A comparative analysis of the effects of Medetomidine and Dexmedetomidine on hemodynamic parameters in cats. Technical note

Abstract

Hemodynamic parameters are clinical indicators used in Human and Veterinary Medicine to assess the general health status of patients and identify potential risks. Alpha–2 adrenoceptor agonists, such as Medetomidine and Dexmedetomidine, are known to produce dose–dependent premedication ranging from mild to profound and have significant cardiovascular effects. This study aimed to evaluate the effects of these commonly used alpha–2 adrenoceptor agonists on hemodynamic parameters, particularly blood pressure. To achieve this, 100 cats aged between 6 months and 7 years old ere randomly divided into two groups. Hemodynamic parameters were analyzed both before and 5 minutes after premedication with either Medetomidine or Dexmedetomidine. Although there were significant changes in hemodynamic parameters before and after premedication within each group, no statistically significant differences were observed between the Medetomidine and Dexmedetomidine groups. In conclusion, the effects of equivalent doses of Medetomidine and Dexmedetomidine on hemodynamic parameters were found to be similar in cats.