A Community-based RCT for Oral Cancer Screening with Toluidine Blue

Su, William Wang Yu; Yen, Amy Ming Fang; Chiu, Sherry Yueh Hsia; Chen, Chien-Jen

doi:10.1177/0022034510373763

Cited by 44 publications

(28 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It has been claimed that TB staining has a higher detection rate of oral PMDs and could further reduce the incidence of oral cancer compared to conventional visual inspection (Su et al 2010). However, TB staining can yield a high percentage of false positive results.…”

Section: Toluidine Blue Stainingmentioning

confidence: 99%

Non-Invasive Techniques for Detection and Diagnosis of Oral Potentially Malignant Disorders

Liu

Zhao

Zeng

et al. 2016

Tohoku J. Exp. Med.

View full text Add to dashboard Cite

Oral squamous cell carcinoma (OSCC) is the most common oral and maxillofacial malignancy, and its morbidity and mortality rates are still high in most countries. Oral potentially malignant disorders (PMDs) are used to refer to a heterogeneous group of conditions that are characterized by increased risk for malignant transformation to OSCC. Currently identified oral PMDs include leukoplakia, erythroplakia, palatal lesions associated with reverse smoking, oral lichen planus, oral submucous fibrosis, actinic keratosis, and discoid lupus erythematosus. The early detection and diagnosis of these lesions are important for cancer prevention and disease management. In recent years, there has been a growing and persistent demand for new non-invasive, practical diagnostic techniques that might facilitate the early detection of oral PMDs. The non-invasive detection techniques evaluated in this review are divided into four categories: vital staining with a solution that can be used as a mouth rinse or applied onto a suspected area of the mouth, light-based detection systems, optical diagnostic technologies that employ returned optical signals to reflect structural and morphological changes within tissues, and salivary biomarkers. Most of these techniques have shown great potential for screening and monitoring oral PMDs. In this review article, the authors critically assess these non-invasive detection techniques for oral PMDs. We also provide a summary of the sensitivity and specificity of each technique in detecting oral PMDs and oral cancer, as well as their advantages, disadvantages, clinical applications, and indications.

show abstract

Section: Toluidine Blue Stainingmentioning

confidence: 99%

Non-Invasive Techniques for Detection and Diagnosis of Oral Potentially Malignant Disorders

Liu

Zhao

Zeng

et al. 2016

Tohoku J. Exp. Med.

View full text Add to dashboard Cite

show abstract

“…90,103 Current literature suggests that the use of TB by trained and experienced practitioners may be useful in high-risk patients in a specialist setting, as most TB studies have been conducted in specialist clinics on higher-risk patients or patients who already have a known lesion. 5,94 With only one published community-based randomised controlled trial (RCT), 104 there is insufficient data to support the use of TB as an adjunct to COE in general practice on the general population. In this RCT, 7,975 participants were randomly allocated to either the experimental group (TB) or the control group (placebo dye), and were visually examined by experienced dentists who were trained by an oral pathologist to detect oral lesions.…”

Section: Vital Tissue Stainingmentioning

confidence: 99%

“…Further RCTs in the general population with longer follow-up periods are needed to confirm these results, particularly since the malignant transformation of PMOLs has a long natural history. 104 Problems with experimental design and analysis of results are the main reasons contributing to the poor quality of many studies on TB. Care must be taken when interpreting and comparing results as methods and definitions are inconsistent.…”

Section: Vital Tissue Stainingmentioning

confidence: 99%

Oral Cancer and Potentially Cancerous Lesions - Early Detection and Diagnosis

Farah¹,

Ford²,

Allen³

et al. 2012

Oral Cancer

View full text Add to dashboard Cite

“…Thus, early detection of asymptomatic oral premalignant lesions (OPMLs), including oral submucous fibrosis (OSF), homogenous leukoplakia, non-homogenous leukoplakia, erythroplakia, etc. is imperative before their transformation into malignancies [18].…”

Section: Introductionmentioning

confidence: 99%

Diagnostic Modalities for Squamous Cell Carcinoma: An Extensive Review of Literature-Considering Toluidine Blue as a Useful Adjunct

Chhabra

Sapra

2014

J. Maxillofac. Oral Surg.

View full text Add to dashboard Cite

Introduction Oral Squamous Cell Carcinomas have been considered as the most prevalent malignancies in the head and neck region and are frequently undiagnosed until symptomatic with an advanced stage of disease. So there is an urgent need to device methods for the detection of oral premalignant lesions and oral cancer at an early stage in order to improve the survival rate for patients. A number of tests have been done for the detection of oral cancer which include oral brush biopsy, the Vizilite, oral autofluorescence including chemiluscence, photodynamic detection, toluidine blue staining, methylene blue staining, incisional biopsy and many more. Material The article reviews various diagnostic modalities available at present for detection of squamous cell carcinomas and oral epithelial dysplasias based on advanced PUBMED search of the English language literature from the year 1972 to present in order to help us select the most suitable among them fulfilling the desired criteria of being non-invasive, highly specific and sensitive, economically viable, having a scope to be used for mass screening, easy to process, having low inter examiner variability and possibly not requiring high expertise to conduct and interpret the results. Conclusion After reviewing various diagnostic modalities, we conclude that toluidine blue staining emerges as a clear winner among all these and it can act as a valuable adjunct to incisional biopsy in detection of oral cancer and may not substitute it except in certain circumstances when its results are carefully correlated with the patient history and clinical characteristics of the mucosal disorder, considering the fact that incisional biopsy has been reported to cause dissemination of cancer cells in the circulation there by increasing the possibility of metastasis. We must emphasize that toludine blue is a screening modality and not a diagnostic procedure like biopsy and hence cannot replace a confirmatory biopsy as a whole

show abstract

A Community-based RCT for Oral Cancer Screening with Toluidine Blue

Cited by 44 publications

References 26 publications

Non-Invasive Techniques for Detection and Diagnosis of Oral Potentially Malignant Disorders

Non-Invasive Techniques for Detection and Diagnosis of Oral Potentially Malignant Disorders

Oral Cancer and Potentially Cancerous Lesions - Early Detection and Diagnosis

Diagnostic Modalities for Squamous Cell Carcinoma: An Extensive Review of Literature-Considering Toluidine Blue as a Useful Adjunct

Contact Info

Product

Resources

About