This paper provides an overview of balanced (or differential-mode) structures operating at microwaves, including common-mode suppression filters, balanced filters and circuits with intrinsic common-mode suppression, and differential-mode sensors. The increasing interest for balanced structures within the framework of communication circuits and sensors, related to their major robustness against electromagnetic interference (EMI), noise, and environmental factors, is duly justified. Then the paper reports various approaches for the implementation of common-mode suppression filters, balanced filters and circuits (including narrowband and wideband filters, multi-band filters, power dividers, couplers and phase shifters), and differential-mode sensors (mainly devoted to the measurement of permittivity and related variables). Rather than providing a detailed analysis of the different considered implementations/approaches, the main goal of this review paper is to discuss, and compare in some cases, the main proposed strategies (pointed out in the up-to-date state-of-the-art) for optimizing the performance of the various differential-mode devices under study.