In this article, a rectangular dielectric resonator (DR) based multiple input multiple output (MIMO) hybrid antenna with a machine learning (ML) optimization approach for 5G New Radio (NR), WiMAX, WLAN, Wi‐Fi 6, Vehicle to Everything (V2X), and C‐band uplink applications are presented. The proposed antenna provides a triple band. It covers n1, n2, and n39 5G NR at a lower frequency (1.59–2.26 GHz), n48 5G NR at the middle frequency (3.1–3.87 GHz), and n46, n47, n96, WiMAX, WLAN, and C‐band uplink at higher frequency (5.25–6.91 GHz). It achieved more than 20% impedance bandwidth and 20 dB isolation in all frequency bands. The maximum gain of the proposed antenna is 15 dBi. The calculated MIMO parameters are within the accepted range. It is optimized through various ML algorithms, including random forest (RF), K‐nearest neighbor (KNN), artificial neural network (ANN), extreme gradient boosting (XGB) and decision tree (DT). The RF ML algorithm gives 98.09% accuracy compared to other ML algorithms for S parameter prediction.