A Community Cross-Sectional Survey of Medical Problems in 440 Children with Down Syndrome in New York State

Roizen, Nancy; Magyar, Caroline I.; Kuschner, Emily S.; Sulkes, Stephen; Druschel, Charlotte M.; Wijngaarden, Edwin van; Rodgers, Lisa; Diehl, Alison; Lowry, Richard; Hyman, Susan

doi:10.1016/j.jpeds.2013.11.032

Cited by 71 publications

(53 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…DS is frequently associated with other medical problems, 1 which may have negative repercussions on the quality of life and longevity of these patients. Among these clinical problems, thyroid pathology is a primary area of concern, 2 this being testified to the American Academy of Pediatrics recommendation that thyroid function should be evaluated at 6 and 12 months and annually thereafter in all children with DS.…”

Section: Introductionmentioning

confidence: 99%

Peculiarities of presentation and evolution over time of Hashimoto’s thyroiditis in children and adolescents with Down’s syndrome

Aversa¹,

Salerno²,

Radetti³

et al. 2015

View full text Add to dashboard Cite

BACKGROUND: Studies concerning presentation and evolution over time of Hashimoto's thyroiditis (HT) in children with Down's syndrome (DS) are few, are based on limited study populations and do not include control HT groups without DS. The aim of this multicenter study was to shed further light on the relationships between DS and HT in childhood. DE-SIGN: In this retrospective study we compared thyroid function patterns at HT presentation in 2 groups of children with (group A) or without DS (group B), including 146 and 553 cases, respectively. All group A patients were subsequently re-examined after a median interval of 5.1 years in order to prospectively re-evaluate the evolution over time of thyroid function patterns in DS. RESULTS: In group A, female predominance, age at HT diagnosis and rates of familiarity for thyroid diseases were significantly lower than in group B, whilst the association with non-thyroidal autoimmune diseases was more frequent. The hormonal patterns that were most frequently found in the 2 groups were, respectively, subclinical hypothyroidism (in group A) and euthyroidism (in group B). Thyroid dysfunctions were, overall, more frequent in group A (86.3 vs 45.7%, p<0.001). At re-evaluation, DS children exhibited further deterioration of thyroid function with some cases switching towards Graves' disease (GD). CONCLUSIONS HT in DS children: a) presents earlier, is not associated with female predominance and is more frequently associated with other autoimmune diseases; b) presents only very infrequently with a euthyroid hormonal profile; c) in a limited rate of cases switches with time to GD.

show abstract

Section: Introductionmentioning

confidence: 99%

Peculiarities of presentation and evolution over time of Hashimoto’s thyroiditis in children and adolescents with Down’s syndrome

Aversa¹,

Salerno²,

Radetti³

et al. 2015

View full text Add to dashboard Cite

show abstract

“…Few studies have investigated comorbidities in children with DS through application of the AAP Guidelines [4][5][6]. These investigations are significant in establishing a baseline to better understand this population.…”

Section: Introductionmentioning

confidence: 99%

“…This is especially evident with autoimmune thyroid conditions (7-50%), seizures (1-10%), infantile spasms (3-15%), autism (1-7%) and obstructive sleep apnea (OSA) (30-60%), where reported frequencies vary widely [7][8][9][10]. An improved understanding of the complications Until recently, published articles have mostly relied on surveys and parental report with limited data collection from DS clinics [4,6,11]. Parental reports are limited by a reliance on the parent's ability to recall medical histories accurately.…”

Section: Introductionmentioning

confidence: 99%

Pediatric Comorbidities and Medical Complications Identified in Children with Down Syndrome

Hickey¹,

Wolter‐Warmerdam²,

Hickey³

et al. 2017

J Down Syndr Chr Abnorm

View full text Add to dashboard Cite

Objective: Children with Down syndrome (DS) have an increased risk of neonatal complications and comorbidities compared to the general population; however, the incidence, optimal screening intervals and outcomes in this population are uncertain. The purpose of this study is to phenotypically define this population of children with DS using a large multi-age and ethnic sample and current American Academy of Pediatrics (AAP) Guidelines testing practices.Method: This is a retrospective review of a large cohort of 1,108 children with DS (male=602; mean age at initial contact: 5.72 years, SD ± 5.51) who received care at the Sie Center for Down Syndrome (SCDS) at The Children's Hospital Colorado from 2011 and 2016. Clinical data were collected from a prospective patient clinic database. Clinical details were collected, which included demographics, prenatal and birth history and complications, comorbidities, procedures, treatment plans and outcomes.Results: Medical complications requiring admission to the neonatal intensive care unit were identified in 70.6% of children with DS. Frequent causes for these neonatal admissions included: Required oxygen (60.7%), feeding problem (48.2%), Respiratory Distress Syndrome (21.4%) and pulmonary hypertension (14.7%). Incidence of medical comorbidities in our population with DS included cardiac defects (64.3%), abnormal sleep study (71.1%), abnormal thyroid study (29.1%), pulmonary aspiration (12.2%), celiac disease (5.0%) and pulmonary arterial hypertension (28.3%). Conclusion:Clinical data provides results from one of the largest investigations at a single pediatric hospital for children and young adults with DS in the US. This study describes the comorbidities affecting individuals with DS more accurately by applying AAP guidelines in studying a larger population than previously defined. This result improves our understanding of the incidence and identification of medical conditions in children with DS and reinforces recommendations on medical care screening for individuals with DS.

show abstract

“…Individuals with Down's syndrome are known to be more likely to have a number of health conditions including cardiovascular disease, lipid metabolic disorders, recurrent infections particularly of the gastrointestinal tract and respiratory system (Adelekan et al, 2012;Roizen et al, 2014;Henderson et al, 2007;Malt et al, 2013). In addition people with Down's syndrome have estimated prevalence rates of 7-50% for thyroid disease, 4% for type 1 diabetes and between 2.5% and 33% for coeliac disease (Malt et al, 2013;Noori et al, 2016).…”

mentioning

confidence: 99%

“…The large divergence in results from 2.5 to 33% prevalence of coeliac disease in people with Down's syndrome is due to a combination of sample selection (including geographical area, recruitment process and size of cohort) and the screening method employed by the researchers with IgA-EMA markers resulting in higher prevalence rates and diagnosis confirmed by biopsy resulting in lower rates of diagnosis (Uibo et al, 2006). Trends across studies from a range of countries have pointed to a consensus of around 6% of individuals with Down's syndrome who have coeliac disease (Szaflarska-Popławskaet al, 2016;Nisihara et al, 2005;Roizen et al, 2014;Goldacre et al, 2004;Nisihara et al, 2005). This may prove to be a conservative estimate given the known underrepresentation due to atypical and latent coeliac disease (Admou et al, 2012) and diagnostic over shadowing within people who have cognitive impairments.…”

mentioning

confidence: 99%

Prevalence and management of coeliac disease in people with Down’s syndrome

Harper

2018

Learning Disability Practice

View full text Add to dashboard Cite

A Community Cross-Sectional Survey of Medical Problems in 440 Children with Down Syndrome in New York State

Cited by 71 publications

References 17 publications

Peculiarities of presentation and evolution over time of Hashimoto’s thyroiditis in children and adolescents with Down’s syndrome

Peculiarities of presentation and evolution over time of Hashimoto’s thyroiditis in children and adolescents with Down’s syndrome

Pediatric Comorbidities and Medical Complications Identified in Children with Down Syndrome

Prevalence and management of coeliac disease in people with Down’s syndrome

Contact Info

Product

Resources

About