A Comparative Perspective on Brain Regeneration in Amphibians and Teleost Fish

Lust, Katharina; Tanaka, Elly M.

doi:10.1002/dneu.22665

Cited by 37 publications

(33 citation statements)

References 73 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Adult salamanders can regenerate various damaged neural tissues, including retinae, brain regions and the spinal cord, both in terms of structure and function Lust and Tanaka, 2019). Damage to the central nervous system (CNS) usually affects both neuronal and non-neuronal cell types and, depending on the extent of damage, may lead to behavioural abnormalities.…”

Section: Regeneration Of Neural Tissues: Regrowing Integrating and Rmentioning

confidence: 99%

Model systems for regeneration: salamanders

2019

View full text Add to dashboard Cite

Salamanders have been hailed as champions of regeneration, exhibiting a remarkable ability to regrow tissues, organs and even whole body parts, e.g. their limbs. As such, salamanders have provided key insights into the mechanisms by which cells, tissues and organs sense and regenerate missing or damaged parts. In this Primer, we cover the evolutionary context in which salamanders emerged. We outline the varieties of mechanisms deployed during salamander regeneration, and discuss how these mechanisms are currently being explored and how they have advanced our understanding of animal regeneration. We also present arguments about why it is important to study closely related species in regeneration research.

show abstract

Section: Regeneration Of Neural Tissues: Regrowing Integrating and Rmentioning

confidence: 99%

Model systems for regeneration: salamanders

2019

View full text Add to dashboard Cite

show abstract

“…The pallium and subpallium comprise the left and right hemispheres. Axolotl pallium is interesting due to its capacity to regenerate after damage 4 , a trait probably present in other salamanders 7 . Because our MRI did not allow enough contrast to differentiate structures such as the dorsal pallium, lateral pallium, medial pallium and striatum and septum, we decided to further segment these regions manually using visual inspection from drawings in previous publications (Supplementary Table 1).…”

Section: Telencephalonmentioning

confidence: 99%

“…Although this capacity has placed axolotl as an animal model for neural regeneration studies, a thorough comprehension of the nervous system of this taxon remains obscure. In this context, and although some axolotl brain structures have been well described by several authors [5][6][7] , only an histological atlas of the compete brain of this species is available (https://msu.edu/course/zol/402/atlas/). In general terms, the juvenile-adult brain of axolotl (and other amphibians) is composed by regions similar to those of other vertebrates: olfactory bulb, telencephalon, diencephalon, mesencephalon, and rhombencephalon.…”

Section: Introductionmentioning

confidence: 99%

MRI- and histologically derived neuroanatomical atlas of theAmbystoma mexicanum(axolotl)

Lazcano

Cisneros-Mejorado

Concha

et al. 2020

Preprint

View full text Add to dashboard Cite

Amphibians are an important vertebrate model system to understand anatomy, genetics and physiology. Importantly, the brain and spinal cord of adult urodels (salamanders) have an incredible regeneration capacity, contrary to anurans (frogs) and the rest of adult vertebrates. Among these amphibians, the axolotl (Ambystoma mexicanum) has gained most attention because of the surge in the understanding of CNS regeneration and the recent sequencing of its whole genome. However, a complete comprehension of the brain anatomy is not available. In the present study we created a magnetic resonance imaging atlas of the in vivo neuroanatomy of the juvenile axolotl brain. This is the first MRI atlas for this species and includes 3 levels: 1) 80 regions of interest (ROIs); 2) a division of the brain according to the embryological origin of the neural tube, and 3) left and right hemispheres. Additionally, we localized the myelin rich regions of the juvenile brain. The atlas, the template that the atlas was derived from, and a masking file, can be found on Zenodo at DOI: 10.5281/zenodo.4311937. This MRI brain atlas aims to be an important tool for future research of the axolotl brain and that of other amphibians.

show abstract

“…Salamanders exhibit the ability to compensate for cell losses in various regions of the brain and spinal cord, even in the mature state [ 84 ]. The brain regeneration in Urodela becomes possible due to the neural stem cells, the so-called ependymoglial cells, present in the ventricular regions [ 85 , 86 , 87 , 88 ].…”

Section: Specifics Of Eye and Brain Tissues And Their Regenerationmentioning

confidence: 99%

Study of Natural Longlife Juvenility and Tissue Regeneration in Caudate Amphibians and Potential Application of Resulting Data in Biomedicine

Grigoryan

2021

JDB

View full text Add to dashboard Cite

The review considers the molecular, cellular, organismal, and ontogenetic properties of Urodela that exhibit the highest regenerative abilities among tetrapods. The genome specifics and the expression of genes associated with cell plasticity are analyzed. The simplification of tissue structure is shown using the examples of the sensory retina and brain in mature Urodela. Cells of these and some other tissues are ready to initiate proliferation and manifest the plasticity of their phenotype as well as the correct integration into the pre-existing or de novo forming tissue structure. Without excluding other factors that determine regeneration, the pedomorphosis and juvenile properties, identified on different levels of Urodele amphibians, are assumed to be the main explanation for their high regenerative abilities. These properties, being fundamental for tissue regeneration, have been lost by amniotes. Experiments aimed at mammalian cell rejuvenation currently use various approaches. They include, in particular, methods that use secretomes from regenerating tissues of caudate amphibians and fish for inducing regenerative responses of cells. Such an approach, along with those developed on the basis of knowledge about the molecular and genetic nature and age dependence of regeneration, may become one more step in the development of regenerative medicine

show abstract

A Comparative Perspective on Brain Regeneration in Amphibians and Teleost Fish

Cited by 37 publications

References 73 publications

Model systems for regeneration: salamanders

Model systems for regeneration: salamanders

MRI- and histologically derived neuroanatomical atlas of theAmbystoma mexicanum(axolotl)

Study of Natural Longlife Juvenility and Tissue Regeneration in Caudate Amphibians and Potential Application of Resulting Data in Biomedicine

Contact Info

Product

Resources

About