A comparative examination of morphine and fentanyl: unravelling the differential impacts on breathing and airway stability
Nicholas J. Burgraff,
Nathan A. Baertsch,
Jan‐Marino Ramirez
Abstract:This study provides an in‐depth analysis of the distinct consequences of the opioid drugs morphine and fentanyl during opioid‐induced respiratory depression (OIRD). We explored the physiological implications of both drugs on ventilation and airway patency in anaesthetized mice. Our results revealed a similar reduction in respiratory frequency with equivalent scaled dosages of fentanyl and morphine, though the onset of suppression was more rapid with fentanyl. Additionally, fentanyl resulted in transient airflo… Show more
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