A comparative clinical evaluation of analgesic efficacy of Tapentadol and ketorolac in mandibular third molar surgery

Abstract

Introduction:The surgical removal of impacted mandibular third molars is one of the most commonly performed dentoalveolar procedures in oral and maxillofacial surgery and is associated with varying degrees of postoperative discomfort. Pain, trismus, and swelling are the most common postoperative complaints, and these influence a patient's quality of life in the days after surgery.Materials and Methods:A comparative study of the 32 patients, 16 were allocated to receive ketorolac and 16 patients were allocated to receive tapentadol. As the data for this study were collected at different time points, analysis for the longitudinal study was done. The main outcome variable, pain level was measured in five-ordered categories. As we had ordinal data in our study, we first checked for marginal homogeneity through Cochran–Mantel–Haenszel test.Results:In the present study, the results show that there is no statistically significant difference between the two treatment groups (P = 0.1184). According to results, there is no significant group by time interaction, which means both drugs have shown almost equal efficacy at different time points. Similarly, there is no difference in efficacy of the two drugs across gender level.Conclusion:The present findings showed that there is no statistically significant difference between the two treatment groups, although ketorolac is more effective for immediate pain reduction than tapentadol. However, the overall reduction of pain using both groups has no significant difference.

Comparative Evaluation Of Tapentadol And Tramadol In Reducing Pain Mandibular Third Molar Surgery

“…Also, Tapentadol does not have any abuse potential. 7,8,13 Limitations of this study was that it was a unicentric study and a multicentric randomized control trial should be conducted to corroborate the results of the study.…”

“…14 The commonly preferred opioid for pain management is Tramadol. 13 Since three decades tramadol is used as a centrally acting analgesic. 13 But the introduction of tramadol was slow in the market worldwide.…”

“…13 Since three decades tramadol is used as a centrally acting analgesic. 13 But the introduction of tramadol was slow in the market worldwide. Reason for this slow introduction was the issue or con ict with the safety of the drug.…”

Novel Techniques for Musculoskeletal Pain Management after Orthopedic Surgical Procedures: A Systematic Review

“…A notable randomized trial highlighted similar postoperative pain control and functional outcomes with an around-the-clock oral regimen of the atypical opioid tapentadol compared to oxycodone plus naloxone following minor orthopedic procedures [59]. While tapentadol was not superior to oxycodone, its non-inferiority supports the use of oral multimodal opioid-sparing analgesia as an alternative to traditional opioids for select surgical procedures and patients [85].…”

Tapentadol in acute pain: a review of the results of international studies

“…D. Shah и соавт. [17] сравнивали обезболивающий эффект тапентадола НВ 50 мг и кеторолака 10 мг у 32 пациентов после хирургической экстракции зуба. Эффективность препаратов была сравнимой, как и ин-…”