A Comparative Evaluation of the Antiproliferative Activity against HepG2 Liver Carcinoma Cells of Plant-Derived Silver Nanoparticles from Basil Extracts with Contrasting Anthocyanin Contents

Abbasi, Bilal Haider; Nazir, Munazza; Muhammad, Wali; Hashmi, Syed Salman; Abbasi, Rashda; Rahman, Lubna; Hano, Christophe

doi:10.3390/biom9080320

Cited by 40 publications

(23 citation statements)

References 42 publications

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“…Significantly higher TEAC values were noted for TS1–TS2 as compared to TS3–TS4. Many AgNPs solutions have been evaluated for their antioxidant capacities, commonly associated with the content of phenolic compounds from plant extracts [17,30,31]. Beech bark contains a range of biologically active components, such as tannins and polyphenols, indicating that the antioxidant activity of the AgNPs has been enhanced by these bio-components.…”

Section: Antioxidant Activity Of Agnpsmentioning

confidence: 99%

Investigation of In Vitro Antioxidant and Antibacterial Potential of Silver Nanoparticles Obtained by Biosynthesis Using Beech Bark Extract

et al. 2019

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Green synthesis is one of the rapid and best ways for silver nanoparticles (AgNP) synthesis. In the present study, synthesis and bioactivity of AgNPs has been demonstrated using water beech (Fagus sylvatica L.) bark extract. The physical and chemical factors such as time, metal ion solution, and pH, which play a vital role in the AgNPs synthesis, were assessed. The AgNPs were characterized by ultraviolet-visible (UV-Vis) spectrometry, Fourier transform infrared spectroscopy (FT-IR), and transmission electron microscopy (TEM). Antioxidant and antimicrobial activity of the obtained AgNPs was evaluated. AgNPs were characterized by color change pattern, and the broad peak obtained at 420–475 nm with UV-Vis confirmed the synthesis of AgNPs. FT-IR results confirmed that phenols and proteins of beech bark extract are mainly responsible for capping and stabilization of synthesized AgNPs. TEM micrographs showed spherical or rarely polygonal and triangular particles with an average size of 32 nm at pH = 9, and 62 nm at pH = 4. Furthermore, synthesized AgNPs were found to exhibit antioxidant activity and have antibacterial effect against Staphylococcus aureus, methicillin-resistant Staphylococcus aureus (MRSA), Escherichia coli, and Pseudomonas aeruginosa. These results indicate that bark extract of F. sylvatica L. is suitable for synthesizing stable AgNPs, which act as an excellent antimicrobial agent.

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Section: Antioxidant Activity Of Agnpsmentioning

confidence: 99%

Investigation of In Vitro Antioxidant and Antibacterial Potential of Silver Nanoparticles Obtained by Biosynthesis Using Beech Bark Extract

et al. 2019

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“…Approximately 90% of liver cancers are recognized as hepatocellular carcinomas (HCCs) and 10% are cholangiocarcinomas (CCAs) [ 200 ]. Due to the asymptomatic feature of this disease, a diagnosis is made at an advanced stage and therefore therapeutic approaches remain ineffective [ 201 ]. A deeper exploration of the biology of HCC and CCA, regarding the development of potential therapies, is desperately needed.…”

Section: Anticancer Activities Of Rutinmentioning

confidence: 99%

Targeting Multiple Signaling Pathways in Cancer: The Rutin Therapeutic Approach

Nouri

Fakhri

Nouri

et al. 2020

Cancers

139

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Multiple dysregulated signaling pathways are implicated in the pathogenesis of cancer. The conventional therapies used in cancer prevention/treatment suffer from low efficacy, considerable toxicity, and high cost. Hence, the discovery and development of novel multi-targeted agents to attenuate the dysregulated signaling in cancer is of great importance. In recent decades, phytochemicals from dietary and medicinal plants have been successfully introduced as alternative anticancer agents due to their ability to modulate numerous oncogenic and oncosuppressive signaling pathways. Rutin (also known as rutoside, quercetin-3-O-rutinoside and sophorin) is an active plant-derived flavonoid that is widely distributed in various vegetables, fruits, and medicinal plants, including asparagus, buckwheat, apricots, apples, cherries, grapes, grapefruit, plums, oranges, and tea. Rutin has been shown to target various inflammatory, apoptotic, autophagic, and angiogenic signaling mediators, including nuclear factor-κB, tumor necrosis factor-α, interleukins, light chain 3/Beclin, B cell lymphoma 2 (Bcl-2), Bcl-2 associated X protein, caspases, and vascular endothelial growth factor. A comprehensive and critical analysis of the anticancer potential of rutin and associated molecular targets amongst various cancer types has not been performed previously. Accordingly, the purpose of this review is to present an up-to-date and critical evaluation of multiple cellular and molecular mechanisms through which the anticancer effects of rutin are known to be exerted. The current challenges and limitations as well as future directions of research are also discussed.

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“…Currently, nanotechnology has revolutionized the biomedical field by offering advantages in both diagnostics and therapeutic applications. [ 28 ] The interaction of nanomaterials and microorganisms is considered as a potential treatment method because the nanomaterials owe unique physicochemical properties. [ 29 ] The biological system builds a strong bridge with the nanoscience field nowadays, combining both phenomena of nanobiotechnology and nanomedicine to diagnose, prevent, and treat diseases.…”

Section: Nanotechnology Role In Viral Infectionsmentioning

confidence: 99%

Antiviral Activity of Nanomaterials against Coronaviruses

Muhammad

Zhai

Gao

2020

Macromolecular Bioscience

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NPs may target a desired part of the body, whereas conventional drug formulations typically distribute throughout the entire body. In the case of nanovaccines, they can be designed to better target lymphatic organs and immune cells to promote better immune responses than the conventional vaccines. Sometimes the localized infection is difficult to be reached by the conventional vaccines, but can be cured by the nanovaccines with specific cells or organs-targeting molecules. In some situations, the nano-based systems are used to enhance the solubility of hydrophobic compounds. These systems not only preserve the reliability of antigens toward degradation but also stabilize a large number of therapeutic agents such as peptides, proteins, and nucleic acids. [9] Viral infections can pose challenges for global public health because of their problematic widespreading distribution and their potential to develop through genetic mutation. [10] Viral infections cause a high number of deaths and a disturbing health care system in a few decades. [10] Recently, a new strain of coronavirus (severe acute respiratory syndrome coronavirus-2, SARS-CoV-2) has led to a pandemic situation that killed 597 583 (WHO, July 19, 2020) with millions of cases all over the world. The CoV belongs to the Coronaviridae family of Nidovirales order, [11-13] whose genomes usually range from 26 to 32 kb. [14] These viruses are called Coronaviruses (CoVes) because of the protruding spike proteins on their envelope that give the virions of crown-shaped. [15,16] Six CoVes species are responsible for the infection of humans, in which four of them (229E, OC43, NL63, and HKU1) are predominant and cause symptoms of a common cold in immunocompetent individuals. [17] While the other two strains are known as severe acute respiratory syndrome coronavirus (SARS-CoV) and Middle East respiratory syndrome coronavirus (MERS-CoV), which cause fatal diseases. [18,19] The acute respiratory cases appeared in early 2003 in China were caused by SARS-CoV, [20,21] while the MERS-CoV was the responsible pathogen for the Middle East outbreaks of severe respiratory disease in 2012. [22,23] The novel strain (SARS-CoV-2) caused pneumonia that seriously contributed to lung injuries. Identified scanning electron microscopy (SEM) image of SARS-CoV-2 is shown in Figure 1. The disease caused by this serious strain is termed as coronavirus diseases 2019 (COVID-19). To reduce infectious disease transmission, suitable methods are required based on the nature of the disease and mode of transmission. [24] For instance, vaccination is required for some One of the challenges facing by world nowadays is the generation of new pathogens that cause public health issues. Coronavirus (CoV) is one of the severe pathogens that possess the RNA (ribonucleic acid) envelop, and extensively infect humans, birds, and other mammals. The novel strain "SARS-CoV-2" (severe acute respiratory syndrome coronavirus-2) causes deadly infection all over the world and presents a pandemic situation nowadays. The SARS...

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A Comparative Evaluation of the Antiproliferative Activity against HepG2 Liver Carcinoma Cells of Plant-Derived Silver Nanoparticles from Basil Extracts with Contrasting Anthocyanin Contents

Cited by 40 publications

References 42 publications

Investigation of In Vitro Antioxidant and Antibacterial Potential of Silver Nanoparticles Obtained by Biosynthesis Using Beech Bark Extract

Investigation of In Vitro Antioxidant and Antibacterial Potential of Silver Nanoparticles Obtained by Biosynthesis Using Beech Bark Extract

Targeting Multiple Signaling Pathways in Cancer: The Rutin Therapeutic Approach

Antiviral Activity of Nanomaterials against Coronaviruses

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