A comparative cross-cultural study of the prevalence of late life depression in low and middle income countries

Guerra, Mariella; Prina, Matthew; Ferri, Cleusa P.; Acosta, Daisy; Gallardo, Sara; Huang, Yueqin; Jacob, K. S.; Jiménez‐Velázquez, Ivonne Z.; Rodriguez, Juan J. Llibre; Liu, Zhaorui; Salas, Aquiles; Sosa, Ana Luisa; Williams, Joseph; Uwakwe, Richard; Prince, Martin

doi:10.1016/j.jad.2015.09.004

Cited by 108 publications

(97 citation statements)

References 30 publications

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“…Unipolar depression occurs in 10%–38% of the elderly population 2,5. Overall, 35.3% of the cases of late-life depression may be regarded as mild, 51.9% as moderate, and 12.7% as severe 5.…”

Section: Epidemiology Of Mood Disorders In Late Lifementioning

confidence: 99%

Mood disorders in the elderly: prevalence, functional impact, and management challenges

Valiengo¹,

Stella

Forlenza³

2016

NDT

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Despite the lower prevalence of severe mood disorders in the elderly as compared to younger adults, late-life depression and bipolar disorder (BD) are more strongly associated with negative outcomes related to the presence of medical comorbidities, cognitive deficits, and increased suicide risk and overall mortality. The mechanisms that contribute to these associations are probably multifactorial, involving pathological factors related directly and indirectly to the disease itself, ranging from biological to psychosocial factors. Most of the accumulated knowledge on the nature of these associations derives from naturalistic and observational studies, and controlled data are still scarce. Nonetheless, there has clearly been a recent growth of the scientific interest on late-life BD and geriatric depression. In the present study, we review the most relevant studies on prevalence, clinical presentation, and cognitive/functional impact of mood disorders in elderly. Several clinical–epidemiological studies were dedicated to the study of the prevalence of mood disorders in old age in distinct settings; however, fewer studies investigated the underlying neurobiological findings and treatment specificities in late-life depression and BD. In the present study, we further discuss the implications of these findings on the management of mood disorders in older adults.

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Section: Epidemiology Of Mood Disorders In Late Lifementioning

confidence: 99%

Mood disorders in the elderly: prevalence, functional impact, and management challenges

Valiengo¹,

Stella

Forlenza³

2016

NDT

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“…Depression is an important public health problem, particularly among older adults in low-and middle-income countries (LMICs) (Guerra et al, 2016a) where a demographic transition, with an increasing number of older people, is rapidly occurring (Christensen et al, 2009). Not only does depression carry an immense mental health burden, but those with depressive disorders are also at a higher risk for various physical health co-morbidities such as hearing problems, arthritis and angina, among others Stubbs et al, 2017b;Vancampfort et al, 2016;Vancampfort et al, 2014;Vancampfort et al, 2015) and associated premature mortality (Corrrell et al, 2017;Walker et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

Handgrip strength and depression among 34,129 adults aged 50 years and older in six low- and middle-income countries

Ashdown-Franks

Stubbs

Koyanagi

et al. 2019

Journal of Affective Disorders

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HIGHLIGHTS Little is known about the relationship between handgrip strength and depression  Our data across 6 LMICs suggests weak handgrip strength is associated with depression.  Across all countries, weak handgrip strength was associated with a 1.45 (95%CI=1.12-1.88) times higher odds for depression.  Future research should seek to establish the predictive value of this inexpensive measure for clinical use.Abstract (250/250) Introduction: Handgrip strength is a simple and inexpensive marker of health and mortality risk. It presents an ideal risk-stratifying method for use in low and middle-income countries (LMICs). There are, however, no population-based studies investigating the associations between handgrip strength and depression in LMICs. We aimed to assess these associations among community-dwelling middleaged and older adults using nationally representative data from six LMICs. Method: Cross-sectional data on individuals aged ≥50 years from the World Health Organization's Study on Global Ageing and Adult Health were analyzed. Depression was based on the CompositeInternational Diagnostic Interview. Weak handgrip strength was defined as <30kg for men and <20 kg for women using the average value of two handgrip measurements of the dominant hand.Multivariable logistic regression analysis was conducted. Results:The sample included 34,129 individuals (62.4±16.0 years; 52.1% female). The prevalence of weak handgrip strength and depression were 47.4% and 6.2%, respectively. Individuals with weak handgrip strength had a higher prevalence of depression than those without this condition (8.8% vs.3.8%; p<0.001). Across all countries, after adjustment for potential confounders, weak handgrip strength was associated with a 1.45 (95%CI=1.12-1.88) times higher odds for depression, although some between-country differences were noted. Discussion:Weaker handgrip strength is associated with higher odds for depression in LMICs.Future research should seek to establish the predictive value of this inexpensive measure for clinical use. Furthermore, interventional studies should examine if muscular strength can be a target of resistance-training interventions to address depressive symptoms in low-resourced settings.

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“…In this cohort study of participants aged 50–63, we found the depression prevalence was 17.4%, which was comparable to the reported prevalence (ranging from 12.5% to 27.2%) in other studies (Copeland et al, , ; Volkert, Schulz, Harter, Wlodarczyk, & Andreas, ). These variations could be due to cultural (Börsch‐Supan, Hank, & Jürges, ; Guerra et al, ) and linguistic differences in response to the wording in the questions included in the depression assessment instrument (Castro‐Costa et al, ), the differences in socioeconomic status and working conditions, as well as in rates of nonparticipants. It is understandable that people with depression are less willing to participate in surveys; in our study, participants had lower depression prevalence (13.96%) as compared with nonparticipants (38.87%).…”

Section: Discussionmentioning

confidence: 99%

Reciprocal associations between job strain and depression: A 2‐year follow‐up study from the Survey of Health, Ageing and Retirement in Europe

Qiao

Zhang

et al. 2019

Brain and Behavior

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Background A growing number of people suffered from depression. This study examined the depression prevalence in workers across 10 European countries plus Israel and the reciprocal associations between job strain and depression. Methods The study population consisted of 7,879 workers aged 50–63 years at baseline (2004) from the Survey of Health, Ageing, and Retirement in Europe (SHARE). Job demands (physical or psychosocial) and job control variables were derived from the Job Content Questionnaire (JCQ). Two 4‐category job strains (physical and psychosocial) were obtained based on the cross‐tabulation of these dichotomized demands and control variables. There were 4,284 depression‐free, 3,259 high physical strain‐free and 3,195 high psychosocial strain‐free participants at baseline who were followed up for 2 years to detect incident depression, high physical job strain, or high psychosocial strain, respectively. The reciprocal associations between job strain and depression were analyzed by multivariate logistic regression and multivariate multilevel logistic regression adjusting for potential confounders. Results The prevalence of depression varied from the lowest 12.5% in Germany to the highest 27.2% in France. Compared to individuals with low strain, a significantly higher risk of depression were found in individuals with high physical strain (OR = 1.39) and high psychosocial strain (OR = 1.55), after adjusting for potential confounders. Depression at baseline was not significantly associated with subsequent high job strain. Similar results were observed from multilevel models that took into consideration of the potential country‐level influences. Conclusions The prevalence of depression varies across countries in Europe. Avoiding high job strain may be an effective preventive strategy to prevent depression epidemic.

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A comparative cross-cultural study of the prevalence of late life depression in low and middle income countries

Cited by 108 publications

References 30 publications

Mood disorders in the elderly: prevalence, functional impact, and management challenges

Mood disorders in the elderly: prevalence, functional impact, and management challenges

Handgrip strength and depression among 34,129 adults aged 50 years and older in six low- and middle-income countries

Reciprocal associations between job strain and depression: A 2‐year follow‐up study from the Survey of Health, Ageing and Retirement in Europe

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