A comparative cellular and molecular biology of longevity database

Stuart, Jeffrey A.; Liang, Ping; Luo, Xi; Page, Melissa M.; Gallagher, Emily J.; Christoff, Casey A.; Robb, Ellen L.

doi:10.1007/s11357-012-9458-y

Cited by 15 publications

(9 citation statements)

References 44 publications

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“…For example, GenAge has been used as the basis for all the longevity networks hosted in the NetAge database [(30); http://netage-project.org], is featured in JenaLib [(31); http://www.fli-leibniz.de/IMAGE.html] and participates in LinkOut from NCBI resources like OMIM and Entrez Gene (32). AnAge is a content partner of the Encyclopedia of Life (http://eol.org), and its data have also been incorporated into the Biology of Ageing (http://biologyofaging.org) portal, the Animal Diversity Web (http://animaldiversity.ummz.umich.edu) and the Comparative Cellular and Molecular Biology of Longevity Database [(33); http://genomics.brocku.ca/ccmbl/]. …”

Section: Discussionmentioning

confidence: 99%

Human Ageing Genomic Resources: Integrated databases and tools for the biology and genetics of ageing

Tăcutu

Craig

Budovsky

et al. 2012

Nucleic Acids Research

502

557

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The Human Ageing Genomic Resources (HAGR, http://genomics.senescence.info) is a freely available online collection of research databases and tools for the biology and genetics of ageing. HAGR features now several databases with high-quality manually curated data: (i) GenAge, a database of genes associated with ageing in humans and model organisms; (ii) AnAge, an extensive collection of longevity records and complementary traits for >4000 vertebrate species; and (iii) GenDR, a newly incorporated database, containing both gene mutations that interfere with dietary restriction-mediated lifespan extension and consistent gene expression changes induced by dietary restriction. Since its creation about 10 years ago, major efforts have been undertaken to maintain the quality of data in HAGR, while further continuing to develop, improve and extend it. This article briefly describes the content of HAGR and details the major updates since its previous publications, in terms of both structure and content. The completely redesigned interface, more intuitive and more integrative of HAGR resources, is also presented. Altogether, we hope that through its improvements, the current version of HAGR will continue to provide users with the most comprehensive and accessible resources available today in the field of biogerontology.

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Section: Discussionmentioning

confidence: 99%

Human Ageing Genomic Resources: Integrated databases and tools for the biology and genetics of ageing

Tăcutu

Craig

Budovsky

et al. 2012

Nucleic Acids Research

502

557

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“…For example, one large-scale study using data from AnAge investigated how multiple ecological and mode-of-life traits affect lifespan ( 19 ). The data from AnAge have also been incorporated into the Comparative Cellular and Molecular Biology of Longevity Database ( http://genomics.brocku.ca/ccmbl/ ) ( 20 ), the MitoAge database ( http://www.mitoage.info ) ( 21 ), the Encyclopedia of Life ( http://eol.org/ ), and the Animal Diversity Web ( http://animaldiversity.ummz.umich.edu ), demonstrating the versatility of this resource.…”

Section: Database Contentmentioning

confidence: 99%

Human Ageing Genomic Resources: new and updated databases

Tăcutu

Thornton

Johnson

et al. 2017

Nucleic Acids Research

623

687

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In spite of a growing body of research and data, human ageing remains a poorly understood process. Over 10 years ago we developed the Human Ageing Genomic Resources (HAGR), a collection of databases and tools for studying the biology and genetics of ageing. Here, we present HAGR’s main functionalities, highlighting new additions and improvements. HAGR consists of six core databases: (i) the GenAge database of ageing-related genes, in turn composed of a dataset of >300 human ageing-related genes and a dataset with >2000 genes associated with ageing or longevity in model organisms; (ii) the AnAge database of animal ageing and longevity, featuring >4000 species; (iii) the GenDR database with >200 genes associated with the life-extending effects of dietary restriction; (iv) the LongevityMap database of human genetic association studies of longevity with >500 entries; (v) the DrugAge database with >400 ageing or longevity-associated drugs or compounds; (vi) the CellAge database with >200 genes associated with cell senescence. All our databases are manually curated by experts and regularly updated to ensure a high quality data. Cross-links across our databases and to external resources help researchers locate and integrate relevant information. HAGR is freely available online (http://genomics.senescence.info/).

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“…With the observation of the exceptional longevity of the ocean quahog Arctica islandica (Ridgway & Richardson 2011), bivalves are becoming also an attractive model for ageing studies (Abele et al 2009). Comparative biology of longevity determinants is an informative field that is progressively expanding its observations at the cellular level (Stuart et al 2013;Croco et al 2016Croco et al , 2017b.…”

Section: Introductionmentioning

confidence: 99%

Cell cultures of the Manila clam and their possible use in biomonitoring and species preservation

Attaallah

Marchionni

El-Beltagy

et al. 2020

The European Zoological Journal

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A huge progress has been achieved in mammalian in vitro technique. Instead, of the many trials to develop marine invertebrate cell cultures, only a few have obtained them and only from few tissues. Since in vitro cell culture of invertebrates could be very useful for many aspects of basic and applied science, in this work we investigate and describe the development of a technique for the establishment of cell cultures from gill, mantle and gonadic tissue of the Manila clam (Ruditapes philippinarum). We maintained viable cultures for up to 25 days. Culture viability and proliferation were tested with 3-(4,5-Dimethylthiazol-2-yl)-2,5-Diphenyltetrazolium Bromide (MTT) and with trypan blue, while an antibody against the ATP-dependent RNA helicase VASA, a protein expressed in the germline, and in multipotent stem cells of some animals, was used to verify the presence of these cell types. Following the described protocol: 1) explant resulted the better source to obtain cell cultures, when compared to enzymatic dissociation; 2) cultures of suspended cells were viable for longer period than adherent cells; 3) cell cultures obtained from tissues sampled in September-October performed better compared to other periods of the year, regarding maintenance and growth; 4) the tissue from which we obtained longer-lived cell cultures was gonadic tissue, especially form samples that show more undifferentiated germ cells and more VASA-stained cells. This study describes the challenges concerning the development of in vitro culture techniques for aquatic invertebrates.

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A comparative cellular and molecular biology of longevity database

Cited by 15 publications

References 44 publications

Human Ageing Genomic Resources: Integrated databases and tools for the biology and genetics of ageing

Human Ageing Genomic Resources: Integrated databases and tools for the biology and genetics of ageing

Human Ageing Genomic Resources: new and updated databases

Cell cultures of the Manila clam and their possible use in biomonitoring and species preservation

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