This study aimed to describe the meaning of ?self-care? from the perspectives of older persons living with diabetes and explored the self-care behaviors of older persons living with diabetes. The qualitative method was applied in this study. Data were collected by in-depth interview of 16 older persons with Type 2 diabetes in Vietnam. In addition, field note and observation note were written on the reflections, ideas, and meaning of self-care and self-care practices during the data collection process. All data were analyzed by using content analysis method. The results of the study were reflected the self-care from the perspective of older people with type 2 diabetes. The informants in this study stated the meaning of the disease as diabetes is a disease of ?sugar pee?; and diabetes is the ?lifelong? and ?forever? disease. The first objective in this study is that ?Meaning self-care? which including 2 themes 1) Self-responsibility to take care of self for the lifelong, and 2) Seeking information to take good care of self. And the second objective is ?Self-care practices? with including 7 themes: 1) Self-monitoring of blood sugar level, 2) Taking diabetes medication regularly, 3) Control eating but it is difficult, 4) Doing some physical activities to get sweat, 5) Caring for their foot, 6) Living with the disease, 7) Taking home remedies. This qualitative research methodology expands the understanding of the context in which finding the meaning of self-care, diabetes self- care occurred and how they used to manage their diabetes. Developing interventions for Vietnamese older persons with diabetes could help them to manage their diabetes mellitus and prevent or delay diabetes related complications. So, the nurses should focus on each person with Type 2 diabetes and evaluate the patients to facilitate greater understanding of the patients? knowledge structures to have the plan for health education in accordance with their individual conditions, circumstances and culture.