A Comparative Interaction of Epinephrine with Enflurane, Isoflurane, and Halothane in Man

Johnston, Richard H.; Eger, Edmond I.; Wilson, Charles B.

doi:10.1213/00000539-197609000-00021

Cited by 252 publications

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“…4 and might therefore be considered as potentially better agents in drawover anaesthesia. Both have been used as sole agents in this way, without the addition of trichloroethylene.7B Consideration of the physical properties of the volatile anaesthetics suggests that enflurane and isoflurane would be characterised by a more rapid induction and r e c~v e r y .~ However, previous evaluation of these aspects has yielded contradictory result^.^^-'^ This study set out not to clarify these purely theoretical aspects but to assess the performance of enflurane and isoflurane in the Triservice apparatus from the user's point of view.…”

Section: Discussionmentioning

confidence: 99%

The Triservice anaesthetic apparatus

Kocan

1987

Anaesthesia

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Summary Sixty male patients undergoing limb surgery were anaesthetised using a drawover technique with the Triservice apparatus. They were randomly allocated to receive trichloroethylene and one of three other volatile agents (halothane, enflurane or isoflurane) after thiopentone induction. Signs of inadequate anaesthesia were noted. The incidence of such signs was not significantly different in the three groups. Similarly, no qualitative difference could be demonstrated in the immediate recovery, but the recovery time was significantly shorter with enflurane.

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Section: Discussionmentioning

confidence: 99%

The Triservice anaesthetic apparatus

Kocan

1987

Anaesthesia

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“…For comparison Johnston reported an arrhythmogenic epinephrine dose of 2.1 p,g.kg -1 during halothane anaesthesia in human adults. 17 The pig may indeed be a better model than the dog for comparison to humans. 18 This study substantiates the clinical observation that there is an age-related difference in the susceptibility to epinephrine induced arrhythmias during halothane anaesthesia.…”

Section: Discussionmentioning

confidence: 99%

Effect of age on epinephrine-induced arrhythmias during halothane anaesthesia in pigs

et al. 1984

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“…Halothane also sensitizes the myocardium to circulating catecholamines, producing ventricular arrhythmias. The dosage of submucosally administered epinephrine that produced ventricular arrhythmias in 50% of patients was 2.1, 6.7 and 10.9 µg/kg for halothane, isoflurane and ethrane, respectively (40). The threshold dose of epinephrine causing ventricular arrhythmias during sevoflurane anaesthesia is 5 µg/kg (41).…”

Section: Adjuvant Therapy For the Intubated Patientmentioning

confidence: 97%

“…The threshold dose of epinephrine causing ventricular arrhythmias during sevoflurane anaesthesia is 5 µg/kg (41). Children are able to tolerate larger doses of epinephrine under halothane anesthesia compared with adults (10 µg/kg versus 7.8 µg/kg) (40). Administration of anaesthetic agents is not a common procedure in the intensive care unit; however, Sullivan and Robbins (42) described a delivery system that is easily attached to an intensive care unit ventilator enabling delivery of isoflurane.…”

Section: Adjuvant Therapy For the Intubated Patientmentioning

confidence: 99%

Ventilatory Care in Status Asthmaticus

Smyth¹

1998

Canadian Respiratory Journal

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Asthma continues to pose a significant medical problem in terms of both morbidity and mortality. A number of patients with a severe exacerbation of asthma fail medical therapy and require urgent intubation and mechanical ventilation. New modalities of ventilatory support, including noninvasive ventilation, have been shown to provide effective ventilation even in the presence of severe bronchoconstriction. An intrinsically high level of auto positive end-expiratory pressure in these patients requires a precise balance between respiratory frequency, tidal volume and inspiratory flow rates. Pressure support ventilation reduces the risk of barotrauma and lowers the work of breathing in these patients. Adjuvant therapy with inhaled anesthetics and bronchoalveolar lavage may also be indicated in patients requiring high pressures to achieve adequate ventilation.

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A Comparative Interaction of Epinephrine with Enflurane, Isoflurane, and Halothane in Man

Cited by 252 publications

References 0 publications

The Triservice anaesthetic apparatus

The Triservice anaesthetic apparatus

Effect of age on epinephrine-induced arrhythmias during halothane anaesthesia in pigs

Ventilatory Care in Status Asthmaticus

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