A hexagonal cavity backed antenna based on HMSIW is proposed to operate at 5.2 GHz and 5.8 GHz frequencies. The TM 010 and TM 110 modes of the hexagonal cavity resonator have been chosen to excite the structure. Afterwards, an HMSIW hexagonal cavity is formed by splitting conventional hexagonal cavity resonator along a magnetic wall. This enables a 50% reduction in size without affecting the antenna operating frequency. A rectangular slot is etched at the centre of the magnetic wall to curtail TM 110 mode operating frequency. The dimensions of the slot are optimized to adapt TM 110 resonant frequency to the desired frequency. In free space, the resulting antenna accomplished a peak gain of 5.5 dB and 4.3 dB at centre frequencies of 5.2 GHz and 5.8 GHz, respectively. In the vicinity of pork tissues, the antenna exhibits a peak gain of 4 dB at 5.8 GHz along with an efficiency of 87.2%.