A comparative analysis of premature heart disease- and cancer-related mortality in women in the USA, 1999–2018

Khan, Safi U.; Yedlapati, Siva Harsha; Lone, Ahmad Naeem; Khan, Muhammad Shahzeb; Wenger, Nanette K.; Watson, Karol E.; Gulati, Martha; Hays, Allison G.; Michos, Erin D.

doi:10.1093/ehjqcco/qcaa099

Cited by 36 publications

(18 citation statements)

References 50 publications

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“…As heart disease is rising, particularly in younger women, PPCM remains an important public health concern. 15 Further studies are needed to better understand the contributing factors of increased risk for cardiovascular complications across racial subgroups.…”

Section: Discussionmentioning

confidence: 99%

Racial Differences in Delivery Outcomes Among Women With Peripartum Cardiomyopathy

et al. 2022

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This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

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Section: Discussionmentioning

confidence: 99%

Racial Differences in Delivery Outcomes Among Women With Peripartum Cardiomyopathy

et al. 2022

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“…Similar to the findings reported in our study, age‐adjusted mortality from premature CV disease saw a decline in both men and women. Khan et al 24 showed a reduction in the mortality gap between cancer and heart disease among women aged <65 years of age. There was an overall reduction in mortality in this subgroup of women in cancer and CV disease but more significantly in the cancer group.…”

Section: Discussionmentioning

confidence: 99%

Trends in cardiovascular mortality of cancer patients in the US over two decades 1999‐2019

et al. 2021

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Background Cancer is the second most common cause of death globally after cardiovascular disease, and cancer patients are at an increased risk of CV death. This recognition has led to publication of cardio‐oncological guidelines and to the widespread adoption of dedicated cardio‐oncology services in many institutes. However, it is unclear whether there has been a change in the incidence of CV death in cancer patients. Methods and Results Using Centers for Disease Control and Prevention Wide‐Ranging, Online Data for Epidemiologic Research (CDC WONDER) Multiple Cause of Death dataset, we determined national trends in age‐standardised mortality rates attributed to cardiovascular diseases in patients with and without cancer, from 1999 to 2019, stratified by cancer type, age, gender, race, and place of residence (state and urbanisation status). Among more than 17.8 million cardiovascular deaths in the United States, 13.6% were patients with a concomitant cancer diagnosis. During the study period, among patients with cancer, the age‐adjusted mortality rate dropped by 52% (vs 38% in patients with no cancer). In cancer patients, age‐adjusted mortality rate dropped more significantly among patients with gastrointestinal, breast, and prostate malignancy than among patients with haematological malignancy (59%‐63% vs. 41%). Similar reduction was observed in both genders (53%‐54%), but more prominent reduction was observed in older patients and in those living in metro areas. Conclusions Our findings emphasise the role of multidisciplinary management of cancer patients. Widespread adoption of cardio oncology services have the potential to impact the inherent risk of increased CV mortality in both cancer patients and survivors.

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“…Cardiovascular disease (CVD) continues to be the leading cause of death for women worldwide, and rates of CVD and stroke are increasing in women aged <45 years (1,2). Certain complications of pregnancy, including hypertensive disorders of pregnancy, gestational diabetes mellitus, intrauterine growth restriction, spontaneous preterm birth, and placental abruption, are established independent risk factors for premature cardiovascular disease in women (3)(4)(5)(6)(7)(8)(9).…”

Section: Introductionmentioning

confidence: 99%

Prevalence of Metabolic Syndrome in Women After Maternal Complications of Pregnancy: An Observational Cohort Analysis

Aldridge

Pathirana

Wittwer

et al. 2022

Front. Cardiovasc. Med.

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IntroductionCertain complications of pregnancy, including hypertensive disorders of pregnancy, gestational diabetes mellitus, intrauterine growth restriction, spontaneous preterm birth, and placental abruption, are established independent risk factors for premature cardiovascular disease in women. Metabolic syndrome, which is associated with an increased risk of cardiovascular disease, may be a suitable alternative to traditional cardiovascular risk calculators that underestimate risk in young women. This study aimed to investigate the prevalence of metabolic syndrome in women who experienced a complicated pregnancy 6 months earlier.MethodsThis observational study investigated the prevalence of metabolic syndrome as defined by the International Diabetes Federation in all eligible participants (n = 247) attending a postpartum lifestyle intervention clinic from August 2018 to June 2021 at the Lyell McEwin Hospital in Adelaide, South Australia.ResultsA total of 89 (36%) participants met the criteria for metabolic syndrome at a mean follow up time of 7 months postpartum. Almost 90% of the cohort were abdominally obese, and over two thirds of the total cohort met at least two of the criteria for metabolic syndrome.ConclusionsWomen with a prior history of one of the common major pregnancy complications are at high risk of future cardiovascular and metabolic disease, with many showing either metabolic syndrome or multiple risk factors at only 7 months postpartum. The results indicate that follow-up within 1 year postpartum is an appropriate time to commence preventative strategies, as many women are already showing early signs of disease.

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A comparative analysis of premature heart disease- and cancer-related mortality in women in the USA, 1999–2018

Cited by 36 publications

References 50 publications

Racial Differences in Delivery Outcomes Among Women With Peripartum Cardiomyopathy

Racial Differences in Delivery Outcomes Among Women With Peripartum Cardiomyopathy

Trends in cardiovascular mortality of cancer patients in the US over two decades 1999‐2019

Prevalence of Metabolic Syndrome in Women After Maternal Complications of Pregnancy: An Observational Cohort Analysis

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