A comparative analysis of two unrelated outbreaks in Latvia and Australia of acquired idiopathic megaesophagus in dogs fed two brands of commercial dry dog foods: 398 cases (2014–2018)

Hurley, Karyl J.; Mansfield, Caroline; VanHoutan, Ilze Matīse; Lacorcia, Lauren; Allenspach, Karin; Hebbard, Geoffrey; Marks, Stanley L.; Poppenga, Robert H.; Kaufman, James H.; Weimer, Bart C.; Woolard, Kevin D.; Bielitzki, Joe; Lulham, Derek; Naar, Jérôme

doi:10.2460/javma.259.2.172

Cited by 4 publications

(4 citation statements)

References 13 publications

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“…It should be remembered these outbreaks are rare and the pet food industry is held to high standards in the UK. As home‐produced diets can also cause disease in pets, 48 veterinary surgeons should take care to reassure their clients that commercial food is generally safe 46 . However, these recurrent world‐wide events also highlight the urgent need for establishing a better framework for investigating suspected foodborne disease outbreaks, with a possible solution modeled in Australia with the Pet Food Adverse Event System of Tracking (PetFAST).…”

Section: Discussionmentioning

confidence: 99%

“…Once a possible association with diets was made, this allowed notification of the Food Standards Agency to lead the investigation which led to a voluntary full product recall of brands A, B and C. Various disease outbreaks secondary to commercial pet food ingestion are reported around the world, including acute kidney injury because of melamine and cyanuric acid feed contamination, 41 , 42 acute kidney injury and hypercalcemia because of excessive vitamin D feed supplementation, 43 dietary associated acquired renal proximal tubulopathy, 44 hepatotoxicosis because of indscopine feed contamination, 45 dietary associated acquired megaesophagus 46 and demyelination secondary to irradiation of feed. 47 It should be remembered these outbreaks are rare and the pet food industry is held to high standards in the UK.…”

Section: Discussionmentioning

confidence: 99%

“…As home‐produced diets can also cause disease in pets, 48 veterinary surgeons should take care to reassure their clients that commercial food is generally safe. 46 However, these recurrent world‐wide events also highlight the urgent need for establishing a better framework for investigating suspected foodborne disease outbreaks, with a possible solution modeled in Australia with the Pet Food Adverse Event System of Tracking (PetFAST). This is a veterinary reporting system to track suspected adverse events related to pet food, pet meat and treats which is used to identify possible patterns indicating a problem.…”

Section: Discussionmentioning

confidence: 99%

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An investigation into an outbreak of pancytopenia in cats in the United Kingdom

Glanemann

Humm

Pegram

et al. 2023

Veterinary Internal Medicne

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Background In spring 2021 increasing numbers of cats presenting with severe pancytopenia were noted in United Kingdom (UK). Objective To describe process and outcome of the investigation performed into the outbreak of pancytopenia in cats. Animals Five hundred and eighty client owned cats that presented with severe bi‐ or pancytopenia of unknown cause. Methods Real‐time data collection was performed by an online registration forum available to all veterinary surgeons in UK. Data collected included demographics, clinicopathological findings, diagnostic testing, dietary and drug history, outcome and COVID household status. Mycotoxicological feed analysis was performed on feed samples of 3 diets frequently mentioned in the database and 3 control diets. Results Five hundred and eighty cats presented to 378 veterinary practices were included for analysis. Case fatality rate was 63.3%. Dietary history was available for 544 (93.8%) cats, of which 500 (86%) were fed 1 of 3 diets (which were recalled midinvestigation). 54 (9.3%) cats were not fed a recalled product, with diet information unknown in 26 (4.5%) cats. Analysis of feed samples revealed concentrations of hematotoxic trichothecene T‐2/HT‐2 mycotoxins greater than recommended by the European Commission in 5/7 recalled diet samples but in none of control diet samples. The trichothecene mycotoxin diacetoxyscirpenol (DAS) was detectable in all recalled diet samples but not in any of control samples. Conclusion and Clinical Importance Contaminated‐feed induced trichothecene mycotoxicosis should be considered as a differential diagnosis for pancytopenia in cats.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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An investigation into an outbreak of pancytopenia in cats in the United Kingdom

Glanemann

Humm

Pegram

et al. 2023

Veterinary Internal Medicne

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“…Similar genomic analyses could be fruitful in patients with esophageal achalasia and secondary megaesophagus. Further study in dogs could also uncover environmental factors associated with esophageal achalasia and/or secondary megaesophagus, such as toxins (aflatoxin) (389) or dietary ingredients (390). Esophageal achalasia can even be experimentally induced in canines by injecting a surfactant, benzyldimethyltetradecylammonium chloride into the LES.…”

Section: Models For Translational Research and Medicinementioning

confidence: 99%

A Comparative Assessment of the Diagnosis of Swallowing Impairment and Gastroesophageal Reflux in Canines and Humans

et al. 2022

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Swallowing impairment is a highly prevalent and clinically significant problem affecting people and dogs. There are myriad causes of swallowing impairment of which gastroesophageal reflux is the most common in both species. Similarities in anatomy and physiology between humans and canines results in analogous swallowing disorders including cricopharyngeus muscle achalasia, esophageal achalasia, hiatal herniation, and gastroesophageal reflux with secondary esophagitis and esophageal dysmotility. Accordingly, the diagnostic approach to human and canine patients with swallowing impairment is similar. Diagnostic procedures such as swallowing fluoroscopy, high-resolution manometry, pH/impedance monitoring, and endolumenal functional luminal imaging probe can be performed in both species; however, nasofacial conformation, increased esophageal length, and the difficulty of completing several of these procedures in awake dogs are inherent challenges that need to be considered. Human patients can convey their symptoms and respond to verbal cues, whereas veterinarians must rely on clinical histories narrated by pet owners followed by comprehensive physical examination and observation of the animal eating different food consistencies and drinking water. Dogs may also be unwilling to drink or eat in the hospital setting and may be resistant to physical restraint during diagnostic procedures. Despite the species differences and diagnostic challenges, dogs are a natural animal model for many oropharyngeal and esophageal disorders affecting people, which presents a tremendous opportunity for shared learnings. This manuscript reviews the comparative aspects of esophageal anatomy and physiology between humans and canines, summarizes the diagnostic assessment of swallowing impairment in both species, and discusses future considerations for collaborative medicine and translational research.

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Physiology, Pathophysiology, and Anesthetic Management of Patients with Gastrointestinal Disease

Adams

2024

Veterinary Anesthesia and Analgesia

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A comparative analysis of two unrelated outbreaks in Latvia and Australia of acquired idiopathic megaesophagus in dogs fed two brands of commercial dry dog foods: 398 cases (2014–2018)

Abstract: In the first quarter of 2015, veterinarians in Latvia observed a year-over-year increase in dogs that had

Cited by 4 publications

References 13 publications

An investigation into an outbreak of pancytopenia in cats in the United Kingdom

An investigation into an outbreak of pancytopenia in cats in the United Kingdom

A Comparative Assessment of the Diagnosis of Swallowing Impairment and Gastroesophageal Reflux in Canines and Humans

Physiology, Pathophysiology, and Anesthetic Management of Patients with Gastrointestinal Disease

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