years, 726 participants developed a stroke (397 cerebral infarction, 59intracerebral hemorrhage, 270 unspecified). Late AMD was associated with an increased risk of any stroke (hazard ratio, 1.56; 95% CI, 1.08 to 2.26) due to a strong association with intracerebral hemorrhage (hazard ratio, 6.11; 95% CI, 2.34 to 15.98). In contrast, late AMD was not associated with cerebral infarction. Earlier AMD stages were not associated with risk of stroke or any of its subtypes. Conclusions-We found that late AMD is strongly associated with intracerebral hemorrhage, but not with cerebral infarction, in the general elderly population. (Stroke. 2011;42:2138-2142.)

show abstract

“…Recientemente, se han publicado algunos trabajos analizando la asociación entre el polimorfismo rs1410996 del gen CFH y la cardiopatía isquémica. En un estudio prospectivo realizado en una población general mayor de 55 años se encontró una asociación importante entre el estado homocigoto y el riesgo de infarto de miocardio 16 . Esta asociación aumentaba significativamente con la presencia de otros factores de riesgo cardiovascular como el tabaco, la hipercolesterolemia y la diabetes tipo 2.…”

Section: Discussionunclassified

“…Además, ambas entidades comparten mecanismos fisiopatológicos como la generación de especies reactantes de oxígeno en respuesta a productos finales de la glicosilación avanzada, la inflamación y la activación de la vía alternativa del complemento 15 . En relación a estos polimorfismos es interesante subrayar la posible asociación que pueden tener los polimorfismos del gen CFH en el infarto de miocardio 16 . El objetivo principal de este trabajo es valorar si los polimorfismos CFH: rs1410996 y ARMS2: rs10490924 están asociados con el desarrollo de la retinopatía diabética proliferativa y el CFH: rs1410996, además, con el infarto de miocardio.…”

unclassified

Papel de los polimorfismos de los genes CFH y ARMS2 en el desarrollo de la retinopatía y la cardiopatía isquémica en la diabetes tipo 1

Toni

Hermida²,

Toledo³

et al. 2012

Anales Sis San Navarra

View full text Add to dashboard Cite

artículos originales0Papel de los polimorfismos de los genes cFH y arMs2 en el desarrollo de la retinopatía y la cardiopatía isquémica en la diabetes tipo 1 Fundamento. La diabetes tipo 1 (DT1) es un enfermedad con elevada morbilidad vascular. El objetivo de este estudio es valorar la asociación de los polimorfismos rs1410996 del gen CFH y rs10490924 del gen ARMS2 en pacientes con DT1.Material y métodos. Se trata de un estudio retrospectivo, en el que se han analizado las características clínicas y los polimorfismos rs1410996 del gen CFH y rs10490924 del gen ARMS2 de 147 pacientes con DT1 valorados en la consulta de Endocrinología.resultados. Todos los pacientes que desarrollaron retinopatía diabética proliferativa en los primeros 20 años de evolución eran portadores del polimorfismo rs1410996 del gen CFH. La frecuencia del alelo de riesgo fue significativamente mayor en los pacientes con cardiopatía isquémica que en los que no la presentaban (75 frente a 53%, p<0,001).conclusiones. Parece existir una tendencia a aumentar el riesgo de desarrollar retinopatía diabética proliferativa en los pacientes con DT1 asociado con el polimorfismo rs1410996 del gen CFH. Este polimorfismo parece asociarse también con el desarrollo de cardiopatía isquémica en estos pacientes. Sin embargo, el polimorfismo rs10490924 del gen ARMS2 no parece asociarse con la retinopatía ni con la cardiopatía isquémica.Palabras clave. Diabetes tipo 1. Retinopatía diabética proliferativa. Cardiopatía isquémica. CFH. ARMS2. aBstractBackground. Type 1 diabetes is associated with vascular morbidity. The aim of this study was to evaluate the role of polymorphisms rs1410996 CFH and rs10490924 ARMS2 with proliferative diabetic retinopathy and coronary disease in type 1 diabetes patients. Material and methods.We present a retrospective study that analyses the clinical characteristics and the polymorphisms rs1410996 CFH and rs10490924 ARMS2 of 147 type 1 diabetes patients.

show abstract

A Common Polymorphism in the Complement Factor H Gene Is Associated With Increased Risk of Myocardial Infarction

Abstract: Our data suggest that the CFH gene determines susceptibility to myocardial infarction. This finding underscores the importance of the alternative complement system in cardiovascular disease.

Cited by 85 publications

References 25 publications

A vital role for complement in heart disease

A vital role for complement in heart disease

Age-Related Macular Degeneration and the Risk of Stroke

Papel de los polimorfismos de los genes CFH y ARMS2 en el desarrollo de la retinopatía y la cardiopatía isquémica en la diabetes tipo 1

Contact Info

Product

Resources

About