A comparative clinical study on the effect of Tagara (Valeriana wallichii DC.) and Jatamansi (Nardostachys jatamansi DC.) in the management of Anidra (primary insomnia)

Toolika, E; Bhat, Narayana Prakash; Shetty, Suhas Kumar

doi:10.4103/0974-8520.169008

Cited by 36 publications

(18 citation statements)

References 7 publications

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“…Although future research will be required to evaluate the value of this herb for diverse neuro-inflammatory disorders, previous reports confirm its ability to attenuate inflammation in LPS-activated RAW264.7 cells where it activates p38 MAPK/Nrf2/HO-1 pathways also reducing inflammation in cecal ligation-induced sepsis in mice. (Park et al, 2013) Lastly, Ganthoda ( Valeriana wallichii ), is a well known sleeping aid (valerian) (Toolika et al, 2015) having historic reputations as a traditional Chinese medicine for treating insomnia, nervous disorders, epilepsy, and vision impairment. Neuroprotective activities has been demonstrated due to activity or iridoids (Zhang and Ding, 2015) which are reportedly capable of attenuating DAergic degeneration in MPTP treated mice (Sridharan et al, 2015) and cerebral injury from stroke.…”

Section: Discussionmentioning

confidence: 99%

Natural product HTP screening for attenuation of cytokine-induced neutrophil chemo attractants (CINCs) and NO2− in LPS/IFNγ activated glioma cells

Mazzio

Bauer

Mendonca

et al. 2017

Journal of Neuroimmunology

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Chronic or acute central nervous system (CNS) inflammation is carried out by glial cells, which can contribute to neurological injuries associated with head trauma, stroke, and infection, Parkinson’s or Alzheimer ’s disease. The process of aging combined with inflammation are also risk factors for developing glioblastoma multiforme (GBM) as well as perpetuating its malignant aggression. With growing public curiosity in complementary and alternative medicines (CAMs), in this work we conduct a high throughput (HTP) screening of >1400 natural herbs, plants and over the counter (OTC) products for anti-inflammatory effects on lipopolysaccharide (LPS)/interferon gamma (IFNγ) activated C6 glioma cells. Validation studies suggest a pro-inflammatory profile mediated by LPS [3μg/ml/IFNγ 3ng/ml] is consistent with elevation [> 8.5 fold] of MCP-1 and cytokine-induced neutrophil chemo-attractants (CINC) 1, CINC 2a and CINC3. The data show no evidence of changes to the following, IL-13, TNF-a, fracktaline, leptin, LIX, GM-CSF, ICAM1, L-Selectin, activin A, agrin, IL-1α, MIP-3a, B72/CD86, NGF, IL-1b, MMP-8, IL-1 R6, PDGF-AA, IL-2, IL-4, prolactin R, RAGE, IL-6, Thymus Chemokine-1, CNTF,IL-10 or TIMP-1. The data also show a LPS/IFNγ mediated rise in iNOS and NO2− as often reported. A HTP screening was conducted, where we employ an in vitro efficacy index (iEI) defined as the ratio of toxicity (LC50)/anti-inflammatory potency (IC50) to ensure biological effects were occurring in fully viable cells (ratio > 3.8). Using NO2− as a guideline molecule, the data show that 1.77 % (25 of 1410 tested) (at <250μg/ml) had anti-inflammatory effects with an iEI ratio >3.8. These include reference drugs (hydrocortisone, dexamethasone N6-(1-iminoethyl)-L-lysine and NSAIDS : diclofenac, tolfenamic acid), a histone deacetylase inhibitor (apicidin) and the following natural products; Ashwaganda (Withania somnifera), Elecampagne Root (Inula helenium), Feverfew (Tanacetum parthenium), Green Tea (Camellia sinensis), Turmeric Root (Curcuma Longa) Ganthoda (Valeriana wallichii), Tansy (Tanacetum vulgare), Maddar Root (Rubia tinctoria), Red Sandle wood (Pterocarpus santalinus), Bay Leaf (Laurus nobilis, Lauraceae), quercetin, cardamonin, fisetin, EGCG, biochanin A, galangin, apigenin and curcumin. The herb with the largest iEI was Ashwaganda where the IC50/LC50 was 11.1/>1750.0 μg/mL, and the compound with the greatest iEI was quercetin where the IC50/LC50 was 10.0/>363.6 ug/mL. These substances also downregulate the production of iNOS expression and attenuate CINC-3 release. In summary, this HTP screening provides guideline information as to efficacy of natural products that in the long term, could prevent inflammatory processes associated with neurodegenerative disease and aggressive glioma tumor growth.

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Section: Discussionmentioning

confidence: 99%

Natural product HTP screening for attenuation of cytokine-induced neutrophil chemo attractants (CINCs) and NO2− in LPS/IFNγ activated glioma cells

Mazzio

Bauer

Mendonca

et al. 2017

Journal of Neuroimmunology

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“…Tagara, in which V. jatamansi is used as the key ingredient for the treatment of depression-type insomnia, has been marketed abroad (Singhal and Neetu, 2013). V. jatamansi contains IRFV, flavonoids, alkaloids, and volatile oils (Toolika et al, 2015). IRFV is the primary sedative and active component of V. jatamansi.…”

Section: Introductionmentioning

confidence: 99%

Serum Metabolic Profiling Reveals the Antidepressive Effects of the Total Iridoids of Valeriana jatamansi Jones on Chronic Unpredictable Mild Stress Mice

Chang

et al. 2020

Front. Pharmacol.

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Background: Depression is a long-term complex psychiatric disorder, and its etiology remains largely unknown. Valeriana jatamansi Jones ex Roxb (V. jatamansi) is used in the clinic for the treatment of depression, but there are insufficient reports of its antidepressive mechanisms and a poor understanding of its endogenous substance-related metabolism. The objective of this study was to identify biomarkers related to depression in serum samples and evaluate the antidepressive effects of the iridoid-rich fraction of V. jatamansi (IRFV) in a chronic unpredictable mild stress (CUMS) mouse model. Methods: Here, CUMS was used to establish a mouse model of depression. Behavioral and biochemical indicators were investigated to evaluate the pharmacodynamic effects. A comprehensive serum metabolomics study by nuclear magnetic resonance (NMR) approach was applied to investigate the pharmacological mechanism of IRFV in CUMS mouse. Subsequently, we used multivariate statistical analysis to identify metabolic markers, such as principal component analysis (PCA) and orthogonal projection to latent structure with discriminant analysis (OPLS-DA), to distinguish between the CUMS mouse and the control group. Results: After IRFV treatment, the immobility time, sucrose preference, and monoamine neurotransmitter were improved. PCA scores showed clear differences in metabolism between the CUMS group and control group. The PLS-DA or OPLS-DA model exhibited 26 metabolites as biomarkers to distinguish between the CUMS mice and the control mouse. Moreover, IRFV could significantly return 21 metabolites to normal levels. Conclusion: The results confirmed that IRFV exerted an antidepressive effect by regulating multiple metabolic pathways, including the tricarboxylic acid cycle, the synthesis of neurotransmitters, and amino acid metabolism. These findings provide insights into the antidepressive mechanisms of IRFV.

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“…is ideal. In cases of Insomnia, tagara (Valeriana wallichii) 11 , Somalata (Sarcostemma acidum) can be administered; it enhances the sleep quality and has neuro-protective activity.…”

Section: Ayurvedic Approachmentioning

confidence: 99%

Psychological Issues In Covid 19 Outbreak - Ayurvedic Approach

Sanker

Madhvan

2020

Asian J Pharm Res Dev

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Corona Virus Disease (COVID-19) is a newly revealed infectious disease declared as pandemic by WHO. Through its fast spreading nature it created an alarming situation throughout the globe. The only possible way to control the spread is to break the chain of transmission by keeping social distancing along with maintaining strict personal hygiene. A complete lockdown was the effective method chosen by the authorities in such a situation. The panic situation created by the disease along with the unfamiliar way of conduct imposed several psychological impacts on human life. Many can’t cope up with the situation on their own and are in need of an intervention such as Psychological First Aid. Fear, anxiety, future concerns, interpersonal relationships issues, behavioural issues, domestic abuses, separation anxiety are a few among the psychological issues reported. A well explained modality of psychotherapy mentioned in Ayurveda i.e; Satvavajaya chikitsa can be adopted in such situations. Jnana (knowledge of self), Vijnana (scientific reasoning), Dhairya (determination or patience), Smrithi (application of recollections or memory) and Samadhi (attaining a stable state of mind) are the steps of this management which are applicable in any psychological issues, including that resulting from COVID as well. Considering the severity of the symptoms, medical management can also be recommended. By adopting such measures mentioned in the Ayurvedic science, we can hope to provide relief to the affected and also to help them to physical and mental wellbeing.

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A comparative clinical study on the effect of Tagara (Valeriana wallichii DC.) and Jatamansi (Nardostachys jatamansi DC.) in the management of Anidra (primary insomnia)

Cited by 36 publications

References 7 publications

Natural product HTP screening for attenuation of cytokine-induced neutrophil chemo attractants (CINCs) and NO2− in LPS/IFNγ activated glioma cells

Natural product HTP screening for attenuation of cytokine-induced neutrophil chemo attractants (CINCs) and NO2− in LPS/IFNγ activated glioma cells

Serum Metabolic Profiling Reveals the Antidepressive Effects of the Total Iridoids of Valeriana jatamansi Jones on Chronic Unpredictable Mild Stress Mice

Psychological Issues In Covid 19 Outbreak - Ayurvedic Approach

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