A comparative evaluation of interleukin 1 beta and prostaglandin E2 with and without low-level laser therapy during En masse retraction

Jose, Jeffy Ann; Somaiah, Sanju; Muddaiah, Sunil; Shetty, Balakrishna; Reddy, Goutham; Roopa, S

doi:10.4103/ccd.ccd_859_17

Cited by 12 publications

(7 citation statements)

References 15 publications

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“…On the other hand, Ekizer et al did not observe significant changes in the levels of IL-1β between the laser and control groups. This cytokine is relevant in orthodontic movement, as it can enhance osteoclastic activity [ 32 ]. What may possibly contribute to this divergence of results in peri-implant inflammation is the difference of patients’ oral hygiene practices [ 33 ].…”

Section: Discussionmentioning

confidence: 99%

Effects of low-level laser therapy on the orthodontic mini-implants stability: a systematic review and meta-analysis

et al. 2021

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Objectives The aim of this systematic review and meta-analysis was to assess the effects of low-level laser therapy (LLLT) on the orthodontic mini-implants (OMI) stability. Materials and methods An unrestricted electronic database search in PubMed, Science Direct, Embase, Scopus, Web of Science, Cochrane Library, LILACS, Google Scholar, and ClinicalTrials.gov and a hand search were performed up to December 2020. Randomized clinical trials (RCTs) or non-randomized clinical trials (Non-RCTs) that assessed the effects of LLLT on the OMI stability were included. Data regarding the general information, LLLT characteristics, and outcomes were extracted. The authors performed risk of bias assessment with Cochrane Collaboration’s or ROBINS-I tool. Meta-analysis was also conducted. Results Five RCTs and one Non-RCT were included and 108 patients were evaluated. The LLLT characteristics presented different wavelength, power, energy density, irradiation time, and protocol duration. Five RCTs had a low risk of selection bias. Two RCTs had a low risk of performance and detection bias. All RCTs had a low risk of attrition bias, reporting bias and other bias. The Non-RCT presented a low risk of bias for all criteria, except for the bias in selection of participants. The meta-analysis revealed that LLLT significantly increased the OMI stability (p < 0.001, Cohen’s d = 0.67) and the highest clinical benefit was showed after 1 (p < 0.001, Cohen’s d = 0.75), 2 (p < 0.001, Cohen’s d = 1.21), and 3 (p < 0.001, Cohen’s d = 1.51) months of OMI placement. Conclusions LLLT shows positive effects on the OMI stability.

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Section: Discussionmentioning

confidence: 99%

Effects of low-level laser therapy on the orthodontic mini-implants stability: a systematic review and meta-analysis

et al. 2021

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“…However, during periodontal inflammation, the main mechanism of GCF formation becomes exudative, with an increase in its flow rate, and thus volume. [52] Cytokines produced by various cells are strong local mediators of inflammation. [53] GCF, an exudates, harnessed from the sulcus or periodontal pocket, has been regarded as a promising medium for the detection of periodontal disease activity.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of photodynamic therapy in pericoronitis

Schalch

Palmieri

Longo³

et al. 2019

Medicine

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Introduction:Pericoronitis is a common disease in the eruption phase of third molars, sometimes debilitating, with an impact on the quality of life. The most indicated treatment in the initial phase is the irrigation for cleanliness of the region. In order to reduce the chances of systemic dissemination of the infection and antibiotics use, it is mandatory to test effective treatments in the initial phase of pericoronitis avoiding the evolution of the infectious disease. Photodynamic therapy (PDT) is an interesting alternative because it is an effective antimicrobial treatment that is easy to perform and does not select bacterial resistance. The methylene blue (MB) used in PDT has been studied in an oral formulation, which optimizes the formation of monomers increasing its antimicrobial action.Objective:The aim of this study is to evaluate the effectiveness of PDT with MB in an astringent vehicle in pericoronitis on the initial phase in healthy patients through microbiological, clinical, and immune response. The impact of pericoronitis on oral health-related quality of life (OHRQoL) of these patients will also be evaluated.Method:In this randomized, controlled, double-blind clinical bioequivalence protocol, 64 healthy patients with pericoronitis will be evaluated. Patients will be randomized into the positive control group (G1) (n = 32): irrigation with sterile saline and PDT (conventional MB at 0.005% concentration and irradiation with low intensity laser λ = 660 nm, 9J per point and radiant exposure of 318 J/cm2), and the experimental group (G2) (n = 32): treatment identical to G1, however, MB will be delivered in a new formulation for oral use. Microbiological analysis will be performed by RT-PCR for the bacterium Tannerella forsythia. Gingival crevicular fluid and saliva will be collected to evaluate cytokines by Luminex assay (Luminex Corporation, Austin, TX). The pain (visual analogue scale), swelling and buccal opening (digital caliper), and OHRQoL will also be evaluated through the OHIP-14 questionnaire. The variables will be evaluated in T1 (baseline), T2 (immediately after PDT), and T3 (4th day after PDT). Registration: clinicaltrials.gov NCT 03576105. Registered in July 2018.

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“…The tooth movement acceleration was evaluated as the outcomes in 25 articles. [ 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 ] The pain reduction was assessed in 40 experiments. [ 18 20 , 21 23 , 24 28 , 37 38 39 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 ] Only five articles evaluated the impact of LLLT on root resorption.…”

Section: R Esultsmentioning

confidence: 99%

“…[ 22 ] Six experiments additionally collected gingival crevicular fluid (GCF) to analyze tooth movement-related substance, including IL-1β, TGF-β1, PGE 2 , MMP-9, OPG, OPN, and RANKL. [ 19 25 , 29 33 , 34 41 ]…”

Section: R Esultsmentioning

confidence: 99%

The Protocol of Low-level Laser Therapy in Orthodontic Practice

Sipiyaruk¹,

Chintavalakorn²,

Saengfai³

2022

Journal of International Society of Preventive and Community Dentistry

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A BSTRACT Low-level laser therapy (LLLT) has been widely investigated as an adjunct technique for orthodontic treatment due to photobiomodulation effect. LLLT appears to be supportive for an orthodontic practice in terms of tooth movement acceleration, pain relief, and root resorption management. The decrease in these adverse effects will enhance the compliance in orthodontic patients, which could positively impact treatment outcomes. However, there seemed to be inconsistency in the impact of LLLT as well as its laser and treatment parameters. This scoping review aimed to evaluate the impact of different irradiation parameters on tooth movement acceleration, pain relief, and root resorption as well as to construct a protocol of LLLT in orthodontic practice. The search was conducted across PubMed, Scopus, Web of Science, Embase, Google Scholar, and the reference lists of identified articles. The last search was conducted on October 10, 2021 to identify experiments in humans regarding the application of LLLT as noninvasive treatment in orthodontic practice published between 2010 and 2021. However, they were excluded if they were not clinical research, if they did not report the source of laser, or if they were not relevant to tooth movement, pain perception, and root resorption, or if they were not available in English or in full-text. Following the systematic search and selection process, 60 articles were included in this review. A majority of included articles were published in the past few years. The findings of this review supported the application of LLLT in orthodontic practice with purposes of tooth movement acceleration and pain reduction. The positive impact of LLLT on root resorption had not been clearly evident yet. As this review demonstrated heterogeneity of both laser and treatment parameters, further research should be required to ensure the effectiveness of its specific parameters in orthodontic practice.

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A comparative evaluation of interleukin 1 beta and prostaglandin E2 with and without low-level laser therapy during En masse retraction

Cited by 12 publications

References 15 publications

Effects of low-level laser therapy on the orthodontic mini-implants stability: a systematic review and meta-analysis

Effects of low-level laser therapy on the orthodontic mini-implants stability: a systematic review and meta-analysis

Evaluation of photodynamic therapy in pericoronitis

The Protocol of Low-level Laser Therapy in Orthodontic Practice

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