A Community-based Randomized Double Blind Controlled Trial of Lactobacillus paracasei and Bifidobacterium lactis on Reducing Risk for Diarrhea and Fever in Preschool Children in an Urban Slum in India

Hemalatha, R.; Ouwehand, Arthur C.; Forssten, Sofia D.; Geddan, J. J. Babu; Mamidi, Raja Sriswan; Bhaskar, V. Vijaya; Radhakrishna, K. V.

doi:10.9734/ejnfs/2014/8280

Cited by 17 publications

(35 citation statements)

References 29 publications

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“…[8] In the placebo group, the counts of these organisms did not change over time [8] and were only correlated to iso-valeric acid, lactic acid and propionic acid. It is uncertain to what extent these correlations have contributed to the reduced incidence of fever and diarrhoea during the rainy season that was observed.…”

Section: Discussionmentioning

confidence: 99%

Effect of probiotic supplementation on total lactobacilli, bifidobacteria and short chain fatty acids in 2–5-year-old children

Hemalatha

Ouwehand

Saarinen

et al. 2017

Microbial Ecology in Health and Disease

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ABSTRACTBackground: Consumption of Lactobacillus paracasei Lpc-37 or Bifidobacterium lactis HN019 by 2–5-year-old children was found to reduce risk for diarrhoea and fever during the rainy season. Objective: Can changes in faecal short chain fatty acids (SCFAs) or branched chain fatty acids (BCFAs) explain the observed positive influence of probiotics and their role on nutritional status and diarrhoea risk? Design: Faecal samples were analysed for SCFAs and BCFAs and correlated to Bifidobacterium and Lactobacillus levels; both at the start and after nine months’ consumption of either of the two probiotic strains, or placebo. Results: No differences in SCFAs, BCFAs, Lactobacillus or Bifidobacterium levels were found between boys and girls. Severely underweight children were observed to have the highest Lactobacillus levels. Probiotic intervention was found to be associated with higher levels of selected SCFAs and BCFAs in subjects who had experienced diarrhoea. Treatment with either of the probiotics led to changes in SCFAs and BCFAs. SCFAs, acetate, propionate and butyrate, were found to correlate with each other. Likewise, BCFAs isobutyrate, 2-methylbutyrate and isovalerate correlated with each other. After the intervention, L. paracasei Lpc-37 correlated positively with total Bifidobacterium counts and isovalerate levels. B. lactis HN019 counts were found to correlate positively with total bacterial counts and negatively with propionate levels. Conclusions: Nutritional status was associated with higher levels of faecal lactobacilli; the meaning of this requires further investigation. The intervention with the two probiotics was observed to influence the levels of faecal SCFAs and BCFAs and there is a differential response in those who developed diarrhoea and those who did not. It is, however, not clear to what extent this is a mechanism that explains the earlier observed effect the strains had on diarrhoea risk.

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Section: Discussionmentioning

confidence: 99%

Effect of probiotic supplementation on total lactobacilli, bifidobacteria and short chain fatty acids in 2–5-year-old children

Hemalatha

Ouwehand

Saarinen

et al. 2017

Microbial Ecology in Health and Disease

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“…Neither probiotic had any effect on their growth in terms of height and weight, nor was there any difference in incidence of diarrhoea and fever between the groups. However, during the rainy season, when there is higher risk of diarrhoea, there were significantly fewer diarrhoea episodes in the two probiotic groups compared to placebo (Hemalatha et al 2014).…”

Section: Probiotics In Dairy Applications: a Science And Technology Rmentioning

confidence: 87%

“…However, during the rainy season, when there is higher risk of diarrhoea, there were significantly fewer diarrhoea episodes in the two probiotic groups compared to placebo (Hemalatha et al . ).…”

Section: Probiotics In Dairy Applications: a Science And Technology Rmentioning

confidence: 97%

Probiotics– the journey continues

Thomas¹

2016

Int J of Dairy Tech

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Papers from the recent Society of Dairy Technology's spring conference on probiotics are reviewed. Legislation relating to probiotic health claims was outlined, with comparison of the EU with other countries, including Japan. Research evidence for numerous probiotic benefits was described, with particular focus on obesity‐related disorders, antibiotic‐associated diarrhoea, infections and cancer. The mechanisms of activity underlying these effects were explained. Research on the gut microbiota early and late in life was presented, with examples of new product development. The physicochemical and microbial considerations for probiotic delivery in a cheese matrix were discussed, and the manufacturing process for galacto‐oligosaccharides used in infant formula was outlined.

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“…Some earlier studies have assessed whether probiotics are detectable in human feces after consumption by healthy volunteers. The strains included in the current study have all been reported to survive gastrointestinal transit and have been detected in feces: L. acidophilus NCFM [12,13]; L. paracasei Lpc-37 [14]; B. lactis Bl-04 [12], and B. lactis Bi-07 [15]. Moreover, other probiotic strains have been reported to be detected in feces after consumption, e.g., Lactobacillus rhamnosus GG and B. lactis Bb-12 [11].…”

Section: Discussionmentioning

confidence: 98%

Fecal Recovery of Probiotics Administered as a Multi-Strain Formulation during Antibiotic Treatment

2020

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The present study aimed to investigate whether probiotic recovery is affected when consumed together with antibiotics. Fecal samples were collected from an earlier antibiotic associated diarrhea, randomized, placebo-controlled study with a product consisting of a combination of Lactobacillus acidophilus NCFM, Lactobacillus paracasei Lpc-37, and Bifidobacterium lactis Bi-07, B. lactis Bl-04 at equal numbers and at a total dose of 1010 CFU. Fecal samples were collected during the screening visit (T0), i.e., at the time of antibiotic prescription, and then on the last day of the antibiotic treatment (T1) as well as seven days after the subject had stopped taking the antibiotic treatment (T2) and at two weeks after completing antibiotic treatment and one week after probiotic/placebo consumption stopped (T3). Samples were analyzed for the presence of the four administered strains. The study was registered at clinicaltrials.gov as NCT01596829. Detection levels of all four strains were significantly increased from T0 to T1 and returned to baseline level from T2 to T3. There were also significantly more subjects with detectable levels of L. paracasei Lpc-37, B. lactis Bi-07, and B. lactis Bl-04 at T1 and T2 compared to T0 and T3, and compared to placebo. Each of the four strains could be detected in the feces of patients apparently unaffected by the simultaneous consumption of antibiotics.

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A Community-based Randomized Double Blind Controlled Trial of Lactobacillus paracasei and Bifidobacterium lactis on Reducing Risk for Diarrhea and Fever in Preschool Children in an Urban Slum in India

Cited by 17 publications

References 29 publications

Effect of probiotic supplementation on total lactobacilli, bifidobacteria and short chain fatty acids in 2–5-year-old children

Effect of probiotic supplementation on total lactobacilli, bifidobacteria and short chain fatty acids in 2–5-year-old children

Probiotics– the journey continues

Fecal Recovery of Probiotics Administered as a Multi-Strain Formulation during Antibiotic Treatment

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